Does the prognosis of colorectal mucinous carcinoma depend upon the primary tumour site? Results from two independent databases

ObjectivesWe aimed (1) to assess the nutritional status (NS) using different methods, according to the primary tumour site and (2) to evaluate the performance of these methods in patients with incurable cancer from a reference centre in Brazil.MethodsCross-sectional analysis of data from patients admitted to the palliative care unit of a reference cancer centre in Brazil, between July 2016 and March 2020. The primary tumour site was the independent variable and the NS using different methods were the dependent variables. Logistic regressions were performed.ResultsA total of 2,144 patients were included in the study. The most common primary tumour site was the upper gastrointestinal (GI) tract (18.0%), followed by gynaecological (17.6%) and head and neck (HN) (13.5%). Our results showed that patients with tumours of the upper GI tract followed by HN presented significantly higher risk of worse NS. In contrast, breast tumours, bone and connective tissues and melanoma presented inverse association. The gynaecological cancer was variably associated with nutritional impairment, according to the assessment method.ConclusionsPatients with incurable cancer present high prevalence of NS impairment, depending on the tumour site, shown to be elevated in patients with tumour in the upper GI tract.

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Survival outcome differences based on treatments used and knowledge of the primary tumour site for patients with cancer of unknown and known primary in Ontario

Current Oncology ◽

10.3747/co.25.4003 ◽

2018 ◽

Vol 25 (5) ◽

Cited By ~ 1

Author(s):

C. S. Kim ◽

M. B. Hannouf ◽

S. Sarma ◽

G. B. Rodrigues ◽

P. K. Rogan ◽

...

Keyword(s):

Median Survival ◽

Cox Regression ◽

Metastatic Cancer ◽

Primary Tumour ◽

Primary Site ◽

Unknown Primary ◽

Survival Outcomes ◽

Tumour Site ◽

Ontario Health Insurance Plan ◽

Primary Tumour Site

IntroductionPatients with cancer of unknown primary (cup) have pathologically confirmed metastatic tumours with unidentifiable primary tumours. Currently, very little is known about the relationship between the treatment of patients with cup and their survival outcomes. Thus, we compared oncologic treatment and survival outcomes for patients in Ontario with cup against those for a cohort of patients with metastatic cancer of known primary site.Methods Using the Ontario Cancer Registry and the Same-Day Surgery and Discharge Abstract databases maintained by the Canadian Institute for Health Information, we identified all Ontario patients diagnosed with metastatic cancer between 1 January 2000 and 31 December 2005. Ontario Health Insurance Plan treatment records were linked to identify codes for surgery, chemotherapy, or therapeutic radiation related to oncology. Multivariable Cox regression models were constructed, adjusting for histology, age, sex, and comorbidities.Results In 45,347 patients (96.3%), the primary tumour site was identifiable, and in 1743 patients (3.7%), cup was diagnosed. Among the main tumour sites, cup ranked as the 6th largest. The mean Charlson score was significantly higher (p < 0.0001) in patients with cup (1.88) than in those with a known primary (1.42). Overall median survival was 1.9 months for patients with cup compared with 11.9 months for all patients with a known-primary cancer. Receipt of treatment was more likely for patients with a known primary site (n = 35,012, 77.2%) than for those with cup (n = 891, 51.1%). Among patients with a known primary site, median survival was significantly higher for treated than for untreated patients (19.0 months vs. 2.2 months, p < 0.0001). Among patients with cup, median survival was also higher for treated than for untreated patients (3.6 months vs. 1.1 months, p < 0.0001).Conclusions In Ontario, patients with cup experience significantly lower survival than do patients with metastatic cancer of a known primary site. Treatment is associated with significantly increased survival both for patients with cup and for those with metastatic cancer of a known primary site.

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Malignant Ascites Of Unknown Primary Tumour Site: A Clinical Dilemma

The Internet Journal of Surgery ◽

10.5580/1b7d ◽

2007 ◽

Vol 11 (1) ◽

Keyword(s):

Primary Tumour ◽

Malignant Ascites ◽

Unknown Primary ◽

Tumour Site ◽

Unknown Primary Tumour ◽

Clinical Dilemma ◽

Primary Tumour Site

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Our experience and outcomes following indwelling pleural catheter (IPC) insertion at the University Hospital Coventry and Warwickshire (UHCW) and the effect of primary tumour site on outcomes

10.1183/13993003.congress-2020.2922 ◽

2020 ◽

Author(s):

Viren Ahluwalia ◽

Vishal Nathwani ◽

Joseph Glover

Keyword(s):

Primary Tumour ◽

University Hospital ◽

Tumour Site ◽

Indwelling Pleural Catheter ◽

Pleural Catheter ◽

The University ◽

Primary Tumour Site

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Prognostic role of the primary tumour site in patients with operable small intestine and gastrointestinal stromal tumours: a large population-based analysis

Oncotarget ◽

10.18632/oncotarget.23692 ◽

2017 ◽

Vol 9 (8) ◽

pp. 8147-8154 ◽

Cited By ~ 2

Author(s):

Hua Ye ◽

Hua Xin ◽

Qi Zheng ◽

Qijun Shen ◽

Wenyu Dai ◽

...

Keyword(s):

Small Intestine ◽

Primary Tumour ◽

Large Population ◽

Population Based ◽

Prognostic Role ◽

Gastrointestinal Stromal Tumours ◽

Tumour Site ◽

Primary Tumour Site

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Novel patient risk factors and validation of a difficulty scoring system in laparoscopic repeat hepatectomy

Scientific Reports ◽

10.1038/s41598-019-54099-w ◽

2019 ◽

Vol 9 (1) ◽

Cited By ~ 2

Author(s):

Yukiyasu Okamura ◽

Yusuke Yamamoto ◽

Teiichi Sugiura ◽

Takaaki Ito ◽

Ryo Ashida ◽

...

Keyword(s):

Risk Factors ◽

Blood Loss ◽

Scoring System ◽

Risk Group ◽

Primary Tumour ◽

Repeat Hepatectomy ◽

Tumour Site ◽

Blood Loss Volume ◽

Lateral Sectionectomy ◽

Primary Tumour Site

AbstractThe indications for laparoscopic liver resection have expanded; however, the safety and benefits of laparoscopic repeat hepatectomy (LRH) remain unclear. We retrospectively reviewed data from 137 patients who underwent partial hepatectomy or left lateral sectionectomy without thoracotomy. We compared patients’ clinical factors using a difficulty scoring system for LRH. We defined factors associated with blood loss volumes in the 75th percentile or above as risk factors for bleeding in open repeat hepatectomy, and determined whether these factors were useful for LRH risk assessment. Open repeat hepatectomy and LRH was performed in 96 and 41 patients, respectively. Four of 41 (9.8%) patients undergoing LRH were converted to laparotomy. Blood loss volume was significantly greater in the intermediate-risk group than in the low-risk group (P = 0.046). Multivariate analysis revealed that the presence of tumours located adjacent and caudal or dorsal to the primary tumour site was an independent risk factor for bleeding in LRH (odds ratio 3.21, 95% confidence interval 1.16–8.88, P = 0.024). Our study validated the usefulness of a difficulty scoring system, identified patient factors that predicted the difficulty of LRH, and presented a novel difficulty scoring system for LRH based on an existing difficulty scoring system.

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Thyroid Gland as a Target of Secondary Malignancies - an Autopsy Study and Review Data

Folia Medica ◽

10.2478/folmed-2018-0077 ◽

2019 ◽

Vol 61 (2) ◽

pp. 277-288 ◽

Cited By ~ 1

Author(s):

Antigony Mistelou ◽

Stamatis S. Papadatos ◽

Chrysavgi Kousi ◽

Evangeli Lampri ◽

Michael Mitsis ◽

...

Keyword(s):

Thyroid Gland ◽

Primary Tumour ◽

Secondary Malignancies ◽

Multinodular Goitre ◽

Malignant Tumours ◽

Tumour Site ◽

Autopsy Study ◽

Diffuse Infiltration ◽

North Western ◽

Primary Tumour Site

Abstract Aim: Secondary malignancies of the thyroid gland are rarely diagnosed but their incidence at autopsy is not uncommon. Materials and methods: To investigate the clinicopathological features of patients with metastatic tumours of the thyroid gland, we reviewed autopsy records and pathological features of 36 cases with thyroidal secondary tumours from 266 cases of malignant neoplasias (excluding cases of primary thyroid cancer), over a 16-year period. Results: There were 19 men and 17 women in the study, ranging in age from 37 to 95 years (mean 70.4 years). The incidence of metastasis in thyroid gland was 0.9% in all autopsy cases, and 13.53% of the malignant tumours. The majority were carcinomas of epithelial origin. The lung was the most common primary tumour site (33.3%), followed by the breast (8.33%) and the kidney (8.33%). The most common non-epithelial malignancy was lymphoma, followed by leukaemia (total of both 25%). As for the microscopic morphological observations, diffuse infiltration pattern of tumour cells was noted in 63.89% of the cases, the formation of nodules in 33.33% of the cases and contiguous invasion in 2.79% of the cases. There were 35.71% cases of metastases associated with multinodular goitre and 28.57% cases associated with papillary microcarcinoma. Conclusion: Our study indicates that thyroid secondary malignancies are not infrequent and may constitute a diagnostic problem. Lung cancer is the most common neoplasm that metastasizes to the thyroid gland in north-western Greek population.

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