Malignant Ascites Of Unknown Primary Tumour Site: A Clinical Dilemma

10.5580/1b7d ◽  
2007 ◽  
Vol 11 (1) ◽  
Keyword(s):  
Primary Tumour ◽  
Malignant Ascites ◽  
Unknown Primary ◽  
Tumour Site ◽  
Unknown Primary Tumour ◽  
Clinical Dilemma ◽  
Primary Tumour Site

scholarly journals Survival outcome differences based on treatments used and knowledge of the primary tumour site for patients with cancer of unknown and known primary in Ontario

2018 ◽  
Vol 25 (5) ◽  
Author(s):  
C. S. Kim ◽  
M. B. Hannouf ◽  
S. Sarma ◽  
G. B. Rodrigues ◽  
P. K. Rogan ◽  
...  
Keyword(s):  
Median Survival ◽  
Cox Regression ◽  
Metastatic Cancer ◽  
Primary Tumour ◽  
Primary Site ◽  
Unknown Primary ◽  
Survival Outcomes ◽  
Tumour Site ◽  
Ontario Health Insurance Plan ◽  
Primary Tumour Site

IntroductionPatients with cancer of unknown primary (cup) have pathologically confirmed metastatic tumours with unidentifiable primary tumours. Currently, very little is known about the relationship between the treatment of patients with cup and their survival outcomes. Thus, we compared oncologic treatment and survival outcomes for patients in Ontario with cup against those for a cohort of patients with metastatic cancer of known primary site.Methods Using the Ontario Cancer Registry and the Same-Day Surgery and Discharge Abstract databases maintained by the Canadian Institute for Health Information, we identified all Ontario patients diagnosed with metastatic cancer between 1 January 2000 and 31 December 2005. Ontario Health Insurance Plan treatment records were linked to identify codes for surgery, chemotherapy, or therapeutic radiation related to oncology. Multivariable Cox regression models were constructed, adjusting for histology, age, sex, and comorbidities.Results In 45,347 patients (96.3%), the primary tumour site was identifiable, and in 1743 patients (3.7%), cup was diagnosed. Among the main tumour sites, cup ranked as the 6th largest. The mean Charlson score was significantly higher (p < 0.0001) in patients with cup (1.88) than in those with a known primary (1.42). Overall median survival was 1.9 months for patients with cup compared with 11.9 months for all patients with a known-primary cancer. Receipt of treatment was more likely for patients with a known primary site (n = 35,012, 77.2%) than for those with cup (n = 891, 51.1%). Among patients with a known primary site, median survival was significantly higher for treated than for untreated patients (19.0 months vs. 2.2 months, p < 0.0001). Among patients with cup, median survival was also higher for treated than for untreated patients (3.6 months vs. 1.1 months, p < 0.0001).Conclusions In Ontario, patients with cup experience significantly lower survival than do patients with metastatic cancer of a known primary site. Treatment is associated with significantly increased survival both for patients with cup and for those with metastatic cancer of a known primary site.

Identification of the occult tumor in cancer of unknown primary (CUP): A priority based on histology.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. 1605-1605 ◽  
Author(s):  
Chong Sung Kim ◽  
Malek Bassam Hannouf ◽  
Muriel Brackstone ◽  
Eric Winquist ◽  
Gregory S Zaric
Keyword(s):  
Cancer Registry ◽  
Primary Tumour ◽  
Cancer Of Unknown Primary ◽  
Rank Test ◽  
Unknown Primary ◽  
Metastatic Tumour ◽  
Tumour Site ◽  
Log Rank Test ◽  
Ontario Cancer Registry ◽  
Primary Tumour Site

1605 Background: The poor prognosis of cancer of unknown primary (CUP) patients is likely to improve with knowledge of the primary site. CUP patients form a diverse clinicopathological group; however, there remains doubt as CUP may indeed represent a unique clinical classification. Methods: We used the Ontario Cancer Registry to identify all patients diagnosed with cancer from January 2000 to December 2005. We linked these patients with the Canadian Institute of Health Information Same Day Surgery and Discharge Abstract Database to identify those who were initially diagnosed with a metastatic tumour. Information on clinical and pathological characteristics including age, gender, primary tumour site, histology, and second primary were available from the Ontario Cancer Registry. We stratified results according to primary tumour site and histology. Five-year survival data were available for all patients and were obtained from the Ontario Cancer Registry. Results: Of 52,619 patients diagnosed with metastatic tumour at the time of their initial cancer diagnosis, 4,866 (9.2%) patients were diagnosed with CUP and 47,753 (90.8%) patients were diagnosed with metastasis of known primary. The 5-year Kaplan-Meier estimate of CUP overall survival (OS) differed significantly with patients diagnosed with metastasis of known primary (median OS= 1.0 versus 10.4 months, respectively, log–rank test p<0.0001). In subgroup analyses, the 5-year OS of CUP patients with adenocarcinoma (n=1,389, median OS=1.83) was significantly worse when compared to metastatic adenocarcinoma of known primary (log-rank test p<0.0001). An identical result was obtained with CUP patients of undifferentiated histology (n=3,230). The 5-year OS of CUP patients with squamous cell carcinoma (n=247, median OS=18.5) did not differ significantly with those of other squamous cell carcinoma groups of known primary (log-rank test p>0.56). Conclusions: Although CUP patients as a whole have a poor prognosis compared to other metastatic patients of known primary, distinct subsets of CUP patients have similar prognosis. These data suggest that an intensive diagnostic approach for identification of the primary is not justified for all CUP patients.

The emerging role of trans-oral robotic surgery for the detection of the primary tumour site in patients with head-neck unknown primary cancers: A meta-analysis

2019 ◽  
Vol 46 (5) ◽  
pp. 663-671 ◽  
Author(s):  
Giuseppe Meccariello ◽  
Giovanni Cammaroto ◽  
Enyinnaya Ofo ◽  
Sebastiano Calpona ◽  
Elisabetta Parisi ◽  
...  
Keyword(s):  
Robotic Surgery ◽  
Meta Analysis ◽  
Primary Tumour ◽  
Unknown Primary ◽  
Tumour Site ◽  
Head Neck ◽  
Primary Tumour Site

Nutritional status and primary tumour site in incurable cancer

2021 ◽  
pp. bmjspcare-2021-003321
Author(s):  
Livia Costa De Oliveira ◽  
Emanuelly Varea Maria Wiegert ◽  
Lara Azevedo dos Santos ◽  
Larissa Calixto-Lima
Keyword(s):  
Nutritional Status ◽  
Primary Tumour ◽  
Inverse Association ◽  
Gi Tract ◽  
Tumour Site ◽  
Incurable Cancer ◽  
Cross Sectional ◽  
Upper Gi ◽  
Primary Tumour Site ◽  
Upper Gi Tract

ObjectivesWe aimed (1) to assess the nutritional status (NS) using different methods, according to the primary tumour site and (2) to evaluate the performance of these methods in patients with incurable cancer from a reference centre in Brazil.MethodsCross-sectional analysis of data from patients admitted to the palliative care unit of a reference cancer centre in Brazil, between July 2016 and March 2020. The primary tumour site was the independent variable and the NS using different methods were the dependent variables. Logistic regressions were performed.ResultsA total of 2,144 patients were included in the study. The most common primary tumour site was the upper gastrointestinal (GI) tract (18.0%), followed by gynaecological (17.6%) and head and neck (HN) (13.5%). Our results showed that patients with tumours of the upper GI tract followed by HN presented significantly higher risk of worse NS. In contrast, breast tumours, bone and connective tissues and melanoma presented inverse association. The gynaecological cancer was variably associated with nutritional impairment, according to the assessment method.ConclusionsPatients with incurable cancer present high prevalence of NS impairment, depending on the tumour site, shown to be elevated in patients with tumour in the upper GI tract.

Does the prognosis of colorectal mucinous carcinoma depend upon the primary tumour site? Results from two independent databases

2013 ◽  
pp. n/a-n/a ◽  
Author(s):  
Peng Gao ◽  
Yong-xi Song ◽  
Ying-ying Xu ◽  
Zhe Sun ◽  
Jing-xu Sun ◽  
...  
Keyword(s):  
Primary Tumour ◽  
Mucinous Carcinoma ◽  
Tumour Site ◽  
Primary Tumour Site

The Unknown Primary Tumour Presenting as Metastatic Spinal Cord Compression

2013 ◽  
Vol 13 (9) ◽  
pp. S129
Author(s):  
Nasir A. Quraishi ◽  
Sakthivel Rajan Rajaram Manoharan ◽  
Georgios Arealis ◽  
Hossein Mehdian ◽  
Bronek M. Boszczyk
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Compression ◽  
Primary Tumour ◽  
Cord Compression ◽  
Metastatic Spinal Cord Compression ◽  
Unknown Primary ◽  
Unknown Primary Tumour

scholarly journals Lymph Node Metastases in the Neck from Unknown Primary Tumour

1992 ◽  
Vol 31 (6) ◽  
pp. 653-655 ◽  
Author(s):  
John Jakobsen ◽  
Pia Aschenfeldt ◽  
Jørgen Johansen ◽  
Karsten Jørgensen
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastases ◽  
Primary Tumour ◽  
Unknown Primary ◽  
Unknown Primary Tumour ◽  
Node Metastases

scholarly journals Novel patient risk factors and validation of a difficulty scoring system in laparoscopic repeat hepatectomy

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Yukiyasu Okamura ◽  
Yusuke Yamamoto ◽  
Teiichi Sugiura ◽  
Takaaki Ito ◽  
Ryo Ashida ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Loss ◽  
Scoring System ◽  
Risk Group ◽  
Primary Tumour ◽  
Repeat Hepatectomy ◽  
Tumour Site ◽  
Blood Loss Volume ◽  
Lateral Sectionectomy ◽  
Primary Tumour Site

AbstractThe indications for laparoscopic liver resection have expanded; however, the safety and benefits of laparoscopic repeat hepatectomy (LRH) remain unclear. We retrospectively reviewed data from 137 patients who underwent partial hepatectomy or left lateral sectionectomy without thoracotomy. We compared patients’ clinical factors using a difficulty scoring system for LRH. We defined factors associated with blood loss volumes in the 75th percentile or above as risk factors for bleeding in open repeat hepatectomy, and determined whether these factors were useful for LRH risk assessment. Open repeat hepatectomy and LRH was performed in 96 and 41 patients, respectively. Four of 41 (9.8%) patients undergoing LRH were converted to laparotomy. Blood loss volume was significantly greater in the intermediate-risk group than in the low-risk group (P = 0.046). Multivariate analysis revealed that the presence of tumours located adjacent and caudal or dorsal to the primary tumour site was an independent risk factor for bleeding in LRH (odds ratio 3.21, 95% confidence interval 1.16–8.88, P = 0.024). Our study validated the usefulness of a difficulty scoring system, identified patient factors that predicted the difficulty of LRH, and presented a novel difficulty scoring system for LRH based on an existing difficulty scoring system.

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