Laparoscopic versus open liver resection: a meta‐analysis of long‐term outcome

We compare the value of TACE to liver resection for patients with BCLC stage A and B HCC. For patients with HCC in cirrhosis LT is the treatment of choice. TACE represents the current standard for unresectable BCLC stage B patients not eligible for LT. Recently liver resection for HCC and significant cirrhosis has become increasingly popular. A systematic search of the literature and meta-analysis was conducted to identify studies, reporting short- and long-term results of hepatic resection versus TACE for HCC treatment. The data were analyzed regarding the odds for 30-day mortality and hazard ratio for overall-survival. 12 studies comparing short- and long-term outcome of HR versus TACE for HCC were identified. Peri-interventional mortality and overall survival were investigated. Peri-interventional mortality was higher for surgical resection (n.s.), and overall-survival was significantly better for surgically treated patients at one year (P=0.002) and 3 years (P≤0.00001). The hazard ratio of overall-survival for all twelve studies was 0.70 (P=0.0001) and significantly in favor of surgical treatment. Although large RCTs are missing and the available data are limited and not homogeneous a reappraisal of the current treatment guidelines should be considered based on the superior long-term outcome for surgically treated patients.

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Find the Flame: Predictive Biomarkers for Immunotherapy in Melanoma

Cancers ◽

10.3390/cancers13081819 ◽

2021 ◽

Vol 13 (8) ◽

pp. 1819

Author(s):

Mattia Garutti ◽

Serena Bonin ◽

Silvia Buriolla ◽

Elisa Bertoli ◽

Maria Antonietta Pizzichetta ◽

...

Keyword(s):

Meta Analysis ◽

Tumor Biology ◽

Predictive Biomarkers ◽

Decision Making Process ◽

Checkpoint Inhibition ◽

Clinical Context ◽

Term Outcome ◽

Long Term Outcome ◽

Therapeutic Landscape

Immunotherapy has revolutionized the therapeutic landscape of melanoma. In particular, checkpoint inhibition has shown to increase long-term outcome, and, in some cases, it can be virtually curative. However, the absence of clinically validated predictive biomarkers is one of the major causes of unpredictable efficacy of immunotherapy. Indeed, the availability of predictive biomarkers could allow a better stratification of patients, suggesting which type of drugs should be used in a certain clinical context and guiding clinicians in escalating or de-escalating therapy. However, the difficulty in obtaining clinically useful predictive biomarkers reflects the deep complexity of tumor biology. Biomarkers can be classified as tumor-intrinsic biomarkers, microenvironment biomarkers, and systemic biomarkers. Herein we review the available literature to classify and describe predictive biomarkers for checkpoint inhibition in melanoma with the aim of helping clinicians in the decision-making process. We also performed a meta-analysis on the predictive value of PDL-1.

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1029 LONG-TERM OUTCOME OF CIRRHOTIC PATIENTS WITH SINGLE HCC ≤ 5CM. DOES LIVER RESECTION HAVE THE SAME RESULTS AS LIVER TRANSPLANTATION?

Journal of Hepatology ◽

10.1016/s0168-8278(12)61041-1 ◽

2012 ◽

Vol 56 ◽

pp. S402-S403

Author(s):

G. Sapisochin ◽

C. Dopazo ◽

I. Bilbao ◽

L. Castells ◽

J.L. Lazaro ◽

...

Keyword(s):

Liver Transplantation ◽

Liver Resection ◽

Term Outcome ◽

Long Term Outcome ◽

Cirrhotic Patients

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Biomarkers Predictive of Long-Term Outcome After Ischemic Stroke: A Meta-Analysis

World Neurosurgery ◽

10.1016/j.wneu.2021.10.157 ◽

2021 ◽

Author(s):

Sauson Soldozy ◽

Kaan Yağmurlu ◽

Pedro Norat ◽

Mazin Elsarrag ◽

John Costello ◽

...

Keyword(s):

Ischemic Stroke ◽

Meta Analysis ◽

Term Outcome ◽

Long Term Outcome

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Long-term outcome after liver resection and clinicopathological features in patients with small hepatocellular carcinoma

Korean Journal of Hepato-Biliary-Pancreatic Surgery ◽

10.14701/kjhbps.2011.15.4.199 ◽

2011 ◽

Vol 15 (4) ◽

pp. 199 ◽

Cited By ~ 3

Author(s):

Young Ju Hong ◽

Sung Hoon Kim ◽

Gi Hong Choi ◽

Kyung Sik Kim ◽

Jin Sub Choi

Keyword(s):

Hepatocellular Carcinoma ◽

Liver Resection ◽

Clinicopathological Features ◽

Small Hepatocellular Carcinoma ◽

Term Outcome ◽

Long Term Outcome

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Duration of untreated psychosis as predictor of long-term outcome in schizophrenia: systematic review and meta-analysis

The British Journal of Psychiatry ◽

10.1192/bjp.bp.113.127753 ◽

2014 ◽

Vol 205 (2) ◽

pp. 88-94 ◽

Cited By ~ 278

Author(s):

Matti Penttilä ◽

Erika Jääskeläinen ◽

Noora Hirvonen ◽

Matti Isohanni ◽

Jouko Miettunen

Keyword(s):

Negative Symptoms ◽

Meta Analysis ◽

Hospital Treatment ◽

Duration Of Untreated Psychosis ◽

Long Term Effects ◽

Term Outcome ◽

Long Term Outcome ◽

Positive Effects ◽

Early Intervention In Psychosis

BackgroundDuration of untreated psychosis (DUP) is one of the few potentially modifiable predictors of outcomes of schizophrenia. Long DUP as a predictor of poor short-term outcome has been addressed in previous meta-analyses, but the long-term effects of DUP remain unclear.AimsTo analyse the associations between DUP and long-term outcomes of schizophrenia.MethodA systematic literature search was performed using seven electronic databases and manual searches. Random effects weighted meta-analysis with correlation coefficients was used to pool the results.ResultsWe identified 3493 unique publications, from which 33 samples met our predefined selection criteria. Long DUP correlated statistically significantly with poor general symptomatic outcome, more severe positive and negative symptoms, lesser likelihood of remission and poor social functioning and global outcome (correlations 0.13–0.18). Long DUP was not associated with employment, quality of life or hospital treatment.ConclusionsThe small but mostly consistent correlation between long DUP and poor outcome indicates that early intervention in psychosis may have at least subtle positive effects on the long-term course of illness.

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