scholarly journals Duration of untreated psychosis as predictor of long-term outcome in schizophrenia: systematic review and meta-analysis

2014 ◽  
Vol 205 (2) ◽  
pp. 88-94 ◽  
Author(s):  
Matti Penttilä ◽  
Erika Jääskeläinen ◽  
Noora Hirvonen ◽  
Matti Isohanni ◽  
Jouko Miettunen
Keyword(s):  
Negative Symptoms ◽  
Meta Analysis ◽  
Hospital Treatment ◽  
Duration Of Untreated Psychosis ◽  
Long Term Effects ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Positive Effects ◽  
Early Intervention In Psychosis

BackgroundDuration of untreated psychosis (DUP) is one of the few potentially modifiable predictors of outcomes of schizophrenia. Long DUP as a predictor of poor short-term outcome has been addressed in previous meta-analyses, but the long-term effects of DUP remain unclear.AimsTo analyse the associations between DUP and long-term outcomes of schizophrenia.MethodA systematic literature search was performed using seven electronic databases and manual searches. Random effects weighted meta-analysis with correlation coefficients was used to pool the results.ResultsWe identified 3493 unique publications, from which 33 samples met our predefined selection criteria. Long DUP correlated statistically significantly with poor general symptomatic outcome, more severe positive and negative symptoms, lesser likelihood of remission and poor social functioning and global outcome (correlations 0.13–0.18). Long DUP was not associated with employment, quality of life or hospital treatment.ConclusionsThe small but mostly consistent correlation between long DUP and poor outcome indicates that early intervention in psychosis may have at least subtle positive effects on the long-term course of illness.

scholarly journals Find the Flame: Predictive Biomarkers for Immunotherapy in Melanoma

Cancers ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1819
Author(s):  
Mattia Garutti ◽  
Serena Bonin ◽  
Silvia Buriolla ◽  
Elisa Bertoli ◽  
Maria Antonietta Pizzichetta ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Tumor Biology ◽  
Predictive Biomarkers ◽  
Decision Making Process ◽  
Checkpoint Inhibition ◽  
Clinical Context ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Therapeutic Landscape

Immunotherapy has revolutionized the therapeutic landscape of melanoma. In particular, checkpoint inhibition has shown to increase long-term outcome, and, in some cases, it can be virtually curative. However, the absence of clinically validated predictive biomarkers is one of the major causes of unpredictable efficacy of immunotherapy. Indeed, the availability of predictive biomarkers could allow a better stratification of patients, suggesting which type of drugs should be used in a certain clinical context and guiding clinicians in escalating or de-escalating therapy. However, the difficulty in obtaining clinically useful predictive biomarkers reflects the deep complexity of tumor biology. Biomarkers can be classified as tumor-intrinsic biomarkers, microenvironment biomarkers, and systemic biomarkers. Herein we review the available literature to classify and describe predictive biomarkers for checkpoint inhibition in melanoma with the aim of helping clinicians in the decision-making process. We also performed a meta-analysis on the predictive value of PDL-1.

Biomarkers Predictive of Long-Term Outcome After Ischemic Stroke: A Meta-Analysis

2021 ◽  
Author(s):  
Sauson Soldozy ◽  
Kaan Yağmurlu ◽  
Pedro Norat ◽  
Mazin Elsarrag ◽  
John Costello ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Meta Analysis ◽  
Term Outcome ◽  
Long Term Outcome

scholarly journals Residual hip dysplasia: is there a place for hip shelf operation?

2018 ◽  
Vol 12 (4) ◽  
pp. 358-363 ◽  
Author(s):  
T. Terjesen
Keyword(s):  
Periacetabular Osteotomy ◽  
Developmental Dysplasia ◽  
Hip Pain ◽  
Older Children ◽  
Long Term Effects ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Shelf Procedure ◽  
Shelf Operation

Purpose After modern acetabular osteotomies were introduced, hip shelf operations have become much less commonly used. The aims of this study were to assess the short-term and long-term outcome of a modified Spitzy shelf procedure and to compare the results with those of periacetabular osteotomy (PAO). Methods In all, 44 patients (55 hips) with developmental dysplasia of the hip and residual dysplasia had a modified Spitzy shelf operation. Mean age at surgery was 13.2 years (8 to 22). Indication for surgery was a centre-edge angle < 20° with or without hip pain. Outcome was evaluated using duration of painless period and survival analysis with conversion to total hip arthroplasty (THA) as endpoints. Results Preoperative hip pain was present in 46% of the hips and was more common in patients ≥ 12 years at surgery (p < 0.001). One year postoperatively, 93% of the hips were painless. Analysis of pain in hips with more than ten years follow-up showed a mean postoperative painless period of 20.0 years (0 to 49). In all, 44 hips (80%) had undergone THA at a mean patient age of 50.5 years (37 to 63). Mean survival of the shelf procedure (time from operation to THA) was 39.3 years (21 to 55). Conclusions The Spitzy operation had good short and long-term effects on hip pain and a 30-year survival (no THA) of 72% of the hips. These results compare favourably with those of PAO and indicate that there is still a place for the shelf procedure in older children and young adults.

scholarly journals Laparoscopic versus open liver resection: a meta‐analysis of long‐term outcome

HPB ◽  
2014 ◽  
Vol 16 (2) ◽  
pp. 109-118 ◽  
Author(s):  
Kevin Ryan Parks ◽  
Yen‐Hong Kuo ◽  
John Mihran Davis ◽  
Brittany O' Brien ◽  
Ellen J. Hagopian
Keyword(s):  
Liver Resection ◽  
Meta Analysis ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Open Liver Resection

scholarly journals LONG-TERM OUTCOME OF PULMONARY VEIN ISOLATION WITH AND WITHOUT FOCAL IMPULSE AND ROTOR MODULATION (FIRM) MAPPING: RESULTS FROM A META-ANALYSIS

2017 ◽  
Vol 69 (11) ◽  
pp. 394 ◽  
Author(s):  
Sanghamitra Mohanty ◽  
Prasant Mohanty ◽  
Carola Gianni ◽  
Chintan Trivedi ◽  
Luigi Di Biase ◽  
...  
Keyword(s):  
Pulmonary Vein ◽  
Pulmonary Vein Isolation ◽  
Meta Analysis ◽  
Term Outcome ◽  
Long Term Outcome

Long-Term Stability of Diagnosis and Symptom Dimensions in a Systematic Sample of Patients with Onset of Schizophrenia in Childhood and Early Adolescence. II: Positive/Negative Distinction and Childhood Predictors of Adult Outcome

1996 ◽  
Vol 169 (3) ◽  
pp. 371-378 ◽  
Author(s):  
Michel Maziade ◽  
Stéphane Bouchard ◽  
Nathalie Gingras ◽  
Liliane Charron ◽  
Andrée Cardinal ◽  
...  
Keyword(s):  
Factor Analysis ◽  
Negative Symptoms ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Symptom Dimensions ◽  
Developmental Problems ◽  
Adult Outcome ◽  
Longitudinal Factor Analysis ◽  
Childhood Predictors

BackgroundThe aim of this study was to verify the presence and stability across life of the positive/negative distinction in early-onset schizophrenia (EO-SZ) through a longitudinal factor analysis of the schizophrenic dimensions, and to identify the factors predicting several indices of long-term outcome for EO-SZ.MethodForty children consecutively referred for DSM–III–R schizophrenia (SZ) in a specific catchment area comprised the sample.ResultsAcross a 14.8-year follow-up, longitudinal factor analysis identified two separate factors corresponding to the positive and negative symptom dimensions. We also observed that: the GAS rated over the last three years of adult illness and the severity of negative symptoms during the stabilised interepisode intervals in adulthood were the indices of adult outcome that were most easily predicted; and the best childhood predictors of adult outcome were premorbid functioning and severity of positive and negative symptoms during acute episodes.ConclusionsThe presence of premorbid non-psychotic behaviour disturbances (NPBD) and premorbid developmental problems was not related to severity of outcome, in contrast to the former variables.

scholarly journals Long-Term Effects of the Treatment of Depressive Female Inpatients in a Naturalistic Study: Is Early Improvement a Valid Predictor of Outcome?

2014 ◽  
Vol 2014 ◽  
pp. 1-8
Author(s):  
Elian Zuercher-Huerlimann ◽  
Martin grosse Holtforth ◽  
Ernst Hermann
Keyword(s):  
Binary Logistic Regression ◽  
Inpatient Setting ◽  
Long Term Effects ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Early Improvement ◽  
Valid Predictor ◽  
Short And Long Term

Objectives.To examine the predictive value of early improvement for short- and long-term outcome in the treatment of depressive female inpatients and to explore the influence of comorbid disorders (CD).Methods.Archival data of a naturalistic sample of 277 female inpatients diagnosed with a depressive disorder was analyzed assessing the BDI at baseline, after 20 days and 30 days, posttreatment, and after 3 to 6 months at follow-up. Early improvement, defined as a decrease in the BDI score of at least 30% after 20 and after 30 days, and CD were analyzed using binary logistic regression.Results.Both early improvement definitions were predictive of remission at posttreatment. Early improvement after 30 days showed a sustained treatment effect in the follow-up phase, whereas early improvement after 20 days failed to show a persistent effect regarding remission at follow-up. CD were not significantly related neither at posttreatment nor at follow-up. At no time point CD moderated the prediction by early improvement.Conclusions.We show that early improvement is a valid predictor for short-term remission and at follow-up in an inpatient setting. CD did not predict outcome. Further studies are needed to identify patient subgroups amenable to more tailored treatments.

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