Microneedle patch based on dissolving, detachable microneedle technology for improved skin quality of the periorbital region. Part 2: Clinical Evaluation

2020 ◽  
Vol 42 (5) ◽  
pp. 429-435
Author(s):  
V. Zvezdin ◽  
T. Kasatkina ◽  
I. Kasatkin ◽  
M. Gavrilova ◽  
O. Kazakova
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Miguel Ángel Amor-García ◽  
Sara Ibáñez-García ◽  
Xandra García-González ◽  
Teresa Mombiela ◽  
Cristina Villanueva-Bueno ◽  
...  

Abstract Background Patients with pulmonary hypertension (PH) have progressive and disabling symptoms, as well as a burden of treatments and a difficult clinical evaluation that make health-related quality of life a particularly relevant endpoint in this disease. The objective of the study was to evaluate patient-reported outcomes of patients receiving specific treatment for PH in a tertiary hospital using a specific questionnaire (Cambridge Pulmonary Hypertension Outcome Review-CAMPHOR) in the pharmacy consultation. Methods A cross-sectional, observational, descriptive study was conducted. It included all patients receiving specific treatment for PH in a tertiary hospital in Madrid, Spain. The inclusion period comprised between August to December 2019. CAMPHOR questionnaires containing three domains: symptoms, activities and quality of life were completed by the patients at the pharmacy consultation. Demographic and clinical variables, including WHO Functional Class (WHO FC), PH-specific tests and hemodynamic parameters, were recorded. Non-parametric analyses to assess relations between variables and CAMPHOR domains were performed. Results Thirty-six patients consented to participate in the study and completed the questionnaire. Median scores for symptoms, activities, and quality of life domains were 5.5 (2.5–10), 8.0 (4.5–10.5) and 3.5 (1–7.5), respectively. Statistically significant differences were found in the three domains when comparing by WHO FC, in the activities domain for 6-m walking test and in the quality of life domain for patients who had emergency visits or hospitalizations in the last year. Conclusions The CAMPHOR questionnaire could be useful as a complementary test to achieve an integrated evaluation of PH patients, who could complete it easily during their routine pharmacy visits.


2015 ◽  
Vol 89 (18) ◽  
pp. 9499-9510 ◽  
Author(s):  
Bo Liang ◽  
Sonja Surman ◽  
Emerito Amaro-Carambot ◽  
Barbora Kabatova ◽  
Natalie Mackow ◽  
...  

ABSTRACTRespiratory syncytial virus (RSV) and human parainfluenza virus type 3 (HPIV3) are the first and second leading viral agents of severe respiratory tract disease in infants and young children worldwide. Vaccines are not available, and an RSV vaccine is particularly needed. A live attenuated chimeric recombinant bovine/human PIV3 (rB/HPIV3) vector expressing the RSV fusion (F) glycoprotein from an added gene has been under development as a bivalent vaccine against RSV and HPIV3. Previous clinical evaluation of this vaccine candidate suggested that increased genetic stability and immunogenicity of the RSV F insert were needed. This was investigated in the present study. RSV F expression was enhanced 5-fold by codon optimization and by modifying the amino acid sequence to be identical to that of an early passage of the original clinical isolate. This conferred a hypofusogenic phenotype that presumably reflects the original isolate. We then compared vectors expressing stabilized prefusion and postfusion versions of RSV F. In a hamster model, prefusion F induced increased quantity and quality of RSV-neutralizing serum antibodies and increased protection against wild-type (wt) RSV challenge. In contrast, a vector expressing the postfusion F was less immunogenic and protective. The genetic stability of the RSV F insert was high and was not affected by enhanced expression or the prefusion or postfusion conformation of RSV F. These studies provide an improved version of the previously well-tolerated rB/HPIV3-RSV F vaccine candidate that induces a superior RSV-neutralizing serum antibody response.IMPORTANCERespiratory syncytial virus (RSV) and human parainfluenza virus type 3 (HPIV3) are two major causes of pediatric pneumonia and bronchiolitis. The rB/HPIV3 vector expressing RSV F protein is a candidate bivalent live vaccine against HPIV3 and RSV. Previous clinical evaluation indicated the need to increase the immunogenicity and genetic stability of the RSV F insert. Here, we increased RSV F expression by codon optimization and by modifying the RSV F amino acid sequence to conform to that of an early passage of the original isolate. This resulted in a hypofusogenic phenotype, which likely represents the original phenotype before adaptation to cell culture. We also included stabilized versions of prefusion and postfusion RSV F protein. Prefusion RSV F induced a larger quantity and higher quality of RSV-neutralizing serum antibodies and was highly protective. This provides an improved candidate for further clinical evaluation.


2008 ◽  
Vol 42 (8) ◽  
pp. 816-822 ◽  
Author(s):  
Nancy L Dudek ◽  
Meridith B Marks ◽  
Timothy J Wood ◽  
A Curtis Lee
Keyword(s):  

Author(s):  
Zahra Riahi Roohi ◽  
Shayesteh Salehi

Quality of nurse training programs requires clinical evaluation. The purpose of this study was to achieve a perspective of realities from viewpoint of nursing students during their internship and clerkship. This study was descriptive and quantitative; 180 nurse inters and nursing unit clerks were enrolled for the study. Data was collected using a researcher made questionnaire. Content validity of the questionnaire was confirmed by a group of faculty members and clinical professors; reliability of the questionnaire was confirmed by Cronbach's alpha (0.89). The questionnaire consisted of two parts; demographic data and data related to clinical evaluation in four areas including content of evaluation, the role of instructor in evaluation, evaluation process and outcome of evaluation. The questionnaire was scored on a five-point Likert scale from always to never. At the end, there were two open questions about suggestions on clinical evaluation. Data were analyzed by SPSS22, descriptive and analytic statistics. Results showed that nurse interns evaluated the instructor as good (4.05 ± 0.06), evaluation content as average (3.65 ± 0.06), evaluation process as average (2.77 ± 0.76) and outcome of evaluation as poor (2.41 ± 0.69). Nursing unit clerks evaluated the instructor as good (3.84 ± 0.59), evaluation content as average (3.51 ± 0.68), evaluation process as average (2.60 ± 0.78) and outcome of evaluation as poor (2.56 ± 0.63). According to the results, quality of clinical evaluation of nursing students requires a review in existing processes and tools, as well as revision in programs and clinical evaluations by planners and instructors.


2018 ◽  
pp. 40-46
Author(s):  
N.I. Mykyievych

Introduction. Critical review of the available medical scientific sources demonstrates that despite the wide range of advantages, photopolymer composite materials have certain disadvantages. The main of those are contraction during polymerization and incomplete polymerization of the filling volume. These disadvantages cause the crevice between the direct restoration and the tooth wall, the possible discoloration can reduce tooth hardness. Some researchers recommend the application of inlays in order to prevent complications while restoring caries cavities in posterior teeth. Complete polymerization and reliable adjacency to dental tissues ensure sustainability of indirect photopolymer restoration and prevent secondary caries in restored areas. Objective. The study is aimed at raising the effectiveness of dental treatment by clinical evaluation of the quality of direct and indirect restorations made from composite materials. Methods and Materials. In order to conduct comparative clinical evaluation 90 patients with defects of coronal part of lateral teeth, aged 19-54 have been examined, who have orthognathic occlusion, don’t have dental and facial malformations or muscular and joint dysfunctions. They underwent 189 restorations of lateral teeth with cavities of O, MO, OD, MOD types due to medium or severe caries or because of dissatisfying condition of the previously inserted fillings. The patients were divided into two groups according to the method of treatment. The I (basic) group included 42 patients, who underwent 76 indirect restorations for reconstructing the defects of teeth crowns. The II (test) group included 54 patients, who underwent 113 direct restorations for reconstructing the defects of teeth crowns. Each group was subdivided into two subgroups. The patients who underwent 38 indirect restorations with photopolymer composite material Filtek Z 250 (3M ESPE) were placed in the subgroup I A, the patients who underwent 38 indirect restorations with material Charisma (Heraeus Kulzer) were placed in the subgroup I B. The patients who underwent 57 direct restorations with photopolymer composite material Filtek Z 250 (3M ESPE) were placed in the subgroup II A, the patients who underwent 56 direct restorations with material Charisma (Heraeus Kulzer) were placed in the subgroup II B. Clinical efficiency of both direct and indirect restorations was evaluated immediately after their application and then after 12 and 24 months with the help of visual and instrumental examination. When secondary caries was suspected, the target X-rays were taken with Heliodent Vario (Sirona). The evaluation was conducted according to the Ryge criteria (1998), approved by USPHS (United States Public Health Service). They include the following indicators: anatomic contour, marginal integrity and marginal coloration, secondary caries, surface texture, preservation of the restoration, restoration fracture, crevice at the edge of restoration, restoration abrasion, tooth fracture, no approximal adjacency, overhanging restoration, localized gingivitis. Results. The comparative analysis of the clinical efficiency of lateral teeth restorations made from photopolymer materials under study revealed significantly higher quality of indirect restorations (composite inlays), which demonstrated good clinical results even in long-term perspective. Only 5,3% of patients with indirect restorations (with both Filtek Z 250 and Charisma) underwent partial restoration in order to prevent further destruction. By contrast, the patients with direct restorations required the partial restoration in 7% with Filtek Z 250 and 8,9% with Charisma and needed immediate replacement of fillings in 10,5% and 17,8% correspondingly.


Author(s):  
Raluca-Mariana Popa

The objective of the following research is the investigation of the impact that management of dysphagia has upon quality of life in persons with neurological pathology of vascular cerebreal attack type. The group of participants in this study has 6 members with ages between 34 and 69, all suffering from a neurological pathology of VCA type or cranio-cerebreal trauma with direct implications on the swallowing process. This paper used case study methode as experimental design, the goal being to detect the impact that speach therapy has on the dysphagia, in the context of safety and quality of life. A series of instruments regarding clinical evaluation of dysphagia and quality of life in the context of VCA and dysphagia where been translated and adapted in the fallowing research.


1991 ◽  
Vol 6 (2) ◽  
pp. 129-135 ◽  
Author(s):  
V. Capstick ◽  
G.D. Maclean ◽  
M.R. Suresh ◽  
D. Bodnar ◽  
S. Lloyd ◽  
...  

As appropriate surgery and chemotherapy can improve both quality of life and survival of patients with ovarian adenocarcinoma, there has been a pressing need for “serodiagnostic” assays to enable close patient monitoring. CA 125 antigen has previously been described as a useful tumor marker of ovarian cancer. This is the first clinical evaluation of a radioimmunoassay using two new monoclonal antibodies, B27.1 and B43.13, that react with separate sites on the glycoprotein marker CA 125. Using the new assay, the majority of patients with clinically or radiologically detectable disease had serum CA 125 antigen levels well above the upper limit seen with random apparently healthy donors, while only three patients who were believed free of disease had elevated levels. Disease progression was associated with increasing values of serum CA 125 antigen, while response to therapy was associated with a steady decline in serum CA 125 antigen levels. Seven patients had steadily rising serum CA 125 antigen levels after initially having normal levels. The mean lead time between rise above normal and clinical or radiological evidence of relapse was 5 months (range 2 to 12 months). The merits of further surgical intervention are illustrated by the serial values of two patients followed after chemotherapy. The assay appears to have value in monitoring response to therapy and in detecting disease relapse at a time when appropriate therapeutic intervention is still possible or likely to be beneficial. Furthermore, monitoring CA 125 antigen was shown to be of benefit in assessing response to chemotherapy in a few patients with metastatic adenocarcinoma of unknown primary, and may be useful in this group of patients in determining those likely to benefit from aggressive chemotherapy.


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