scholarly journals The effect of topical virgin coconut oil on SCORAD index, transepidermal water loss, and skin capacitance in mild to moderate pediatric atopic dermatitis: a randomized, double-blind, clinical trial

2013 ◽  
Vol 53 (1) ◽  
pp. 100-108 ◽  
Author(s):  
Mara Therese Padilla Evangelista ◽  
Flordeliz Abad-Casintahan ◽  
Lillian Lopez-Villafuerte
Keyword(s):  
Clinical Trial ◽  
Atopic Dermatitis ◽  
Water Loss ◽  
Coconut Oil ◽  
Transepidermal Water Loss ◽  
Virgin Coconut Oil ◽  
Double Blind ◽  
Double Blind Clinical Trial ◽  
Skin Capacitance

Role of Centella asiatica and ceramide in skin barrier improvement: a double blind clinical trial of Indonesian batik workers

2021 ◽  
Vol 32 (4) ◽  
pp. 589-593
Author(s):  
Sylvia Anggraeni ◽  
Menul Ayu Umborowati ◽  
Damayanti Damayanti ◽  
Anang Endaryanto ◽  
Cita Rosita Sigit Prakoeswa
Keyword(s):  
Clinical Trial ◽  
Contact Dermatitis ◽  
Stratum Corneum ◽  
Skin Barrier ◽  
Centella Asiatica ◽  
Transepidermal Water Loss ◽  
Double Blind ◽  
Stratum Corneum Hydration ◽  
Double Blind Clinical Trial

Abstract Objectives Batik dyes contain irritant chemicals that increase the risk of skin barrier disruption. This study aims to determine the effect of Centella asiatica and ceramide in transepidermal water loss (TEWL), hydration of the stratum corneum and skin acidity (pH). Methods This was a double blind clinical trial of 30 Indonesian batik workers who suffered from skin dryness, but had no clinical manifestation of contact dermatitis. Subjects were given cream containing C. asiatica or ceramide that formulated and randomly labeled by manufacturer (PT Paragon Technology and Innovation). Both subjects and researchers were blinded to the type of the cream. Cream was applied to the hands and arms twice a day. Biological function of the skin (TEWL, stratum corneum hydration level, and skin acidity) was examined by Cutometer dual MP-580. Baseline was recorded in the first examination, followed by second and third examinations at two and four weeks after treatment. Results After four weeks treatment, there were significant improvement of C. asiatica application in evaluation of corneometer palmar (p=0.007; CI 95%), corneometer dorsum (p=0.001; CI 95%), and skin acidity dorsum (p=0.017; CI 95%). Ceramide application also gave significant improvement of corneometer palmar (0.038; CI 95%), skin acidity palmar (p=0.001; CI 95%), TEWL dorsum (p=0.023; CI 95%), corneometer dorsum (p=0.002; CI 95%) and skin acidity dorsum (p=0.011; CI 95%). There were no significant differences of C. asiatica effectiveness compared to ceramide in skin barrier improvement. Conclusions C. asiatica and ceramide can improve skin barrier hydration in order to prevent the risk of contact dermatitis in batik workers.

TOPICAL COCONUT OIL APPLICATION REDUCES TRANSEPIDERMAL WATER LOSS IN PRETERM VERY LOW BIRTH WEIGHT NEONATES: A RANDOMIZED CLINICAL TRIAL

PEDIATRICS ◽  
2008 ◽  
Vol 121 (Supplement 2) ◽  
pp. S139.2-S139 ◽  
Author(s):  
Sushma Nangia ◽  
Vinod Paul ◽  
Deepak Chawla ◽  
Ashok Deorari
Keyword(s):  
Clinical Trial ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Randomized Clinical Trial ◽  
Water Loss ◽  
Very Low Birth Weight ◽  
Coconut Oil ◽  
Transepidermal Water Loss

Analgesic Effect of Nebulized Versus Intravenous Fentanyl for Pain Relief of Limb Fracture: A Double-Blind Clinical Trial

2017 ◽  
Vol 11 (1) ◽  
pp. 101-106
Author(s):  
Mohammadreza Maleki Verki ◽  
Kambiz Masoumi ◽  
Hassan Motamed ◽  
Meisam Moezi ◽  
Arash Forouzan ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Pain Relief ◽  
Normal Saline ◽  
Pain Level ◽  
Fentanyl Citrate ◽  
Double Blind ◽  
Intravenous Fentanyl ◽  
Limb Fracture ◽  
Double Blind Clinical Trial ◽  
Fentanyl Group

Background:More than half of the patients attending emergency centers need analgesics. Injectable analgesics are currently the most common pain control strategy, but entail complications. Fentanyl is one of the most commonly used pain-relief opiates available in various forms.Objective:The present study aims to compare analgesic effects of nebulized against intravenous fentanyl for controlling pain due to limb fracture.Method:The present double-blind clinical trial recruited 213 patients presenting with fractured limbs to emergency departments. The first group of patients received 1 micg/kg of intravenous fentanyl citrate from a solution of 50 micg/ml and 5 ml of normal saline in nebulized form (group A), and the second group intravenously received 5 ml of normal saline and 4 micg/kg of 50 micg/ml solution of fentanyl citrate in nebulized form, whose volume reached 5 ml with the addition of normal saline (group B). Then, pain level was frequently measured and compared in the two groups for 20 minutes.Results:The results obtained showed reduced pain level in both the groups. However, point-by-point comparison of pain in the two groups revealed significantly greater pain reduction in intravenous fentanyl group (P<0.001). The need for adjuvant pain relief medication was 8.3% in intravenous fentanyl group and 24% in nebulized fentanyl group, with a significant difference between the two groups (P=0.002).Conclusion:According to the results, although nebulized fentanyl is effective in controlling pain due to limb fracture, it was less effective than intravenous type, and unable to control pain in many cases.

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