scholarly journals Sulfasalazine augments a pro-inflammatory response in interleukin-1β-stimulated amniocytes and myocytes

Immunology ◽  
2015 ◽  
Vol 146 (4) ◽  
pp. 630-644 ◽  
Author(s):  
Lynne Sykes ◽  
Kacie R. Thomson ◽  
Emily J. Boyce ◽  
Yun S. Lee ◽  
Zahirrah B. M. Rasheed ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Interleukin 1Β

scholarly journals POPing the fire into the pyrin?

2003 ◽  
Vol 373 (1) ◽  
pp. e1-e2
Author(s):  
Sanjeev MARIATHASAN ◽  
Domagoj VUCIC
Keyword(s):  
Inflammatory Response ◽  
Adaptor Proteins ◽  
Nuclear Factor Κb ◽  
Scaffold Proteins ◽  
Interleukin 1Β ◽  
Nuclear Factor ◽  
Complex Assembly ◽  
Inflammatory Disorders ◽  
Pyrin Domain ◽  
Biochemical Journal

Initiation of an inflammatory response requires the co-ordinated participation of proteins within a scaffold in the cytosol of responding cells. The scaffold proteins contain members of a newly discovered family of pyrin-domain adaptor proteins that regulate complex assembly for initiation of nuclear factor κB and interleukin-1β signalling. A paper in this issue of the Biochemical Journal by Stehlik et al. identifies a new member of the pyrin family that may control signalling by sequestering pro-inflammatory components, shedding light on the origin of human inflammatory disorders.

scholarly journals Interleukin-1β Promotes Ovarian Tumorigenesis through a p53/NF-κB-Mediated Inflammatory Response in Stromal Fibroblasts

Neoplasia ◽  
2013 ◽  
Vol 15 (4) ◽  
pp. 409-IN18 ◽  
Author(s):  
Isaiah Gregory Schauer ◽  
Jing Zhang ◽  
Zhen Xing ◽  
Xiaoqing Guo ◽  
Imelda Mercado-Uribe ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Interleukin 1Β ◽  
Stromal Fibroblasts ◽  
Ovarian Tumorigenesis

Interleukin-1β is prominent in the early pulmonary inflammatory response after hepatic injury

Surgery ◽  
2005 ◽  
Vol 138 (1) ◽  
pp. 64-70 ◽  
Author(s):  
Sean C. Glasgow ◽  
Sabarinathan Ramachandran ◽  
Krista A. Csontos ◽  
Jianluo Jia ◽  
Thalachallour Mohanakumar ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Hepatic Injury ◽  
Interleukin 1Β ◽  
Pulmonary Inflammatory Response

scholarly journals Acidosis Potentiates the Host Proinflammatory Interleukin-1β Response to Pseudomonas aeruginosa Infection

2014 ◽  
Vol 82 (11) ◽  
pp. 4689-4697 ◽  
Author(s):  
Iviana M. Torres ◽  
Yash R. Patankar ◽  
Tamer B. Shabaneh ◽  
Emily Dolben ◽  
Deborah A. Hogan ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Inflammatory Response ◽  
Inflammatory Responses ◽  
Interleukin 1Β ◽  
Acidic Environment ◽  
Content Type ◽  
Inflammatory Damage ◽  
Pseudomonas Aeruginosa Infection ◽  
Peritonitis Model

ABSTRACTInfection byPseudomonas aeruginosa, and bacteria in general, frequently promotes acidification of the local microenvironment, and this is reinforced by pulmonary exertion and exacerbation. However, the consequence of an acidic environment on the host inflammatory response toP. aeruginosainfection is poorly understood. Here we report that the pivotal cellular and host proinflammatory interleukin-1β (IL-1β) response, which enables host clearance of the infection but can produce collateral inflammatory damage, is increased in response toP. aeruginosainfection within an acidic environment. Synergistic mechanisms that promote increased IL-1β release in response toP. aeruginosainfection in an acidic environment are increased pro-IL-1β induction and increased caspase-1 activity, the latter being dependent upon a functional type III secretion system of the bacteria and the NLRC4 inflammasome of the host. Using anin vivoperitonitis model, we have validated that the IL-1β inflammatory response is increased in mice in response toP. aeruginosainfection within an acidic microenvironment. These data reveal novel insights into the regulation and exacerbation of inflammatory responses toP. aeruginosa.

The acute inflammatory response induced in mice by the venom of the giant ant Dinoponera quadriceps involves macrophage and interleukin-1β

Toxicon ◽  
2016 ◽  
Vol 117 ◽  
pp. 22-29 ◽  
Author(s):  
Paloma L. Sousa ◽  
Yves P. Quinet ◽  
Luiz André Cavalcante Brizeno ◽  
Tiago Lima Sampaio ◽  
Alba Fabíola C. Torres ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Interleukin 1Β ◽  
Acute Inflammatory Response

scholarly journals Author response: Transient inflammatory response mediated by interleukin-1β is required for proper regeneration in zebrafish fin fold

2017 ◽  
Author(s):  
Tomoya Hasegawa ◽  
Christopher J Hall ◽  
Philip S Crosier ◽  
Gembu Abe ◽  
Koichi Kawakami ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Interleukin 1Β ◽  
Author Response
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