POPing the fire into the pyrin?
Keyword(s):
Initiation of an inflammatory response requires the co-ordinated participation of proteins within a scaffold in the cytosol of responding cells. The scaffold proteins contain members of a newly discovered family of pyrin-domain adaptor proteins that regulate complex assembly for initiation of nuclear factor κB and interleukin-1β signalling. A paper in this issue of the Biochemical Journal by Stehlik et al. identifies a new member of the pyrin family that may control signalling by sequestering pro-inflammatory components, shedding light on the origin of human inflammatory disorders.
2020 ◽
Vol 48
(12)
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pp. 030006052098094
2001 ◽
Vol 280
(6)
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pp. G1296-G1304
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2003 ◽
Vol 353
(2)
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pp. 79-82
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2018 ◽
Vol 120
(2)
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pp. 1763-1772
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1999 ◽
Vol 57
(3)
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pp. 388-398
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2004 ◽
Vol 52
(3)
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pp. 218-223
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2004 ◽
Vol 75
(2)
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pp. 249-259
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