scholarly journals Regulatory T‐cells promote pulmonary repair by modulating T helper cell immune responses in lipopolysaccharide‐induced acute respiratory distress syndrome

Immunology ◽  
2019 ◽  
Vol 157 (2) ◽  
pp. 151-162 ◽  
Author(s):  
Wen Tan ◽  
Chaoji Zhang ◽  
Jianzhou Liu ◽  
Qi Miao
Keyword(s):  
T Cells ◽  
Acute Respiratory Distress Syndrome ◽  
Regulatory T Cells ◽  
Immune Responses ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
T Helper Cell ◽  
Helper Cell ◽  
T Helper

scholarly journals CD4+ CD25+ Regulatory T Cells Control T Helper Cell Type 1 Responses to Foreign Antigens Induced by Mature Dendritic Cells In Vivo

2003 ◽  
Vol 198 (2) ◽  
pp. 259-266 ◽  
Author(s):  
Guillaume Oldenhove ◽  
Magali de Heusch ◽  
Georgette Urbain-Vansanten ◽  
Jacques Urbain ◽  
Charlie Maliszewski ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Regulatory T Cells ◽  
Immune Responses ◽  
Peripheral Tolerance ◽  
T Helper Cell ◽  
Helper Cell ◽  
T Helper

Recent evidence suggests that in addition to their well known stimulatory properties, dendritic cells (DCs) may play a major role in peripheral tolerance. It is still unclear whether a distinct subtype or activation status of DC exists that promotes the differentiation of suppressor rather than effector T cells from naive precursors. In this work, we tested whether the naturally occurring CD4+ CD25+ regulatory T cells (Treg) may control immune responses induced by DCs in vivo. We characterized the immune response induced by adoptive transfer of antigen-pulsed mature DCs into mice depleted or not of CD25+ cells. We found that the development of major histocompatibility complex class I and II–restricted interferon γ–producing cells was consistently enhanced in the absence of Treg. By contrast, T helper cell (Th)2 priming was down-regulated in the same conditions. This regulation was independent of interleukin 10 production by DCs. Of note, splenic DCs incubated in vitro with Toll-like receptor ligands (lipopolysaccharide or CpG) activated immune responses that remained sensitive to Treg function. Our data further show that mature DCs induced higher cytotoxic activity in CD25-depleted recipients as compared with untreated hosts. We conclude that Treg naturally exert a negative feedback mechanism on Th1-type responses induced by mature DCs in vivo.

scholarly journals Phenotype of SARS-CoV-2-specific T-cells in COVID-19 patients with acute respiratory distress syndrome

2020 ◽  
Author(s):  
Daniela Weiskopf ◽  
Katharina S. Schmitz ◽  
Matthijs P. Raadsen ◽  
Alba Grifoni ◽  
Nisreen M.A. Okba ◽  
...  
Keyword(s):  
T Cells ◽  
Acute Respiratory Distress Syndrome ◽  
Immune Responses ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
Protein S ◽  
Cellular Immune Responses ◽  
Cellular Immune ◽  
Th1 Cytokines

AbstractCOVID-19 is associated with lymphopenia and ‘cytokine storm’, but no information is available on specific cellular immune responses to SARS-CoV-2. Here, we characterized SARS-CoV-2-specific CD4+ and CD8+ T-cells in patients with acute respiratory distress syndrome. The spike protein (S) proved a potent T-cell antigen and specific T-cells predominantly produced Th1 cytokines. These novel data are important in vaccine design and will facilitate evaluation of vaccine candidate immunogenicity.

scholarly journals Interleukin-33-Dependent Accumulation of Regulatory T Cells Mediates Pulmonary Epithelial Regeneration During Acute Respiratory Distress Syndrome

2021 ◽  
Vol 12 ◽  
Author(s):  
Wen Tan ◽  
Bohan Zhang ◽  
Xinpei Liu ◽  
Chaoji Zhang ◽  
Jianzhou Liu ◽  
...  
Keyword(s):  
T Cells ◽  
Acute Respiratory Distress Syndrome ◽  
Regulatory T Cells ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Treg Cell ◽  
Distress Syndrome ◽  
Treg Cells ◽  
Epithelial Regeneration ◽  
Tgf Β1

Acute respiratory distress syndrome (ARDS) triggered mostly by infection, is a syndrome that involves respiratory failure. ARDS induces strong local infiltration of regulatory T cells (Treg cells) in the lungs, and Treg cells were recently highlighted as being related to the repair of various tissue. However, at present, there is still a lack of adequate evidence showing the impact of Treg cells on pulmonary regeneration during ARDS. Here, we verified that Treg cells are strongly induced in ARDS mice and Treg depletion results in impaired lung repair. Moreover, Treg cells show high expression of ST2, a cellular receptor for the tissue alarmin IL-33, which is strongly upregulated in the lung during ARDS. In addition, we demonstrated that IL-33 signaling is crucial for Treg cell accumulation, and ST2-blocked mice show a decrease in the Treg cell population. Critically, transfer of exogenous IL-33 into Treg depleted mice restored Treg cells and facilitated lung regeneration by promoting alveolar type II cell (AEC2) recovery in ARDS, with elevated neutrophils infiltration and upregulated TGF-β1 release. These results emphasized the importance of IL-33 in accelerating the expansion of pulmonary Treg cells and promoting their activity to mediate pulmonary epithelial regeneration during ARDS in a TGF-β1-dependent manner.

scholarly journals Regulatory T Cells for Treating Patients With COVID-19 and Acute Respiratory Distress Syndrome: Two Case Reports

2020 ◽  
Vol 173 (10) ◽  
pp. 852-853 ◽  
Author(s):  
Douglas E. Gladstone ◽  
Bo Soo Kim ◽  
Kathy Mooney ◽  
Andrew H. Karaba ◽  
Franco R. D'Alessio
Keyword(s):  
T Cells ◽  
Acute Respiratory Distress Syndrome ◽  
Regulatory T Cells ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
Case Reports
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