scholarly journals Effectiveness of seasonal influenza vaccine in preventing medically attended influenza infection in England and Wales during the 2010/2011 season: a primary care-based cohort study

2013 ◽  
Vol 7 (6) ◽  
pp. 1175-1180 ◽  
Author(s):  
George Kafatos ◽  
Richard Pebody ◽  
Nick Andrews ◽  
Hayley Durnall ◽  
Michele Barley ◽  
...  
Keyword(s):  
Primary Care ◽  
Cohort Study ◽  
Influenza Vaccine ◽  
Seasonal Influenza ◽  
Influenza Infection ◽  
England And Wales ◽  
Seasonal Influenza Vaccine

scholarly journals Effectiveness of influenza vaccine among health care personnel in Thailand, 2018/19 season

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
T Eamchotchawalit ◽  
P Piyaraj ◽  
P Narongdej ◽  
S Charoensakulchai ◽  
C Chanthowong
Keyword(s):  
Health Care ◽  
Influenza Vaccine ◽  
Influenza Vaccination ◽  
Seasonal Influenza ◽  
Influenza Season ◽  
Influenza Infection ◽  
Vaccine Effectiveness ◽  
Health Care Personnel ◽  
Seasonal Influenza Vaccine ◽  
Influenza Like Illness

Abstract Background Influenza vaccination is the most effective way of preventing influenza infections and it is recommended for the entire health care personnel in Thailand. However, the evidence of influenza vaccine effectiveness (VE) among health care personnel is lacking in Thailand. The objective of this study was to estimate influenza vaccine effectiveness (VE) against laboratory confirmed medically attended influenza illness for the 2018/9 season among health care personnel who at risk for influenza infection in Bangkok, the capital of Thailand. Methods Throat swab specimens were collected from patients with influenza-like illness (ILI) presenting to outpatient clinics and tested for influenza virus by RT-PCR, between October 2018 and September 2019. A test-negative case-control design was used to estimate influenza VE against medically-attended laboratory-confirmed influenza in outpatient settings. Cases were influenza-like illness (ILI) patients who tested positive for influenza, and controls were influenza negative patients. Results During the 2018/19 season 373 samples were collected; 57 (15.3%) were positive for influenza, 70.2% A un-subtyped and 29.8% B. Adjusted VE against all influenza viruses for this influenza season was -31.7% (95% confidence interval (CI): -40.2 to 66.4), against influenza A un-subtyped, it was 43.9% (95% CI: -30.6 to 75.9) and against influenza B, it was 52.0% (95% CI: (-73.9 to 86.8). Conclusions The seasonal influenza vaccine was moderately effective against medically attended lab-confirmed influenza infection in health care personnel in Bangkok, Thailand in the 2018-19 influenza season. Key messages The seasonal influenza vaccine was moderately effective against medically attended lab-confirmed influenza infection in health care personnel in Bangkok. Increasing seasonal influenza vaccination among health care personnel in Thailand may decrease medically attended influenza-associated ILI cases in this population.

scholarly journals Early estimates of 2016/17 seasonal influenza vaccine effectiveness in primary care in France

2017 ◽  
Vol 95 ◽  
pp. 1-4 ◽  
Author(s):  
Cécile Souty ◽  
Ana-Maria Vilcu ◽  
Lisandru Capai ◽  
Sylvie van der Werf ◽  
Martine Valette ◽  
...  
Keyword(s):  
Primary Care ◽  
Influenza Vaccine ◽  
Seasonal Influenza ◽  
Vaccine Effectiveness ◽  
Seasonal Influenza Vaccine

scholarly journals Seasonal influenza vaccination and the risk of infection with pandemic influenza: a possible illustration of non-specific temporary immunity following infection

2010 ◽  
Vol 15 (47) ◽  
Author(s):  
H Kelly ◽  
S Barry ◽  
K Laurie ◽  
G Mercer
Keyword(s):  
Influenza Vaccine ◽  
Pandemic Influenza ◽  
Influenza A ◽  
Seasonal Influenza ◽  
Influenza Infection ◽  
Risk Of Infection ◽  
Seasonal Influenza Vaccine ◽  
Influenza A H1n1 ◽  
Seasonal Infection ◽  
Temporary Immunity

Four Canadian studies have suggested that receipt of seasonal influenza vaccine increased the risk of laboratory-confirmed infection with 2009 pandemic influenza A(H1N1). During the influenza season of 2009 in Victoria, Australia, this virus comprised 97% of all circulating influenza viruses for which sub-typing was available. We found no evidence that seasonal influenza vaccine increased the risk of, or provided protection against, infection with the pandemic virus. Ferret experiments have suggested protection against pandemic influenza A(H1N1) 2009 from multiple prior seasonal influenza infections but not from prior seasonal vaccination. Modelling studies suggest that influenza infection leads to heterosubtypic temporary immunity which is initially almost complete. We suggest these observations together can explain the apparent discrepant findings in Canada and Victoria. In Victoria there was no recent prior circulation of seasonal influenza and thus no temporary immunity to pandemic influenza. There was no association of seasonal influenza vaccine with pandemic influenza infection. In Canada seasonal influenza preceded circulation of the pandemic virus. An unvaccinated proportion of the population developed temporary immunity to pandemic influenza from seasonal infection but a proportion of vaccinated members of the population did not get seasonal infection and hence did not develop temporary immunity to pandemic influenza. It may therefore have appeared as if seasonal vaccination increased the risk of infection with pandemic influenza A(H1N1) virus.

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