scholarly journals Defining the seasonality of respiratory syncytial virus around the world: National and subnational surveillance data from 12 countries

2021 ◽  
Author(s):  
Lisa Staadegaard ◽  
Saverio Caini ◽  
Sonam Wangchuk ◽  
Binay Thapa ◽  
Walquiria Aparecida Ferreira Almeida ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Surveillance Data ◽  
The World ◽  
Syncytial Virus

scholarly journals Epidemiology and Seasonality of Childhood Respiratory Syncytial Virus Infections in the Tropics

Viruses ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 696
Author(s):  
Manika Suryadevara ◽  
Joseph B. Domachowske
Keyword(s):  
Respiratory Syncytial Virus ◽  
Developed Countries ◽  
Surveillance Data ◽  
Virus Infections ◽  
Tropical Regions ◽  
Tropical Asia ◽  
Treatment And Prevention ◽  
The World ◽  
Health Initiatives ◽  
Syncytial Virus

Infections caused by respiratory syncytial virus (RSV) are a major cause of morbidity and mortality in young children worldwide. Understanding seasonal patterns of region-specific RSV activity is important to guide resource allocation for existing and future treatment and prevention strategies. The decades of excellent RSV surveillance data that are available from the developed countries of the world are incredibly instructive in advancing public health initiatives in those regions. With few exceptions, these developed nations are positioned geographically across temperate regions of the world. RSV surveillance across tropical regions of the world has improved in recent years, but remains spotty, and where available, still lacks the necessary longitudinal data to determine the amount of seasonal variation expected over time. However, existing and emerging data collected across tropical regions of the world do indicate that patterns of infection are often quite different from those so well described in temperate areas. Here, we provide a brief summary regarding what is known about general patterns of RSV disease activity across tropical Asia, Africa and South America, then offer additional country-specific details using examples where multiple reports and/or more robust surveillance data have become available.

scholarly journals Use of the moving epidemic method (MEM) to assess national surveillance data for respiratory syncytial virus (RSV) in the Netherlands, 2005 to 2017

2019 ◽  
Vol 24 (20) ◽  
Author(s):  
Laura M Vos ◽  
Anne C Teirlinck ◽  
José E Lozano ◽  
Tomás Vega ◽  
Gé A Donker ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
The Netherlands ◽  
Respiratory Infections ◽  
Laboratory Data ◽  
Age Distribution ◽  
Age Groups ◽  
Surveillance Data ◽  
Cumulative Number ◽  
Laboratory Surveillance ◽  
Syncytial Virus

Background To control respiratory syncytial virus (RSV), which causes acute respiratory infections, data and methods to assess its epidemiology are important. Aim We sought to describe RSV seasonality, affected age groups and RSV-type distribution over 12 consecutive seasons in the Netherlands, as well as to validate the moving epidemic method (MEM) for monitoring RSV epidemics. Methods We used 2005−17 laboratory surveillance data and sentinel data. For RSV seasonality evaluation, epidemic thresholds (i) at 1.2% of the cumulative number of RSV-positive patients per season and (ii) at 20 detections per week (for laboratory data) were employed. We also assessed MEM thresholds. Results In laboratory data RSV was reported 25,491 times (no denominator). In sentinel data 5.6% (767/13,577) of specimens tested RSV positive. Over 12 seasons, sentinel data showed percentage increases of RSV positive samples. The average epidemic length was 18.0 weeks (95% confidence intervals (CI):  16.3–19.7) and 16.5 weeks (95% CI: 14.0–18.0) for laboratory and sentinel data, respectively. Epidemics started on average in week 46 (95% CI: 45–48) and 47 (95% CI:  46–49), respectively. The peak was on average in the first week of January in both datasets. MEM showed similar results to the other methods. RSV incidence was highest in youngest (0–1 and >1–2 years) and oldest (>65–75 and > 75 years) age groups, with age distribution remaining stable over time. RSV-type dominance alternated every one or two seasons. Conclusions Our findings provide baseline information for immunisation advisory groups. The possibility of employing MEM to monitor RSV epidemics allows prospective, nearly real-time use of surveillance data.

scholarly journals Local Evolutionary Patterns of Human Respiratory Syncytial Virus Derived from Whole-Genome Sequencing

2015 ◽  
Vol 89 (7) ◽  
pp. 3444-3454 ◽  
Author(s):  
Charles N. Agoti ◽  
James R. Otieno ◽  
Patrick K. Munywoki ◽  
Alexander G. Mwihuri ◽  
Patricia A. Cane ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Large Scale ◽  
Vaccine Development ◽  
Human Respiratory Syncytial Virus ◽  
Genomic Variation ◽  
Genomic Sequences ◽  
The Novel ◽  
Sequencing Method ◽  
The World ◽  
Syncytial Virus

ABSTRACTHuman respiratory syncytial virus (RSV) is associated with severe childhood respiratory infections. A clear description of local RSV molecular epidemiology, evolution, and transmission requires detailed sequence data and can inform new strategies for virus control and vaccine development. We have generated 27 complete or nearly complete genomes of RSV from hospitalized children attending a rural coastal district hospital in Kilifi, Kenya, over a 10-year period using a novel full-genome deep-sequencing process. Phylogenetic analysis of the new genomes demonstrated the existence and cocirculation of multiple genotypes in both RSV A and B groups in Kilifi. Comparison of local versus global strains demonstrated that most RSV A variants observed locally in Kilifi were also seen in other parts of the world, while the Kilifi RSV B genomes encoded a high degree of variation that was not observed in other parts of the world. The nucleotide substitution rates for the individual open reading frames (ORFs) were highest in the regions encoding the attachment (G) glycoprotein and the NS2 protein. The analysis of RSV full genomes, compared to subgenomic regions, provided more precise estimates of the RSV sequence changes and revealed important patterns of RSV genomic variation and global movement. The novel sequencing method and the new RSV genomic sequences reported here expand our knowledge base for large-scale RSV epidemiological and transmission studies.IMPORTANCEThe new RSV genomic sequences and the novel sequencing method reported here provide important data for understanding RSV transmission and vaccine development. Given the complex interplay between RSV A and RSV B infections, the existence of local RSV B evolution is an important factor in vaccine deployment.

scholarly journals Estimation of influenza and respiratory syncytial virus hospitalizations using sentinel surveillance data—La Paz, Bolivia. 2012–2017

2019 ◽  
Vol 13 (5) ◽  
pp. 477-483 ◽  
Author(s):  
Dabeyva Chavez ◽  
Vicente Gonzales‐Armayo ◽  
Elvis Mendoza ◽  
Rakhee Palekar ◽  
Rosario Rivera ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Sentinel Surveillance ◽  
Surveillance Data ◽  
La Paz ◽  
Syncytial Virus

Use of Respiratory Syncytial Virus Surveillance Data to Optimize the Timing of Immunoprophylaxis

PEDIATRICS ◽  
2010 ◽  
Vol 126 (1) ◽  
pp. e116-e123 ◽  
Author(s):  
C. A. Panozzo ◽  
L. J. Stockman ◽  
A. T. Curns ◽  
L. J. Anderson
Keyword(s):  
Respiratory Syncytial Virus ◽  
Surveillance Data ◽  
Virus Surveillance ◽  
Syncytial Virus

scholarly journals Low levels of respiratory syncytial virus activity in Europe during the 2020/21 season: what can we expect in the coming summer and autumn/winter?

2021 ◽  
Vol 26 (29) ◽  
Author(s):  
Jojanneke van Summeren ◽  
Adam Meijer ◽  
Guðrún Aspelund ◽  
Jean Sebastien Casalegno ◽  
Guðrún Erna ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Winter Season ◽  
Surveillance Data ◽  
Critical Importance ◽  
Pharmacological Interventions ◽  
Small Children ◽  
Virus Activity ◽  
Low Levels ◽  
Syncytial Virus

Since the introduction of non-pharmacological interventions to control COVID-19, respiratory syncytial virus (RSV) activity in Europe has been limited. Surveillance data for 17 countries showed delayed RSV epidemics in France (≥ 12 w) and Iceland (≥ 4 w) during the 2020/21 season. RSV cases (predominantly small children) in France and Iceland were older compared with previous seasons. We hypothesise that future RSV epidemic(s) could start outside the usual autumn/winter season and be larger than expected. Year-round surveillance of RSV is of critical importance.

scholarly journals Molecular epidemiology of respiratory syncytial virus in The Gambia

1999 ◽  
Vol 122 (1) ◽  
pp. 155-160 ◽  
Author(s):  
P. A. CANE ◽  
M. WEBER ◽  
M. SANNEH ◽  
R. DACKOUR ◽  
C. R. PRINGLE ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Genetic Variability ◽  
G Protein ◽  
Protein Gene ◽  
The Gambia ◽  
The World ◽  
Rsv Infection ◽  
Syncytial Virus ◽  
The Uk ◽  
Developed World

Respiratory syncytial virus (RSV) infection in The Gambia occurs seasonally in association with the rainy season. This study examined the genetic variability of RSV isolates from four consecutive epidemics from 1993–6. Each epidemic was made up of a number of variants which were replaced in subsequent epidemics. Analysis of attachment (G) protein gene sequences showed that isolates were closely related to those observed in the rest of the world. However, many isolates from 1993 and 1994 were unlike other isolates observed in the developed world during this period and were more similar to isolates from 1984 in Europe. In addition, the most commonly observed genotype in the UK in the 1990s was not detected in The Gambia during this period.

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