Plasma Levels and Effect on Heart Rate and Blood Pressure of Metoprolol after Acute Oral Administration in 12 Geriatric Patients

2009 ◽  
Vol 200 (1-6) ◽  
pp. 397-402 ◽  
Author(s):  
P. Lundborg ◽  
B. Steen
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Oral Administration ◽  
Plasma Levels ◽  
Geriatric Patients

The Involvement of Platelets and the Coronary Vasculature in Collagen-Induced Sudden Death in Rabbits

1985 ◽  
Vol 53 (01) ◽  
pp. 070-074 ◽  
Author(s):  
G Mallarkey ◽  
G M Smith
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Platelet Count ◽  
Sudden Death ◽  
Myocardial Ischaemia ◽  
Plasma Levels ◽  
Sodium Citrate ◽  
Plasma Samples ◽  
Calcium Entry Blockers

SummaryThe mechanism of collagen-induced sudden death in rabbits was studied by measuring blood pressure (BP), heart rate, ECG, the continuous platelet count and the plasma levels of thromboxane B2 (TxB2) and 6-keto prostaglandin Fia (6-keto PGF1α). Death was preceded by myocardial ischaemia and a sharp fall in BP which occurred before any fall in platelet count was observed. The calcium entry blockers (CEBs), verapamil, nifedipine and PY 108-068 protected the rabbits from sudden death without any significant effect on the decrease in the platelet count or increase in plasma TxB2 levels. 6-keto PGF1α could not be detected in any plasma samples. Indomethacin and tri-sodium citrate also protected the rabbits but significantly reduced the fall in platelet count and plasma TxB2. In vitro studies on isolated aortae indicated that verapamil non-specifically inhibited vasoconstriction induced by KC1, adrenaline and U46619 (a thromboxane agonist). It is concluded that CEBs physiologically antagonize the vasoconstricting actions of platelet-derived substances and that it is coronary vasoconstriction that is primarily the cause of death.

scholarly journals Forensic assessment of clinical manifestations when taking ethanol with carbonation

2021 ◽  
pp. 27-39
Author(s):  
A.A. Martemyanova ◽  
◽  
A.L. Kochoyan ◽  
R.A. Kalyokin ◽  
A.M. Orlova ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Oral Administration ◽  
Alcohol Intoxication ◽  
Clinical Manifestations ◽  
Forensic Assessment ◽  
Maximum Heart Rate ◽  
Significant Difference ◽  
Pressure Indicators

The differences in clinical manifestations of oral administration of 40% ethanol (vodka) with carbonation compared with neat (non-carbonated) vodka were studied. It was found that when taking carbonated ethanol, both subjective and objective symptoms appear, which are absent when taking ethanol without carbonation. The symptoms of alcohol intoxication characteristic of ethanol, both with and without carbonation, persist longer when carbonated ethanol is ingested. The maximum heart rate values when taking ethanol with carbonation, recorded 4 hours after ingestion, were 18.4% higher relative to the baseline (the time of intake), and when taking ethanol without carbonation — by 9.6%. There was no significant difference in the change in blood pressure indicators when taking ethanol with and without carbonation.

Effect Of Novel PGEl Analogue (OP-1206) On The Platelet Functions

1981 ◽  
Author(s):  
T Kitani ◽  
M Nakagawa ◽  
Y Maeda ◽  
T Kavamura ◽  
M Watada ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Platelet Aggregation ◽  
Oral Administration ◽  
In Vitro Study ◽  
Platelet Adhesiveness ◽  
Vein Thrombosis ◽  
Vasodilating Activity ◽  
Platelet Functions

PGEl is one of prostaglandins which inhibit platelet functions and has vasodilating activity similar to PGI2. Newly developed PGEi analogue (OP-1206) was supplied for the clinical evaluations on oral administration. This research was performed to analyze the effect of orally administrated PGE1 analogue on platelet functions and to evaluate the usefulness on the thromboembolic disorders. Comparing with PGI2, this analogue demonstrated the similar inhibitory activity on the platelet aggregation in vitro study. Oral administration of OP-1206 on the patients with thromboembolic disorders showed the dose-dependent inhibition on platelet aggregation and adhesiveness. This activity continued for l80 min (max at 120 min). Daily oral administration (20μg and 30μg t.i.d.) was continued for two weeks and its effect on blood pressure, heart rate, ADP induced platelet aggregation, platelet adhesiveness and platelet c-AMP level were evaluated. Both of administration doses caused remarkable depression of platelet aggregation, increment of c-AMP level in the platelet and mild suppression on the platelet adhesiveness. Blood pressure was decreased, but heart rate remained unchanged. Clinical improvement of symptoms were observed in the patients with deep vein thrombosis or angina pectoris. These results emphasize the effectiveness and usefulness of this orally administrated PGE1 analogue against the prevention and treatment of thromboembolic disorders.

Plasma levels, heart rate, and blood pressure after intravenous, oral, and aerosol administration of reproterol in man

1988 ◽  
Vol 9 (3) ◽  
pp. 301-314 ◽  
Author(s):  
R. J. J. Hageman ◽  
R. A. De Zeeuw ◽  
J. E. Greving ◽  
J. J. Krann ◽  
G. H. Koëter
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Plasma Levels

Downregulation of growth hormone in postural orthostatic tachycardia syndrome: insights from the SYSTEMA cohort

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
M Johansson ◽  
J Schulte ◽  
F Ricci ◽  
M Persson ◽  
R Sutton ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Growth Hormone ◽  
Plasma Levels ◽  
Orthostatic Intolerance ◽  
Statistical Tests ◽  
Growth Hormone Level ◽  
Postural Orthostatic Tachycardia Syndrome ◽  
Funding Source ◽  
Significant Difference

Abstract Background Postural orthostatic tachycardia syndrome (POTS) is a variant of cardiovascular autonomic disorder occurring predominantly in young women. POTS is characterized by an excessive heart rate increase when assuming upright posture accompanied by symptoms of orthostatic intolerance. The pathophysiology of POTS has not been fully established and is believed to be multifactorial. Purpose We aimed to investigate the alterations in circulating growth hormone level in POTS. Methods We conducted an age-matched case-control study enrolling 42 patients with POTS (age 31±9 years; 36 women) verified by positive head-up tilt testing and cardiovascular autonomic tests, and 46 controls (32±9 years; 35 women) with negative active standing test and no history of syncope, orthostatic intolerance and endocrine disease. We measured plasma levels of growth hormone using a high-sensitivity chemiluminescence immunoassay in relation to presence of POTS diagnosis. All study participants completed the validated Orthostatic Hypotension Questionnaire (OHQ), consisting of two components: the symptoms assessment scale (OHSA) and daily activity scale (OHDAS) to evaluate the burden of symptoms. We applied standard statistical tests for group differences. Growth hormone values were log-transformed and standardized before the group comparison. Results POTS patients had significantly lower plasma levels of growth hormone (ng/mL) (median=0.53, IQR, 0.10–2.83 vs. median=2.33, IQR, 0.26–7.2, p=0.04) than controls. Levels of growth hormone were reversely related to OHDAS (p=0.049) among POTS patients. Supine heart rate was significantly higher in POTS patients (69.0±11.1 beats/min vs. 63.3±10.8 beats/min, p=0.02), as well as diastolic blood pressure (72.9±9.1 mmHg vs. 69.0±8.5 mmHg, p=0.04). We observed no significant difference in supine systolic blood pressure (116.6±13.3 mmHg vs. 115.2±10.0 mmHg, p=0.60). POTS patients had a significantly higher composite OHQ score than controls (60.0±18.6 vs. 4.2±7.5, p<0.001), as well as OHSA (36.2±10.0 vs. 3.6±6.4, p<0.001) and OHDAS (23.8±9.7 vs. 0.6±1.3, p<0.001). Conclusion(s) Our study shows that patients with POTS have significantly reduced plasma levels of circulating growth hormone. Lower growth hormone levels among POTS patients are associated with increased impairment of daily life activities. Further studies are necessary to confirm our findings in the independent populations and explain the mechanisms behind this alteration. Funding Acknowledgement Type of funding source: Foundation. Main funding source(s): Crafoord Foundation, Swedish Heart and Lung Foundation

scholarly journals Effects of single oral administration of captopril on blood pressure, heart rate and humoral factors in man.

1984 ◽  
Vol 15 (4) ◽  
pp. 497-506
Author(s):  
Masaru MINAMI ◽  
Fuminori HASHIMOTO ◽  
Ichiro TAKAMURA ◽  
Katsuhiro FUJITA ◽  
Hisakazu YASUDA ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Oral Administration ◽  
Humoral Factors ◽  
Single Oral Administration

Comparison of Metoprolol and Propranolol in Modification of Haemodynamic and Renin-Aldosterone Responses to Tilting in Humans

1976 ◽  
Vol 51 (s3) ◽  
pp. 533s-535s
Author(s):  
G. W. Viol ◽  
E. K. M. Smith ◽  
J. D. Fitzgerald
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Oral Administration ◽  
Plasma Renin Activity ◽  
Systolic Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Plasma Renin ◽  
Plasma Aldosterone ◽  
Normal Males ◽  
Supine Systolic Blood Pressure

1. Acute oral administration of metoprolol and propranolol to ten normal males resulted in equal reduction in heart rate both supine and after passive tilting to 60°. 2. Tilted systolic blood pressure was reduced by both agents but metoprolol alone reduced supine systolic blood pressure. 3. Tilted but not supine diastolic blood pressure was reduced by both agents. 4. Metoprolol and propranolol both reduced the rise in plasma renin activity induced by tilting. 5. No effect of tilting was observed on plasma aldosterone.

Sign in / Sign up

Export Citation Format

Share Document