scholarly journals Effects of single oral administration of captopril on blood pressure, heart rate and humoral factors in man.

1984 ◽  
Vol 15 (4) ◽  
pp. 497-506
Author(s):  
Masaru MINAMI ◽  
Fuminori HASHIMOTO ◽  
Ichiro TAKAMURA ◽  
Katsuhiro FUJITA ◽  
Hisakazu YASUDA ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Oral Administration ◽  
Humoral Factors ◽  
Single Oral Administration

scholarly journals Forensic assessment of clinical manifestations when taking ethanol with carbonation

2021 ◽  
pp. 27-39
Author(s):  
A.A. Martemyanova ◽  
◽  
A.L. Kochoyan ◽  
R.A. Kalyokin ◽  
A.M. Orlova ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Oral Administration ◽  
Alcohol Intoxication ◽  
Clinical Manifestations ◽  
Forensic Assessment ◽  
Maximum Heart Rate ◽  
Significant Difference ◽  
Pressure Indicators

The differences in clinical manifestations of oral administration of 40% ethanol (vodka) with carbonation compared with neat (non-carbonated) vodka were studied. It was found that when taking carbonated ethanol, both subjective and objective symptoms appear, which are absent when taking ethanol without carbonation. The symptoms of alcohol intoxication characteristic of ethanol, both with and without carbonation, persist longer when carbonated ethanol is ingested. The maximum heart rate values when taking ethanol with carbonation, recorded 4 hours after ingestion, were 18.4% higher relative to the baseline (the time of intake), and when taking ethanol without carbonation — by 9.6%. There was no significant difference in the change in blood pressure indicators when taking ethanol with and without carbonation.

Effect Of Novel PGEl Analogue (OP-1206) On The Platelet Functions

1981 ◽  
Author(s):  
T Kitani ◽  
M Nakagawa ◽  
Y Maeda ◽  
T Kavamura ◽  
M Watada ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Platelet Aggregation ◽  
Oral Administration ◽  
In Vitro Study ◽  
Platelet Adhesiveness ◽  
Vein Thrombosis ◽  
Vasodilating Activity ◽  
Platelet Functions

PGEl is one of prostaglandins which inhibit platelet functions and has vasodilating activity similar to PGI2. Newly developed PGEi analogue (OP-1206) was supplied for the clinical evaluations on oral administration. This research was performed to analyze the effect of orally administrated PGE1 analogue on platelet functions and to evaluate the usefulness on the thromboembolic disorders. Comparing with PGI2, this analogue demonstrated the similar inhibitory activity on the platelet aggregation in vitro study. Oral administration of OP-1206 on the patients with thromboembolic disorders showed the dose-dependent inhibition on platelet aggregation and adhesiveness. This activity continued for l80 min (max at 120 min). Daily oral administration (20μg and 30μg t.i.d.) was continued for two weeks and its effect on blood pressure, heart rate, ADP induced platelet aggregation, platelet adhesiveness and platelet c-AMP level were evaluated. Both of administration doses caused remarkable depression of platelet aggregation, increment of c-AMP level in the platelet and mild suppression on the platelet adhesiveness. Blood pressure was decreased, but heart rate remained unchanged. Clinical improvement of symptoms were observed in the patients with deep vein thrombosis or angina pectoris. These results emphasize the effectiveness and usefulness of this orally administrated PGE1 analogue against the prevention and treatment of thromboembolic disorders.

Comparison of Metoprolol and Propranolol in Modification of Haemodynamic and Renin-Aldosterone Responses to Tilting in Humans

1976 ◽  
Vol 51 (s3) ◽  
pp. 533s-535s
Author(s):  
G. W. Viol ◽  
E. K. M. Smith ◽  
J. D. Fitzgerald
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Oral Administration ◽  
Plasma Renin Activity ◽  
Systolic Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Plasma Renin ◽  
Plasma Aldosterone ◽  
Normal Males ◽  
Supine Systolic Blood Pressure

1. Acute oral administration of metoprolol and propranolol to ten normal males resulted in equal reduction in heart rate both supine and after passive tilting to 60°. 2. Tilted systolic blood pressure was reduced by both agents but metoprolol alone reduced supine systolic blood pressure. 3. Tilted but not supine diastolic blood pressure was reduced by both agents. 4. Metoprolol and propranolol both reduced the rise in plasma renin activity induced by tilting. 5. No effect of tilting was observed on plasma aldosterone.

EFFECT OF CONTINUED ORAL ADMINISTRATION OF DIETHYLSTILBESTROL ON BLOOD PRESSURE, HEART RATE AND RESPIRATION OF ALBINO RATS

Endocrinology ◽  
1943 ◽  
Vol 33 (3) ◽  
pp. 177-180
Author(s):  
CHARLES S. MATTHEWS ◽  
FREDERICK E. EMERY ◽  
PAUL L. WEYGANDT
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Oral Administration ◽  
Albino Rats
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