New Evidence That the Tyr-157 and Tyr-159 Residues of Staphylococcal Exfoliative Toxin B Are Essential for Its Toxicity

1998 ◽  
Vol 42 (12) ◽  
pp. 829-836 ◽  
Author(s):  
Susumu Sakurai ◽  
Hitoshi Suzuki ◽  
Shinobu Saito ◽  
Yasuhiko Konishi ◽  
Katsuhiko Machida ◽  
...  
Keyword(s):  
Toxin B ◽  
Exfoliative Toxin ◽  
New Evidence

scholarly journals Staphylococcal Exfoliative Toxin B Specifically Cleaves Desmoglein 1

2002 ◽  
Vol 118 (5) ◽  
pp. 845-850 ◽  
Author(s):  
Masayuki Amagai ◽  
Koji Nishifuji ◽  
Takayuki Yamaguchi ◽  
Yasushi Hanakawa ◽  
Motoyuki Sugai ◽  
...  
Keyword(s):  
Toxin B ◽  
Exfoliative Toxin

The Crystal Structure of Exfoliative Toxin B:  A Superantigen with Enzymatic Activity†,‡

Biochemistry ◽  
1999 ◽  
Vol 38 (32) ◽  
pp. 10239-10246 ◽  
Author(s):  
Gregory M. Vath ◽  
Cathleen A. Earhart ◽  
Dileep D. Monie ◽  
John J. Iandolo ◽  
Patrick M. Schlievert ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Enzymatic Activity ◽  
Toxin B ◽  
Exfoliative Toxin

scholarly journals A Case of Staphylococcal Scalded Skin Syndrome Caused by Exfoliative Toxin-B Producing MRSA

1996 ◽  
Vol 70 (2) ◽  
pp. 206-210 ◽  
Author(s):  
Shumpei YOKOTA ◽  
Tomoyuki IMAGAWA ◽  
Shigeki KATAKURA ◽  
Toshihiro MITSUDA ◽  
Kazuji ARAI
Keyword(s):  
Toxin B ◽  
Staphylococcal Scalded Skin Syndrome ◽  
Exfoliative Toxin

scholarly journals Identification of Genes Encoding Two-Component Lantibiotic Production in Staphylococcus aureus C55 and Other Phage Group II S. aureus Strains and Demonstration of an Association with the Exfoliative Toxin B Gene

1999 ◽  
Vol 67 (8) ◽  
pp. 4268-4271 ◽  
Author(s):  
Maduwe A. D. B. Navaratna ◽  
Hans-Georg Sahl ◽  
John R. Tagg
Keyword(s):  
Staphylococcus Aureus ◽  
Elevated Temperatures ◽  
Toxin B ◽  
Phage Group ◽  
Exfoliative Toxin ◽  
Two Component ◽  
Genes Encoding ◽  
Peptide System ◽  
Group Ii ◽  
Considerable Homology

ABSTRACT The production of exfoliative toxin B (ET-B), but not ET-A, was shown to be specifically associated with production of a highly conserved two-component lantibiotic peptide system in phage group IIStaphylococcus aureus. Two previously studied but incompletely characterized S. aureus bacteriocins, staphylococcins C55 and BacR1, were found to be members of this lantibiotic system, and considerable homology was also found with the two-component Lactococcus lactis bacteriocin, lacticin 3147. sacαA and sacβA, the structural genes of the lantibiotics staphylococcins C55α and C55β and two putative lantibiotic processing genes, sacM1 and sacT, were localized together with the ET-B structural gene to a single 32-kb plasmid in strain C55. Irreversible loss of both ET-B and two-component lantibiotic production occurs during laboratory passage of ET-B-positive S. aureus strains, particularly at elevated temperatures.

scholarly journals Genetic Determinants of Methicillin Resistance and Virulence among Staphylococcus aureus Isolates Recovered from Clinical and Surveillance Cultures in a Brazilian Teaching Hospital

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Marcus Vinicius Pimenta Rodrigues ◽  
Carlos Magno Castelo Branco Fortaleza ◽  
Camila Sena Martins Souza ◽  
Natalia Bibiana Teixeira ◽  
Maria de Lourdes Ribeiro de Souza da Cunha
Keyword(s):  
Staphylococcus Aureus ◽  
Teaching Hospital ◽  
Virulence Genes ◽  
Methicillin Resistance ◽  
Multivariable Analysis ◽  
Invasive Disease ◽  
Genetic Determinants ◽  
Toxin B ◽  
Exfoliative Toxin ◽  
Panton Valentine Leukocidin

Aims. To quantify the presence of SCCmec types and virulence genes among Staphylococcus aureus colonizing and infecting patients from a teaching hospital. Methods. We analyzed 225 and 84 S. aureus isolates recovered from surveillance and clinical cultures, respectively. Strains were studied for the presence and type of SCCmec, as well as for several virulence genes. Univariate and multivariable analysis were performed in order to identify predictors of invasiveness (defined as isolation from clinical cultures). Results. The presence of SCCmec types III (OR, 2.19, 95% CI, 1.08–4.45) and IV (OR, 5.28 95% CI, 1.35–20.63) and of genes coding for exfoliative toxin B (etb, OR, 6.38, 95% CI, 1.48–27.46) and Panton-Valentine leukocidin (pvl, OR, 2.38, 95% CI, 1.16–4.86) was independently associated with invasiveness. Conclusions. SCCmec types III and IV and virulence genes are associated with greater invasiveness of S. aureus. Patients colonized with methicillin-resistant S. aureus, as well as with strains harboring etb or pvl, may be prone to develop invasive disease. Infection-preventing strategies should be more intensively applied to this group.

Staphylococcal scalded skin syndrome caused by exfoliative toxin B-producing methicillin-resistant

1996 ◽  
Vol 155 (8) ◽  
pp. 722 ◽  
Author(s):  
S. Yokota ◽  
T. Imagawa ◽  
S. Katakura ◽  
T. Mitsuda ◽  
K. Arai
Keyword(s):  
Toxin B ◽  
Methicillin Resistant ◽  
Staphylococcal Scalded Skin Syndrome ◽  
Exfoliative Toxin

scholarly journals Complete Nucleotide Sequence of aStaphylococcus aureus Exfoliative Toxin B Plasmid and Identification of a Novel ADP-Ribosyltransferase, EDIN-C

2001 ◽  
Vol 69 (12) ◽  
pp. 7760-7771 ◽  
Author(s):  
Takayuki Yamaguchi ◽  
Tetsuya Hayashi ◽  
Hideto Takami ◽  
Makoto Ohnishi ◽  
Takahiro Murata ◽  
...  
Keyword(s):  
Nucleotide Sequence ◽  
Rho Gtpases ◽  
Complete Nucleotide Sequence ◽  
Sequence Similarity ◽  
Size Variation ◽  
Cadmium Resistance ◽  
Toxin B ◽  
Scanning Method ◽  
Exfoliative Toxin ◽  
Adp Ribosyltransferase

ABSTRACT The complete nucleotide sequence of pETB, a 38.2-kbStaphylococcus aureus plasmid encoding the exfoliative toxin B (ETB), was determined. A total of 50 open reading frames were identified on the plasmid genome and, among these, 32 showed sequence similarity to known proteins. pETB contains three copies of IS257, which divide the pETB genome into three regions: (i) a cadmium resistance operon-containing region, (ii) a lantibiotic production gene-containing region, and (iii) the remaining part where genes for plasmid replication and/or maintenance are dispersed. In the third region, genes of various kinds of functions are present among the replication- and maintenance-related genes. They include two virulence-related genes, the etb gene and a gene encoding a novel ADP-ribosyltransferase closely related to EDIN, which belongs to the C3 family of ADP-ribosyltransferases modifying Rho GTPases. They also include genes for a cell wall-anchoring surface protein and a phage resistance protein. Based on the determined sequence of pETB, the genome structures of etb-bearing plasmids (ETB plasmids) from various clinical isolates were analyzed by the PCR scanning method. The data indicate that, although the ETB plasmids are highly heterogeneous in genome size, the fundamental genome organization is well conserved. The size variation of the plasmid is mainly attributed to defined regions which may be hot spots for gene shuffling.

Staphylococcal scalded skin syndrome caused by exfoliative toxin B-producing methicillin-resistantStaphylococcus aureus

1996 ◽  
Vol 155 (8) ◽  
pp. 722-722
Author(s):  
S. Yokota ◽  
T. Imagawa ◽  
S. Katakura ◽  
T. Mitsuda ◽  
K. Arai
Keyword(s):  
Toxin B ◽  
Staphylococcal Scalded Skin Syndrome ◽  
Exfoliative Toxin
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