scholarly journals Mega Base Map of the Epidermal Growth Factor (EGF) Receptor Gene Flanking Regions and Structure of the Amplification Units in EGF Receptor-hyperproducing Squamous Carcinoma Cells

1988 ◽  
Vol 79 (11) ◽  
pp. 1174-1183 ◽  
Author(s):  
Kazuhiko Kawasaki ◽  
Jun Kudoh ◽  
Keiichi Omoto ◽  
Nobuyoshi Shimizu
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Egf Receptor ◽  
Receptor Gene ◽  
Squamous Carcinoma ◽  
Carcinoma Cells ◽  
Squamous Carcinoma Cells ◽  
Epidermal Growth ◽  
Flanking Regions

Targeted Drug Delivery Via Human Epidermal Growth Factor Receptor for Sustained Release of Allyl Isothiocyanate

2018 ◽  
Vol 18 (14) ◽  
pp. 1252-1260 ◽  
Author(s):  
David Encinas-Basurto ◽  
Josue Juarez ◽  
Miguel A. Valdez ◽  
Maria G. Burboa ◽  
Silvia Barbosa ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Egf Receptor ◽  
Growth Factor Receptor ◽  
Squamous Carcinoma ◽  
Allyl Isothiocyanate ◽  
A431 Cells ◽  
Squamous Carcinoma Cells ◽  
Epidermal Growth

In this study, allyl-isothiocyanate (AITC)-loaded Polylactic-Co-Glycolic Acid (PLGA) Nanoparticles (NPs) were prepared for targeting epithelial squamous carcinoma cells using a specific antibody targeting the Epidermal Growth Factor (EGF) receptor overexpressed on the cell membranes. AITC-loaded PLGA NPs showed more effective anticancer properties compared with free AITC, and their cytotoxicity was even more pronounced when the anti-EGFR antibody was covalently attached to the NPs surface. This targeting ability was additionally tested by co-culturing cervical HeLa cells, with very few EGFR on the membranes, and epithelial squamous carcinoma A431 cells, which largely overexpressed EFGR, being observed the specific localization of the antibody-functionalized AITC-loaded PLGA NPs solely in the latter types of cells, whereas non-functionalized NPs were distributed randomly in both cell types in much lesser extents. Thus, our findings support the development of drug delivery strategies that enhances the delivery of anti-cancer natural compounds to tumor tissue, in this case, by targeting specific tumor cell receptors with cell-specific ligands followed by tumor sensitization.

Inhibition of epidermal growth factor binding system by ionizing radiation in A431 human squamous carcinoma cells

1995 ◽  
Vol 89 (2) ◽  
pp. 153-159 ◽  
Author(s):  
Takenori Matsuo ◽  
Akira Ohtsuru ◽  
Masahiro Ito ◽  
Kenshi Komatsu ◽  
Yutaka Okumura ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Ionizing Radiation ◽  
Squamous Carcinoma ◽  
Carcinoma Cells ◽  
Factor Binding ◽  
Binding System ◽  
Squamous Carcinoma Cells ◽  
Epidermal Growth
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