Mutations in the erythrocyte chemokine receptor (Duffy) gene: the molecular basis of the Fya/Fybantigens and identification of a deletion in the Duffy gene of an apparently healthy individual with the Fy(a – b–) phenotype

The molecular basis of sarcoma remains poorly understood. However, recent studies have begun to uncover some of the molecular pathways involved in sarcomagenesis. The chemokine receptor CXCR4 has been implicated in sarcoma development and has been found to be a prognostic marker for poor clinical outcome. There is growing evidence that overexpression of CXCR4 plays a significant role in development of metastatic disease, especially in directing tumor cells towards the preferential sites of metastases in sarcoma, lung and bone. Although further investigation is necessary to validate these pathways, there is potential for clinical application, particularly in the use of pharmacologic inhibitors of CXCR4 as means of preventing sarcoma metastasis.

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Urine-albumin and creatinine ratio among apparently healthy individual in South Eastern, Nigeria

GSC Biological and Pharmaceutical Sciences ◽

10.30574/gscbps.2021.16.1.0185 ◽

2021 ◽

Vol 16 (1) ◽

pp. 105-114

Author(s):

Amos Dangana ◽

Ifeoma Miracle Okoronkwo ◽

Solomon Oloche Onoja ◽

Innocent Nwabueze Okonkwo ◽

Nonye Bibiana Egenti ◽

...

Keyword(s):

Healthy Individual ◽

Kinetic Method ◽

Pulse Height ◽

Calculated Data ◽

Enzyme Linked Immunosorbent Assay ◽

Creatinine Ratio ◽

Hypertensive Nephropathy ◽

Urine Albumin ◽

Significant Difference ◽

Apparently Healthy

Background: Albuminuria and Albumin-Creatinine Ratio (ACR) has been identified as early indices of cardiovascular diseases (CVD), Hypertension and are at great risk of hypertensive nephropathy, but this not so for the apparently healthy individuals. Objectives: This study was therefore carried out to evaluate and quantitate albuminuria and urine ACR among apparently healthy individual and to compare values with the hypertensive attending University of Nigeria Teaching Hospital, Ituku-Ozalla Enugu State. Materials and method: The study was carried out on eighty-nine (89) volunteers (50 tests and 39 controls) age 21-77 years between August and September 2019. A structured questionnaire was used to get vital information, anthropometric measurements were taken while blood and urine samples were collected and analyzed for serum creatinine (Scr), urine creatinine (UCr) and urine albumin using Jaffe modified kinetic method and Enzyme Linked Immunosorbent Assay (ELISA) method respectively. Body mass index (BMI) in Kg/m2, urine ACR in mg/mmol and estimated glomerular filtration rate (eGFR) using Chronic Disease Epidemiology Equation were calculated. Data were analyzed using student’s T-test and one-way Analysis of variance (ANOVA). Results: Generally, results showed that males have higher (p<0.05) height, Scr, eGFR, and UCr but lower (p<0.05) BMI) when compared with the females, but no significant difference (P>0.05) between systolic blood pressure (SBP), diastolic BP (DBP), pulse, weight, urine albumin and ACR. Also, the study revealed that the test subjects have higher SBP, DBP, weight, BMI, SCr, urine albumin, and ACR but lower (p<0.05) eGFR and UCr when compared with the control subjects, but no significant difference (P>0.05) between pulse and height. Furthermore, intra gender analysis of the results showed that males tests have higher SBP, DBP, weight, BMI and urine ACR but lower (p<0.05) eGFR and UCr when compared with male controls, but no significant difference (P>0.05) was observed for pulse, height, Scr and urine albumin. Finally, the results showed that female tests have higher (P<0.05) SBP, pulse, Scr, urine albumin and ACR but lower (p<0.05) eGFR when compared with the female controls Conclusion: Findings and results from this study suggest that the hypertensives stand a higher risk of kidney damage, consequently cardiovascular disease (CVD).

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The Molecular Basis of the Chemokine/Chemokine Receptor Interaction—Scope for Design of Chemokine Antagonists

Methods ◽

10.1006/meth.1996.0086 ◽

1996 ◽

Vol 10 (1) ◽

pp. 126-134 ◽

Cited By ~ 15

Author(s):

Timothy N.C. Wells ◽

Amanda E.I. Proudfoot ◽

Christine A. Power ◽

Manjula Lusti-Narasimhan ◽

Sami Alouani ◽

...

Keyword(s):

Chemokine Receptor ◽

Molecular Basis ◽

Receptor Interaction

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CCR7 and CCR9 together recruit hematopoietic progenitors to the adult thymus

Blood ◽

10.1182/blood-2009-08-237784 ◽

2010 ◽

Vol 115 (10) ◽

pp. 1897-1905 ◽

Cited By ~ 151

Author(s):

Daniel A. Zlotoff ◽

Arivazhagan Sambandam ◽

Theodore D. Logan ◽

J. Jeremiah Bell ◽

Benjamin A. Schwarz ◽

...

Keyword(s):

Bone Marrow ◽

Chemokine Receptor ◽

Molecular Basis ◽

Critical Role ◽

Adult Life ◽

Hematopoietic Progenitors ◽

Double Knockout ◽

Cellular Identity ◽

Adult Thymus

Abstract T lymphopoiesis requires settling of the thymus by bone marrow–derived precursors throughout adult life. Progenitor entry into the thymus is selective, but the molecular basis of this selectivity is incompletely understood. The chemokine receptor CCR9 has been demonstrated to be important in this process. However, progenitors lacking CCR9 can still enter the thymus, suggesting a role for additional molecules. Here we report that the chemokine receptor CCR7 is also required for efficient thymic settling. CCR7 is selectively expressed on bone marrow progenitors previously shown to have the capacity to settle the thymus, and CCR7−/− progenitors are defective in settling the thymus. We further demonstrate that CCR7 sustains thymic settling in the absence of CCR9. Mice deficient for both CCR7 and CCR9 have severe reductions in the number of early thymic progenitors, and in competitive assays CCR7−/−CCR9−/− double knockout progenitors are almost completely restricted from thymic settling. However, these mice possess near-normal thymic cellularity. Compensatory expansion of intrathymic populations can account for at least a part of this recovery. Together our results illustrate the critical role of chemokine receptor signaling in thymic settling and help to clarify the cellular identity of the physiologic thymic settling progenitors.

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