DOPAMINERGIC CONTROL OF GONADOTROPHIN SECRETION IN NORMAL WOMEN AND IN PATIENTS WITH PATHOLOGICAL HYPERPROLACTINAEMIA

Abstract. For determination of the site of action of oestrogen (E) during the negative and positive feedback phases of gonadotrophin secretions, studies were made on the pituitary response to a small amount of LRH and the pulsatility of gonadotrophins after E administration in normal cycling women in the mid-follicular phase. The pituitary responses to an iv bolus of 2.5 μg of synthetic LRH were evaluated by measuring serum LH and FSH 2 h before and 8 h after administration of 20 mg of conjugated E (Premarin). In the next cycle, the pituitary responses to a same dose of LRH were also observed 2 h before and 56 h after E injection. The mean levels of serum LH and FSH and the peak responses to LRH were significantly (P < 0.05) decreased 8 h after E injection, but were significantly (P < 0.05) increased 56 h after E administration. In the third cycle, the pulsatility of gonadotrophins was evaluated by measuring serum LH and FSH every 15 min for 180 min before and 8 h and 56 h after E injection. The pulse frequencies of gonadotrophins were not significantly different before and 8 h and 56 h after E injection. The amplitudes of pulses 56 h after Premarin injection were significantly higher than those before the injection. These findings suggest that the negative and positive feedback effects of E on gonadotrophin secretion may be caused, in part, by its direct action on the pituitary response to LRH.

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URINARY GONADOTROPHINS AND LUTEINIZING HORMONE-RELEASING HORMONE (LH-RH) LIKE IMMUNOREACTIVITY DURING THREE NORMAL REPRODUCTIVE CYCLES

Acta Endocrinologica ◽

10.1530/acta.0.0860015 ◽

1977 ◽

Vol 86 (1) ◽

pp. 15-24 ◽

Cited By ~ 3

Author(s):

J. P. Bourguignon ◽

P. Franchimont

Keyword(s):

Luteinizing Hormone ◽

Physicochemical Properties ◽

Reproductive Cycle ◽

Luteal Phase ◽

Subsequent Increase ◽

Luteinizing Hormone Releasing Hormone ◽

Gonadotrophin Secretion ◽

Normal Women ◽

Reproductive Cycles ◽

Lh Rh

ABSTRACT Highly specific and sensitive radioimmunological methods were applied to determine the levels of LH-RH like immunoreactivity in urine previously extracted by spherosil and methanol, and to assay the gonadotrophins, after extraction with acetone. The endogenous urinary LH-RH like immunoreactivity material was identified by chromatography on Sephadex G25, as having physicochemical properties similar to those of the hormone found in unextracted urine after iv injection of synthetic LH-RH, but different from those of the synthetic decapeptide. The LH-RH like immunoreactivity and the gonadotrophins were assayed in daily collected urine during the reproductive cycle of 3 normal women. A midcycle peak of both FSH and LH was found in each subject. No increases of LH-RH like immunoreactivity were found before or concomittant with the gonadotrophins surge. But peaks of urinary LH-RH like immunoreactivity were observed during the luteal phase, without subsequent increase of gonadotrophin secretion.

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Scanning and Transmission Electron Microscopy of the Endometrium in Women with Ovarian Dysgenesis (Turner'S Syndrome)

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100090725 ◽

1976 ◽

Vol 34 ◽

pp. 148-149

Author(s):

A. González-Angulo ◽

S. Armendares-Sagrera ◽

I. Ruíz de Chávez ◽

H. Marquez-Monter ◽

R. Aznar

Keyword(s):

Surface Epithelium ◽

Secretory Cells ◽

Turner's Syndrome ◽

Ciliated Cells ◽

Turner’S Syndrome ◽

Exogenous Hormone ◽

Ovarian Dysgenesis ◽

Transmission Electron ◽

Normal Women ◽

Microscopy Examination

It is a well documented fact that endometrial hyperplasia and adenocarcinoma may develop in women with Turner's syndrome who had received unopposed estrogen treatment (1), as well as in normal women under contraceptive medication with the sequential regime (2). The purpose of the present study was to characterize the possible changes in surface and glandular epithelium in these women who were treated with a sequential regime for a period of between three and eight years. The aim was to find organelle modifications which may lead to the understanding of the biology of an endometrium under exogenous hormone stimulation. Light microscopy examination of endometrial biopsies of nine patients disclosed a proliferative pattern; in two of these, there was focal hyperplasia. With the scanning electron microscope the surface epithelium in all biopsies showed secretory cells with microvilli alternating with non secretory ciliated cells. Regardless of the day of the cycle all biopsies disclosed a large number of secretory cells rich in microvilli (fig.l) with long and slender projections some of which were branching (fig. 2).

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Study of the Attachment Models in Prostitute Women and Normal Women in Iran

PsycEXTRA Dataset ◽

10.1037/e650892012-001 ◽

2012 ◽

Author(s):

Masoud Aref Nazari ◽

Mona Sarshar

Keyword(s):

Normal Women

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Platelet Adhesiveness in Symptomatic Women Taking Oral Contraceptives

Thrombosis and Haemostasis ◽

10.1055/s-0038-1653695 ◽

1971 ◽

Vol 26 (03) ◽

pp. 426-430 ◽

Cited By ~ 3

Author(s):

T. F Zuck ◽

J. J Bergin ◽

Jane M. Raymond ◽

W. R Dwyre ◽

D. G Corby

Keyword(s):

Oral Contraceptives ◽

Platelet Adhesiveness ◽

Combined Oral Contraceptives ◽

Increased Risk ◽

Normal Women ◽

Asymptomatic Women

SummaryPlatelet adhesiveness to glass was determined in several groups of women. Increases were found in women developing thrombovascular symptoms while taking combined oral contraceptives, compared to both normal women and asymptomatic users of oral contraceptives. Despite this increase, overlap of the groups did not permit discrimination between symptomatic and asymptomatic women. However, it is possible, that in concert with other coagulation changes, platelet adhesiveness to glass may prove adjunctive in defining women at increased risk of developing thrombovascular symptoms while taking oral contraceptives, and further define the mechanism of the increased risk.

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Decreased Levels of Histidine-Rich Glycoprotein (HRG) and Increased Levels of Free Plasminogen in Women on Oral Contraceptives Low in Estrogen

Thrombosis and Haemostasis ◽

10.1055/s-0038-1657281 ◽

1982 ◽

Vol 48 (03) ◽

pp. 283-285 ◽

Cited By ~ 28

Author(s):

Jørgen Jespersen ◽

Cornelis Kluft

Keyword(s):

Oral Contraceptives ◽

Ethinyl Estradiol ◽

Relative Increase ◽

Normal Group ◽

Plasma Samples ◽

Normal Women ◽

Made In

SummaryDeterminations by immunologic methods of histidine-rich glycoprotein (HRG) and plasminogen, were made in plasma samples collected during one normal or hormone induced cycle in 15 young, normal women and in 11 women using oral contraceptives with 30 μg ethinyl estradiol and 150 μg levo-norgestrel. The hormone group showed an increase in plasminogen level to about 150% of normal, while the concentration of HRG was decreased to about 75% of normal. This resulted in a considerable relative increase in the concentration of free plasminogen in the hormone group (calculated from the equilibrium: HRG·plasminogen ⇌ HRG + plasminogen, using KD = 1.0 μM), representing a doubling of that in the normal group. Hence, more plasminogen is available for binding to fibrin and activation in the hormone group.

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OESTROGENIC, ANDROGENIC AND GONADOTROPHIC SUBSTANCES IN THE URINE OF NORMAL WOMEN

Acta Endocrinologica ◽

10.1530/acta.0.0010038 ◽

1948 ◽

Vol 1 (1) ◽

pp. 38-60 ◽

Cited By ~ 18

Author(s):

K. PEDERSEN-BJERGAARD ◽

M. TØNNESEN

Keyword(s):

Normal Women

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POSTPONEMENT OF MENSES, SUPPRESSION OF URINARY GONADOTROPHIN, 17-KGS AND 17-KS IN NORMAL WOMEN TREATED WITH A MEGESTROL-ACETATE/MESTRANOL COMBINATION (DELPREGNIN) FROM DAY 20 OF THE CYCLE

Acta Endocrinologica ◽

10.1530/acta.0.049s099 ◽

1965 ◽

Vol 49 (3_Suppl) ◽

pp. S99 ◽

Cited By ~ 4

Author(s):

E. Østergaard ◽

J. Arends ◽

C. Hamburger ◽

S. G. Johnsen

Keyword(s):

Megestrol Acetate ◽

Normal Women

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HYPOTHALAMIC SEXUAL PRECOCITY IN FEMALE RATS OPERATED SHORTLY AFTER BIRTH

Acta Endocrinologica ◽

10.1530/acta.0.0410301 ◽

1962 ◽

Vol 41 (2) ◽

pp. 301-313 ◽

Cited By ~ 11

Author(s):

S. Horowitz ◽

J. J. Van der Werff ten Bosch

Keyword(s):

Anterior Commissure ◽

Anterior Hypothalamus ◽

Female Rats ◽

Vaginal Opening ◽

Sexual Precocity ◽

Paraventricular Nuclei ◽

Gonadotrophin Secretion ◽

Electrolytic Lesions

ABSTRACT Electrolytic lesions were placed in the anterior hypothalamus of 3–4 day-old female rats; vaginal opening was hastened in comparison with blank-operated littermates in 12 of 17 rats bearing a lesion in the basal supra-and post-chiasmatic area. In the animals with the earliest vaginal opening, lesions reached upward towards the region of the anterior commissure and the paraventricular nuclei. The degree of advancement of puberty in rats operated at the age of 3 or 4 days was similar to that caused by lesions made at 10, 14 or 15 days. This finding suggests that the effect of a lesion upon gonadotrophin secretion does not begin to take place until after the age of at least two weeks.

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