Response of sex hormone binding globulin and insulin-like growth factor binding protein-1 to an oral glucose tolerance test in obese women with polycystic ovary syndrome before and after calorie restriction

1993 ◽  
Vol 39 (3) ◽  
pp. 363-367 ◽  
Author(s):  
D. Hamilton-Fairley ◽  
D. Kiddy ◽  
V. Anyaoku ◽  
R. Koistinen ◽  
M. Seppälä ◽  
...  
Keyword(s):  
Glucose Tolerance Test ◽  
Polycystic Ovary ◽  
Tolerance Test ◽  
Sex Hormone Binding Globulin ◽  
Oral Glucose ◽  
Obese Women ◽  
Oral Glucose Tolerance ◽  
Hormone Binding ◽  
Ovary Syndrome ◽  
Before And After

Persistence of hyperinsulinemia in polycystic ovary syndrome after ovarian suppression by gonadotropin-releasing hormone agonist

1992 ◽  
Vol 126 (2) ◽  
pp. 132-136 ◽  
Author(s):  
Per Olav Dale ◽  
Tom Tanbo ◽  
Ole Djøseland ◽  
Jak Jervell ◽  
Thomas Åbyholm
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Glucose Tolerance ◽  
Glucose Tolerance Test ◽  
Polycystic Ovary ◽  
Tolerance Test ◽  
Oral Glucose ◽  
Obese Women ◽  
Oral Glucose Tolerance ◽  
Ovary Syndrome ◽  
Gonadotropin Releasing Hormone Agonist

To investigate the effect of long-term androgen suppression on insulin sensitivity, obese and non-obese women with the polycystic ovary syndrome and obese and non-obese ovulatory women were given an oral glucose tolerance test before and after treatment with a gonadotropin-releasing hormone agonist. The women with polycystic ovary syndrome showed higher basal luteinizing hormone and androgen levels than the ovulatory women. All women with the polycystic ovary syndrome responded non-diabetically to the glucose tolerance test. However, compared with controls, the obese women with the polycystic ovary syndrome showed a hyperinsulinemic response to the glucose tolerance test, indicating insulin resistance. During the 3-h glucose tolerance test there was no concomitant change in androgen levels in the hyperinsulinemic women with the polycystic ovary syndrome. The insulin response to an oral glucose tolerance test remained unchanged in all women, although a hypogonadotropic hypogonadal state was maintained for several weeks. This study therefore suggests that endogenous androgens do not play a role in sustaining insulin resistance in women with the polycystic ovary syndrome.

scholarly journals The Estimated Adolescents�Carbohydrate Metabolism and Insulin Resistance in PCOS

2019 ◽  
Vol 70 (6) ◽  
pp. 2256-2260
Author(s):  
Mariana Stuparu Cretu ◽  
Camelia Busila ◽  
Liliana Caraman ◽  
Gabriela Balan ◽  
Alina Mihaela Calin
Keyword(s):  
Metabolic Disorders ◽  
Glucose Tolerance Test ◽  
Polycystic Ovary ◽  
Clinical Signs ◽  
Tolerance Test ◽  
Therapeutic Interventions ◽  
Oral Glucose ◽  
Risk Markers ◽  
Oral Glucose Tolerance ◽  
Ovary Syndrome

The Polycystic Ovary Syndrome (PCOS) represents a recognised entity within the female medical conditions today. The multidisciplinary aspects refer to various and variable symptomatology, which mainly associates the reproductive problems with clinical signs of hyper-androgyny and metabolic disorders, frequently associated with obesity. The present study demonstrates the existence of some carbohydrate metabolic anomalies in adolescents diagnosed with PCOS which had remained asymptomatic and undiagnosed prior to the analysis. It is thus suggested that metabolic testing is necessary for adolescents diagnosed with PCOS, even if they are neither overweight nor part of the definition criteria. It is important for the therapeutic interventions to analyse the DM2 intermediary risk markers, as the oral glucose tolerance test (OGTT) repeated 3 hours after glucose powder dose ingestion is informative of the persistent hyperglycaemia and the decrease in pancreatic function.

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