Bone geometry and volumetric bone mineral density in girls with Turner syndrome of different pubertal stages

Objective.To investigate the effect of rheumatoid arthritis (RA) on volumetric bone mineral density (vBMD) and bone geometry in postmenopausal women treated with bisphosphonates.Methods.Fifty-three postmenopausal women with RA and 87 control subjects, comparable in terms of age, body mass index, and years since menopause, underwent peripheral quantitative computed tomography (pQCT) of the nondominant tibia.Results.At 4% (trabecular site), trabecular bone mineral content (BMC) and vBMD (p < 0.001) were lower in the RA group, while trabecular area was comparable. At 38% (cortical site), cortical BMC (p < 0.01), area (p < 0.05), and thickness (p < 0.001) were lower in the RA group, whereas vBMD was comparable. Endosteal circumference was higher (p < 0.05), whereas periosteal circumference was comparable, indicating cancellization of cortical bone. In the RA group, muscle area was lower (p < 0.001), while at 14% polar stress strength index was significantly lower (p < 0.01) in patients with RA, indicating impairment of bone mechanical properties.Conclusion.RA is associated with negative effects on both cortical and cancellous bone in postmenopausal women treated with bisphosphonates. Cortical geometric properties are also adversely affected mainly by increased endosteal circumference, whereas trabecular geometric properties are generally preserved.

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A 6-Year Follow-Up of Fracture Incidence and Volumetric Bone Mineral Density Development in Girls With Turner Syndrome

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2017-02381 ◽

2017 ◽

Vol 103 (3) ◽

pp. 1188-1197 ◽

Cited By ~ 13

Author(s):

Ondrej Soucek ◽

Eckhard Schönau ◽

Jan Lebl ◽

Johannes Willnecker ◽

Zdenek Hlavka ◽

...

Keyword(s):

Bone Mineral Density ◽

Turner Syndrome ◽

Bone Strength ◽

Bone Mineral ◽

Osteoporotic Fractures ◽

Volumetric Bone Mineral Density ◽

Fracture Rate ◽

Mineral Density ◽

Bone Parameters ◽

Normal Bone

Abstract Context Patients with Turner syndrome (TS) are at risk for osteoporotic fractures. Objective The aims of this study were to assess the incidence of clinically important fractures in girls with TS and prospectively describe the development of volumetric bone mineral density (BMD). Design Peripheral quantitative computerized tomography (pQCT) of the radius every other year over the 6 years of observation. Setting Government-funded university referral center. Participants Thirty-two girls with TS, aged 6 to 16 years, were included in the analyses. Fracture incidence was compared with the data in the general population. Bone density and strength were compared with data from 185 healthy girls. Outcomes The main clinical outcome was the fracture occurrence. The secondary outcomes were the changes in Z-scores of the bone parameters. Results Three girls with TS sustained four fractures during 6 years of observation. The fracture rate in TS was not substantially higher than the downward-biased fracture-rate estimate from age-matched, healthy controls (P = 0.48). Whereas the trabecular BMD Z-score decreased with age (β estimate −0.21 ± 0.04, P < 0.001), total bone cross-sectional area correspondingly increased (+0.16 ± 0.04, P < 0.001), which led to normal bone strength. A positive history of incident fractures was not significantly associated with any of the pQCT-derived bone parameters. Conclusions Current pediatric TS patients that are treated with growth hormone and estrogens are not at risk for osteoporotic fractures. Low BMD in TS may be counterweighted by enlarged bone radius, which leads to normal bone strength at the appendicular skeleton.

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Relationships between bone geometry, volumetric bone mineral density and bone microarchitecture of the distal radius and tibia with alcohol consumption

Bone ◽

10.1016/j.bone.2015.05.002 ◽

2015 ◽

Vol 78 ◽

pp. 122-129 ◽

Cited By ~ 15

Author(s):

Julien Paccou ◽

Mark Hiley Edwards ◽

Kate Ward ◽

Karen Jameson ◽

Rebecca Moon ◽

...

Keyword(s):

Bone Mineral Density ◽

Alcohol Consumption ◽

Distal Radius ◽

Bone Mineral ◽

Bone Microarchitecture ◽

Bone Geometry ◽

Volumetric Bone Mineral Density ◽

Mineral Density

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Effect of Rhythmic Gymnastics on Volumetric Bone Mineral Density and Bone Geometry in Premenarcheal Female Athletes and Controls

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2009-2382 ◽

2010 ◽

Vol 95 (6) ◽

pp. 2755-2762 ◽

Cited By ~ 29

Author(s):

S. Tournis ◽

E. Michopoulou ◽

I. G. Fatouros ◽

I. Paspati ◽

M. Michalopoulou ◽

...

Keyword(s):

Bone Mineral Density ◽

Bone Mineral ◽

Quantitative Computed Tomography ◽

Bone Geometry ◽

Bone Age ◽

Peripheral Quantitative Computed Tomography ◽

Volumetric Bone Mineral Density ◽

Mineral Density ◽

Muscle Area ◽

Positive Effects

Abstract Context and Objective: Weight-bearing exercise during growth exerts positive effects on the skeleton. Our objective was to test the hypothesis that long-term elite rhythmic gymnastics exerts positive effects on volumetric bone mineral density and geometry and to determine whether exercise-induced bone adaptation is associated with increased periosteal bone formation or medullary contraction using tibial peripheral quantitative computed tomography and bone turnover markers. Design and Setting: We conducted a cross-sectional study at a tertiary center. Subjects: We studied 26 elite premenarcheal female rhythmic gymnasts (RG) and 23 female controls, aged 9–13 yr. Main Outcome Measures: We measured bone age, volumetric bone mineral density, bone mineral content (BMC), cortical thickness, cortical and trabecular area, and polar stress strength index (SSIp) by peripheral quantitative computed tomography of the left tibia proximal to the distal metaphysis (trabecular) at 14, 38 (cortical), and 66% (muscle mass) from the distal end and bone turnover markers. Results: The two groups were comparable according to height and chronological and bone age. After weight adjustment, cortical BMC, area, and thickness at 38% were significantly higher in RG (P < 0.005–0.001). Periosteal circumference, SSIp, and muscle area were higher in RG (P < 0.01–0.001). Muscle area was significantly associated with cortical BMC, area, and SSIp, whereas years of training showed positive association with cortical BMC, area, and thickness independent of chronological age. Conclusions: RG in premenarcheal girls may induce positive adaptations on the skeleton, especially in cortical bone. Increased duration of exercise is associated with a positive response of bone geometry.

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