A functional polymorphism in pre‐microRNA‐196a‐2 contributes to the susceptibility of hepatocellular carcinoma in a Turkish population: a case–control study

2010 ◽  
Vol 18 (7) ◽  
Author(s):  
H. Akkız ◽  
S. Bayram ◽  
A. Bekar ◽  
E. Akgöllü ◽  
Y. Ülger
Keyword(s):  
Hepatocellular Carcinoma ◽  
Case Control Study ◽  
Turkish Population ◽  
Case Control ◽  
Functional Polymorphism ◽  
Control Study

No association of pre-microRNA-146a rs2910164 polymorphism and risk of hepatocellular carcinoma development in Turkish population: A case-control study

Gene ◽  
2011 ◽  
Vol 486 (1-2) ◽  
pp. 104-109 ◽  
Author(s):  
Hikmet Akkız ◽  
Süleyman Bayram ◽  
Aynur Bekar ◽  
Ersin Akgöllü ◽  
Oğuz Üsküdar ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Case Control Study ◽  
Turkish Population ◽  
Case Control ◽  
Control Study

G-308A TNF-α polymorphism is associated with an increased risk of hepatocellular carcinoma in the Turkish population: Case-control study

2009 ◽  
Vol 33 (3-4) ◽  
pp. 261-264 ◽  
Author(s):  
Hikmet Akkız ◽  
Süleyman Bayram ◽  
Aynur Bekar ◽  
Burhan Özdil ◽  
Ersin Akgöllü ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Case Control Study ◽  
Turkish Population ◽  
Case Control ◽  
Increased Risk ◽  
Tnf Α ◽  
Control Study

scholarly journals Hepatitis B virus pre-S deletion mutations are a risk factor for hepatocellular carcinoma: a matched nested case–control study

2008 ◽  
Vol 89 (11) ◽  
pp. 2882-2890 ◽  
Author(s):  
Zhong-Liao Fang ◽  
Caroline A. Sabin ◽  
Bai-Qing Dong ◽  
Shao-Chao Wei ◽  
Qin-Yan Chen ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Risk Factor ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Case Control Study ◽  
Case Control ◽  
Deletion Mutations ◽  
B Virus ◽  
Nested Case Control ◽  
Control Study

A matched nested case–control study of 33 paired cases and controls was conducted, based on a study cohort in Long An county, Guangxi, China, to determine whether infection with hepatitis B virus (HBV) with pre-S deletions is independently associated with the development of hepatocellular carcinoma (HCC), without the confounding effects of basal core promoter (BCP) double mutations. The prevalence of pre-S deletions was significantly higher in HCC (45.5 %, 15 of 33) than the controls (18.2 %, 6 of 33) (P<0.01), under the control of the influence of BCP double mutations. Most of the pre-S deletions occurred in, or involved, the 5′ half of the pre-S2 region and the difference between HCC (93.3 %, 14 of 15) and controls (66.7 %, four of six) was significant for this region (P=0.015). There was no significant difference in pre-S deletions between the BCP mutant group and BCP wild-type group (P>0.05), nor was the prevalence of pre-S deletions significantly different between genotypes B and C (P>0.1). These results suggest that pre-S deletions constitute an independent risk factor for HCC and their emergence and effect are independent of BCP mutations. The 5′ terminus of pre-S2 is the favoured site for the deletion mutations, especially in HCC cases. Further prospective studies are required to confirm the role of these mutations in the development of HCC.

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