scholarly journals Heat shock protein 90 and its co-chaperone protein phosphatase 5 interact with distinct regions of the tomato I-2 disease resistance protein

2005 ◽  
Vol 43 (2) ◽  
pp. 284-298 ◽  
Author(s):  
Sergio De La Fuente Bentem van ◽  
Jack H. Vossen ◽  
Klaas Jan Vries ◽  
Saskia Wees ◽  
Wladimir I.L. Tameling ◽  
...  
Keyword(s):  
Disease Resistance ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Protein Phosphatase ◽  
Heat Shock Protein 90 ◽  
Protein Phosphatase 5 ◽  
Chaperone Protein ◽  
Disease Resistance Protein ◽  
Resistance Protein

scholarly journals Heat shock protein 90 inhibition: rationale and clinical potential

2012 ◽  
Vol 4 (4) ◽  
pp. 211-218 ◽  
Author(s):  
Robert B. Den ◽  
Bo Lu
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Molecular Chaperone ◽  
Three Dimensional ◽  
Heat Shock Protein 90 ◽  
Hsp90 Inhibition ◽  
Cellular Survival ◽  
Chaperone Protein ◽  
Cellular Stresses ◽  
Clinical Potential

Heat shock protein 90 (HSP90) is a molecular chaperone protein essential for cellular survival. Functionally, HSPs promote proper protein folding, prevent misfolding, and restore three-dimensional protein structure which is critical following toxic cellular stresses. Recently, targeting HSP90 pharmacologically has gained traction in cancer therapy. Oncogenic cells depend on their ability to withstand endogenous (anoxia, nutrient deprivation, pH changes, and deranged signaling pathways) and exogenous (chemotherapy and radiation therapy) stressors for survival. Pharmacological inhibition of HSP90 destabilizes proteins and leads to degradation through the proteasome. This article will review the utility of HSP90 inhibition, as well as the current adoption in clinical trials and practice.

Glycyrrhizin effects rat hepatocytes via the reduction of heat shock protein 90 expression

2001 ◽  
Vol 120 (5) ◽  
pp. A357-A357
Author(s):  
T YOH ◽  
T NAKASHIMA ◽  
Y SUMIDA ◽  
Y KAKISAKA ◽  
H ISHIKAWA ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 90 ◽  
Rat Hepatocytes
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