scholarly journals Control of human African trypanosomiasis: trap and odour preference of tsetse flies (Glossina morsitans submorsitans) in the upper Didessa river valley of Ethiopia

2004 ◽  
Vol 9 (6) ◽  
pp. 710-714 ◽  
Author(s):  
H. Belete ◽  
G. Tikubet ◽  
B. Petros ◽  
W. A. Oyibo ◽  
I. N. Otigbuo
Keyword(s):  
Human African Trypanosomiasis ◽  
River Valley ◽  
Tsetse Flies ◽  
African Trypanosomiasis ◽  
Glossina Morsitans ◽  
Glossina Morsitans Submorsitans

Human African trypanosomiasis

2010 ◽  
pp. 1119-1127
Author(s):  
August Stich
Keyword(s):  
West Africa ◽  
East Africa ◽  
Trypanosoma Brucei ◽  
Human African Trypanosomiasis ◽  
Protozoan Parasite ◽  
Sleeping Sickness ◽  
Tsetse Flies ◽  
African Trypanosomiasis ◽  
Tropical Africa

Human African trypanosomiasis (HAT, sleeping sickness) is caused by two subspecies of the protozoan parasite Trypanosoma brucei: T. b. rhodesiense is prevalent in East Africa among many wild and domestic mammals; T. b. gambiense causes an anthroponosis in Central and West Africa. The disease is restricted to tropical Africa where it is transmitted by the bite of infected tsetse flies (...

Human African trypanosomiasis

2020 ◽  
pp. 1451-1459
Author(s):  
Reto Brun ◽  
Johannes Blum
Keyword(s):  
Trypanosoma Brucei ◽  
Human African Trypanosomiasis ◽  
Specific Treatment ◽  
Protozoan Parasite ◽  
Control Measures ◽  
Tsetse Flies ◽  
African Trypanosomiasis ◽  
Control Programmes ◽  
The 1960S ◽  
Stage 1

Human African trypanosomiasis (sleeping sickness) is caused by subspecies of the protozoan parasite Trypanosoma brucei. The disease is restricted to tropical Africa where it is transmitted by the bite of infected tsetse flies (Glossina spp.). Control programmes in the 1960s were very effective, but subsequent relaxation of control measures led to recurrence of epidemic proportions in the 1980s and 1990s. Control is now being regained. Untreated human African trypanosomiasis is almost invariably fatal. Specific treatment depends on the trypanosome subspecies and the stage of the disease. Drugs used for stage 1 include pentamidine and suramin, and for stage 2 include melarsoprol, eflornithine, and nifurtimox, but regimens are not standardized, and treatment is difficult and dangerous; all of the drugs used have many side effects, some potentially lethal.

scholarly journals PO 8421 LITERATURE REVIEW OF BIOMARKERS FOR HUMAN AFRICAN TRYPANOSOMIASIS POST-TREATMENT FOLLOW-UP

2019 ◽  
Vol 4 (Suppl 3) ◽  
pp. A35.3-A36
Author(s):  
Lukusa Ngay ◽  
Veerle Lejon ◽  
Mumba Ngoyi
Keyword(s):  
Treatment Failure ◽  
Human African Trypanosomiasis ◽  
Post Treatment ◽  
Immunoglobulin M ◽  
Sub Saharan Africa ◽  
Tsetse Flies ◽  
African Trypanosomiasis ◽  
Cell Counts ◽  
Specificity And Sensitivity

IntroductionHuman African trypanosomiasis (HAT) is caused by Trypanosoma brucei gambiense and rhodesiense and is transmitted to humans by tsetse flies in sub-Saharan Africa. To detect cure or treatment failure, patients are followed up after treatment integrating the use of biomarkers in blood or cerebrospinal fluid (CSF).MethodsA systematic review of the literature according to the PRISMA Statement for Reporting Systematic Reviews was done, focusing on biological markers for HAT post-treatment follow-up. Articles were retrieved from PubMed (https://www.ncbi.nlm.nih.gov/pubmed/) by using keywords: Human African Trypanosomiasis, Biomarkers, Follow up, Post treatment.ResultsA panel of biomarkers is used to detect relapses or to confirm recovery. For post-treatment follow-up, an examination of the CSF is performed. White blood cell counts in CSF with a defined cut-off value have been proven to be the most accurate to assess the treatment outcome. The intrathecal immunoglobulin M synthesis is a specific and sensitive parameter for the detection of CNS involvement in cases of HAT caused by T. brucei gambiense. The decrease of trypanosome-specific antibodies concentrations in CSF could be a good parameter for definite cure. High CSF IL-10 levels during treatment follow-up indicate recurring CNS inflammation and treatment failure. An increase of Neopterin in CSF and the presence of trypanosome spliced leader RNA in the blood have a high potential as predictors for treatment failure but need further validation.ConclusionNew biomarkers for post-treatment follow-up in HAT should 1) have high diagnostic specificity and sensitivity; 2) be applicable in field conditions; 3) preferentially be performed on blood and thus avoid the painful lumbar puncture during post-treatment control visits; and 4) shorten the follow-up period.

scholarly journals The Flipside of Eradicating a Disease; Human African Trypanosomiasis in a Woman in Rural Democratic Republic of Congo: A Case Report

2019 ◽  
Vol 4 (4) ◽  
pp. 142 ◽  
Author(s):  
Junior Mudji ◽  
Jonathan Benhamou ◽  
Erick Mwamba-Miaka ◽  
Christian Burri ◽  
Johannes Blum
Keyword(s):  
Case Report ◽  
Sleep Disorder ◽  
Human African Trypanosomiasis ◽  
Democratic Republic Of Congo ◽  
Disease Diagnosis ◽  
Tsetse Flies ◽  
Test Results ◽  
African Trypanosomiasis ◽  
Laboratory Test Results ◽  
Two Phases

Human African Trypanosomiasis (HAT) is a neglected disease caused by the protozoan parasites Trypanosoma brucei and transmitted by tsetse flies that progresses in two phases. Symptoms in the first phase include fever, headaches, pruritus, lymphadenopathy, and in certain cases, hepato- and splenomegaly. Neurological disorders such as sleep disorder, aggressive behavior, logorrhea, psychotic reactions, and mood changes are signs of the second stage of the disease. Diagnosis follows complex algorithms, including serological testing and microscopy. Our case report illustrates the course of events of a 41-year old woman with sleep disorder, among other neurological symptoms, whose diagnosis was made seven months after the onset of symptoms. The patient had consulted two different hospitals in Kinshasa and was on the verge of being discharged from a third due to negative laboratory test results. This case report highlights the challenges that may arise when a disease is on the verge of eradication.

The distribution of the tsetse flies Glossina morsitans submorsitans and G. palpalis gambiensis (Diptera: Glossinidae) in The Gambia and the application of survey results to tsetse and trypanosomiasis control

1993 ◽  
Vol 83 (4) ◽  
pp. 625-632 ◽  
Author(s):  
P. Rawlings ◽  
M.L. Ceesay ◽  
T.J. Wacher ◽  
W.F. Snow
Keyword(s):  
Environmental Factors ◽  
The Gambia ◽  
Control Measures ◽  
Evergreen Forest ◽  
General Distribution ◽  
Tsetse Flies ◽  
Glossina Morsitans ◽  
Glossina Morsitans Submorsitans ◽  
Survey Results ◽  
Riparian Habitats

AbstractA country-wide survey of the distribution of tsetse flies Glossina morsitans submorsitans Newstead and G. palpalis gambiensis Vanderplank was carried out in The Gambia, during 1989–1990, using box traps at 1654 sites over an area of 10,000 km2 The general distribution of tsetse had changed little during the last 45 years. G. m. submorsitans was present in dry, canopied woodland throughout most of the country, but was absent from an area south of the River Gambia stretching from the coast to some 100 km inland. G. p. gambiensis occurred in evergreen forest and woodland near the coast, and in riparian habitats along the length of the River Gambia and its major tributaries. Nowhere in the country was more than 20 km from tsetse-infested areas. Five major foci of G. m. submorsitans infestation were identified. Demographic, climatic and environmental factors affect tsetse populations in The Gambia, but it is expected that these foci of infestation will persist for at least the next 5–10 years. The numbers of tsetse trapped, expressed as relative densities, were used to assess the extent and severity of losses from trypanosomiasis to different categories of livestock. Survey results such as these could be used to assess whether control measures to reduce tsetse challenge are likely to be economically viable by using techniques such as insecticide-impregnated targets, pour-ons or chemotherapy.

scholarly journals Livestock, pathogens, vectors, and their environment: a causal inference-based approach to estimating the pathway-specific effect of livestock on human African trypanosomiasis risk

2022 ◽  
Author(s):  
Julianne Meisner ◽  
Agapitus Kato ◽  
Marshall Lemerani ◽  
Erick Mwamba Miaka ◽  
Acaga Ismail Taban ◽  
...  
Keyword(s):  
Environmental Change ◽  
Causal Inference ◽  
Disease Transmission ◽  
Human African Trypanosomiasis ◽  
Spatial Epidemiology ◽  
Specific Effect ◽  
Tsetse Fly ◽  
Tsetse Flies ◽  
African Trypanosomiasis ◽  
Change Effect

Livestock are important reservoirs for many diseases, and investigation of such zoonoses has long been the focus of One Health research. However, the effects of livestock on human and environmental health extend well beyond direct disease transmission.  In this retrospective ecological cohort study we use pre-existing data and methods derived from causal inference and spatial epidemiology to estimate three hypothesized mechanisms by which livestock can come to bear on human African trypanosomiasis (HAT) risk: the reservoir effect, by which infected cattle and pigs are a source of infection to humans; the zooprophylactic effect, by which preference for livestock hosts exhibited by the tsetse fly vector of HAT means that their presence protects humans from infection; and the environmental change effect, by which livestock keeping activities modify the environment in such a way that habitat suitability for tsetse flies, and in turn human infection risk, is reduced. We conducted this study in four high burden countries: at the point level in Uganda, Malawi, and Democratic Republic of Congo (DRC), and at the county-level in South Sudan. Our results indicate cattle and pigs play an important reservoir role for the rhodesiense form (rHAT) in Uganda, however zooprophylaxis outweighs this effect for rHAT in Malawi. For the gambiense form (gHAT) we found evidence that pigs may be a competent reservoir, however dominance of the reservoir versus zooprophylactic pathway for cattle varied across countries. We did not find compelling evidence of an environmental change effect.

The relative potency of insecticides to tsetse flies assessed by two methods

1967 ◽  
Vol 57 (2) ◽  
pp. 321-326 ◽  
Author(s):  
J. R. Busvine ◽  
U. Abdurrahim ◽  
N. N. Mohammed
Keyword(s):  
Topical Application ◽  
Young Male ◽  
Pregnant Female ◽  
Relative Potency ◽  
Tsetse Flies ◽  
Physical Factors ◽  
Glossina Morsitans ◽  
Factors Affecting ◽  
Glossina Morsitans Submorsitans ◽  
The Difference

The insecticidal Potencies of DDT, dieldrin, isobenzan, malathion, diazinon and arprocarb were assessed both by topical application of oil solutions to test insects any by exposing the latter to residues on glass, using young male and non-pregnant female adults of Glossina morsitans submorsitans Newst., G. austebi Newst., and Chrysomya putoria (Wied.).By topical application, dieldrin and isobenzan were 10–23 times as potent as DDT, but their residues were on ly 2.2–6.3 times as effective; arprocarb was likewise more effective by topical application than as a residue, being, respectively, 9 and 3.5 times as effective as DDT. In contrast, diazinon, and, especially, malathion tended to be more efficient, relative to DDT, as residues than might be expected from application tests.It is presumed that the difference between the ralative potency of an insecticide as a reesidue and as applied topically reflects the physical factors affecting contamination and penetration of the insect, but these matters have nor been stuided with tsetse flies.

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