UV-PROTECTIVE SUNGLASSES FOR UVA IRRADIATION PROTECTION

1995 ◽  
Vol 34 (11) ◽  
pp. 808-810 ◽  
Author(s):  
YUNG HIAN LEOW ◽  
SIEW NEE THAM
Antioxidants ◽  
2020 ◽  
Vol 9 (10) ◽  
pp. 912
Author(s):  
Mirae An ◽  
Hyungkeun Kim ◽  
Joo-Myung Moon ◽  
Hyun-Soo Ko ◽  
Paul Clayton ◽  
...  

Ultraviolet A (UVA) is a risk factor for photoaging and wrinkle formation. Zizania latifolia is an herbaceous perennial plant. It contains many bioactive compounds such as tricin that show antioxidative and anti-inflammatory effects. The aim of this study was to investigate the antiwrinkle effect of a mixture of hydrolytic enzyme (cellulase, hemicellulase and pectinase)-treated Z. latifolia extract (ZLE) and tricin on UVA-irradiated human dermal fibroblasts (HDFs) and SKH-1 hairless mice. Treatment of UVA-irradiated HDF cells with ZLE and tricin significantly decreased UVA induced-plasma membrane rupture, generation of ROS, expression levels of total and secreted lysosomal associated membrane protein (LAMP-1), cathepsin B and metalloproteinases (MMPs) and inhibited NF-κB activation. In the animal study, UVA-damaged epidermal and dermal tissues were repaired by the ZLE and tricin treatments. Administration of ZLE or tricin to UVA-irradiated animals recovered skin surface moisture and collagen fiber in dermal tissue. Treatment of ZLE or tricin decreased wrinkle formation, secretion of MMPs and expression levels of vascular endothelial growth factor (VEGF) and cathepsin B, and increased the expression level of collagen-1 in UVA-irradiated animals. Overall, the ZLE and tricin treatments decreased the skin damage induced by UVA irradiation via inhibition of lysosomal exocytosis and ROS generation. Therefore, ZLE and tricin are promising as antiwrinkle and antiphotoaging agents.


2008 ◽  
Vol 90 (1) ◽  
pp. 53-56
Author(s):  
Xiaoqiang Liang ◽  
Guifang Chen ◽  
Xin Zhang ◽  
Shanli Liu ◽  
Genxi Li
Keyword(s):  

Redox Report ◽  
2013 ◽  
Vol 19 (2) ◽  
pp. 72-79 ◽  
Author(s):  
Saadettin Sel ◽  
Norbert Nass ◽  
Sandy Pötzsch ◽  
Stefanie Trau ◽  
Andreas Simm ◽  
...  

Molecules ◽  
2018 ◽  
Vol 23 (4) ◽  
pp. 721 ◽  
Author(s):  
Michal Hricovíni ◽  
Milan Mazúr ◽  
Angela Sîrbu ◽  
Oleg Palamarciuc ◽  
Vladimir Arion ◽  
...  

2021 ◽  
Vol 2021 ◽  
pp. 1-13
Author(s):  
Hervé Pageon ◽  
Hélène Zucchi ◽  
Sylvie Ricois ◽  
Philippe Bastien ◽  
Daniel Asselineau

Skin aging is the result of superimposed intrinsic (individual) and extrinsic (e.g., UV exposure or nutrition) aging. Previous works have reported a relationship between UV irradiation and glycation in the aging process, leading, for example, to modified radical species production and the appearance of AGEs (advanced glycosylation end products) in increasing quantities, particularly glycoxidation products like pentosidine. In addition, the colocalization of AGEs and elastosis has also been observed. We first investigated the combination of the glycation reaction and UVA effects on a reconstructed skin model to explain their cumulative biological effect. We found that UVA exposure combined with glycation had the ability to intensify the response for specific markers: for example, MMP1 or MMP3 mRNA, proteases involved in extracellular matrix degradation, or proinflammatory cytokine, IL1α, protein expression. Moreover, the association of glycation and UVA irradiation is believed to promote an environment that favors the onset of an elastotic-like phenomenon: mRNA coding for elastin, elastase, and tropoelastin expression is increased. Secondly, because the damaging effects of UV radiation in vivo might be more detrimental in aged skin than in young skin due to increased accumulation of pentosidine and the exacerbation of alterations related to chronological aging, we studied the biological effect of soluble pentosidine in fibroblasts grown in monolayers. We found that pentosidine induced upregulation of CXCL2, IL8, and MMP12 mRNA expression (inflammatory and elastotic markers, respectively). Tropoelastin protein expression (elastin precursor) was also increased. In conclusion, fibroblasts in monolayers cultured with soluble pentosidine and tridimensional in vitro skin constructs exposed to the combination of AGEs and UVA promote an inflammatory state and an alteration of the dermal compartment in relation to an elastosis-like environment.


Sign in / Sign up

Export Citation Format

Share Document