CELL INFILTRATEN PROGRESSIVE PIGMENTED PURPURA (SCHAMBERG'S DISEASE): IMMUNOPHENOTYPE, ADHESION RECEPTORS, AND INTERCELLULAR RELATIONSHIPS

Integrins and other families of cell adhesion receptors are responsible for platelet adhesion and aggregation, which are essential steps for physiological haemostasis, as well as for the development of thrombosis. The modulation of platelet adhesive properties is the result of a complex pattern of inside-out and outside-in signaling pathways, in which the members of the Rap family of small GTPases are bidirectionally involved. This paper focuses on the regulation of the main Rap GTPase expressed in circulating platelets, Rap1b, downstream of adhesion receptors, and summarizes the most recent achievements in the investigation of the function of this protein as regulator of platelet adhesion and thrombus formation.

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Epidermal growth factor modifies the expression and function of extracellular matrix adhesion receptors expressed by peritoneal mesothelial cells from patients on CAPD

Nephrology Dialysis Transplantation ◽

10.1093/ndt/14.5.1208 ◽

1999 ◽

Vol 14 (5) ◽

pp. 1208-1216 ◽

Cited By ~ 37

Author(s):

D Leavesley

Keyword(s):

Extracellular Matrix ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Mesothelial Cells ◽

Adhesion Receptors ◽

Peritoneal Mesothelial Cells ◽

Matrix Adhesion ◽

Epidermal Growth ◽

And Function

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Protein tyrosine phosphatases as adhesion receptors

Current Opinion in Cell Biology ◽

10.1016/0955-0674(95)80106-5 ◽

1995 ◽

Vol 7 (5) ◽

pp. 650-657 ◽

Cited By ~ 134

Author(s):

S Brady-Kalnay

Keyword(s):

Protein Tyrosine Phosphatases ◽

Tyrosine Phosphatases ◽

Adhesion Receptors ◽

Protein Tyrosine

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Predicting cell adhesion receptors using protein sequence index

Open Access Bioinformatics ◽

10.2147/oab.s17492 ◽

2011 ◽

pp. 97 ◽

Cited By ~ 2

Author(s):

Zhijun Wang ◽

Xu Chunyan ◽

Yu Feng ◽

Lin Tang ◽

Jianhua He ◽

...

Keyword(s):

Cell Adhesion ◽

Protein Sequence ◽

Adhesion Receptors

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Molecular organisation of cell–matrix contacts: essential multiprotein assemblies in cell and tissue function

Expert Reviews in Molecular Medicine ◽

10.1017/s1462399402004039 ◽

2002 ◽

Vol 4 (1) ◽

pp. 1-24 ◽

Cited By ~ 8

Author(s):

Josephine Clare Adams

Keyword(s):

Extracellular Matrix ◽

Inflammatory Responses ◽

Specific Cell ◽

Functional Categories ◽

Adhesion Receptors ◽

Surface Receptors ◽

Signalling Molecules ◽

Cell Matrix ◽

Molecular Organisation ◽

Specific Cell Surface

The adhesion of cells to their surrounding extracellular matrix has vital roles in embryonic development, inflammatory responses, wound healing and adult tissue homeostasis. Cells attach to extracellular matrix by specific cell-surface receptors, of which the integrins and transmembrane proteoglycans are major representatives. The engagement of adhesion receptors triggers assembly of functional matrix contacts, in which bound matrix components, adhesion receptors and associated intracellular cytoskeletal and signalling molecules form large, localised multiprotein complexes. This review discusses the functional categories of matrix contacts, examples of the biological roles of matrix contacts in normal physiology, and examples of the ways in which abnormalities of matrix contacts are associated with major human diseases.

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