scholarly journals Structure of the human gene encoding granule membrane protein-140, a member of the selectin family of adhesion receptors for leukocytes.

1990 ◽  
Vol 265 (34) ◽  
pp. 21381-21385 ◽  
Author(s):  
G I Johnston ◽  
G A Bliss ◽  
P J Newman ◽  
R P McEver
Keyword(s):  
Membrane Protein ◽  
Human Gene ◽  
Adhesion Receptors ◽  
Gene Encoding ◽  
Granule Membrane ◽  
Selectin Family

scholarly journals LAG-3, a novel lymphocyte activation gene closely related to CD4.

1990 ◽  
Vol 171 (5) ◽  
pp. 1393-1405 ◽  
Author(s):  
F Triebel ◽  
S Jitsukawa ◽  
E Baixeras ◽  
S Roman-Roman ◽  
C Genevee ◽  
...  
Keyword(s):  
Amino Acid ◽  
Membrane Protein ◽  
Distal Part ◽  
Human Gene ◽  
Lymphocyte Activation ◽  
Chromosome 12 ◽  
Disulphide Bridge ◽  
Gene Encoding ◽  
Ig Superfamily ◽  
Lymphocyte Activation Gene

We have identified a novel human gene of the Ig superfamily, designated LAG-3. Expression of this gene is undetectable in resting PBL, while it is found (a 2-kb message) in activated T and NK cells. The LAG-3 gene includes eight exons; the corresponding cDNA encodes a 498-amino acid membrane protein with four extracellular IgSF domains. The first one belongs to the V-SET; it is particular since it includes an extra loop in the middle of the domain and an unusual intrachain disulphide bridge. The three other domains belong to the C2-SET. Strong internal homologies are found in the LAG-3 molecule between domains 1 and 3, as well as between domains 2 and 4. It is therefore likely that LAG-3 has evolved by duplication of a pre-existing gene encoding a two IgSF-domain structure. The compared analysis of LAG-3 and CD4, with respect to both their peptidic sequence as well as their exon/intron organization, indicated that the two molecules are closely related. This point is strengthened by the finding that both genes are located on the distal part of the short arm of chromosome 12.

Association analysis of the Arg220His variation of the human gene encoding the GABA δ subunit with idiopathic generalized epilepsy

2005 ◽  
Vol 65 (1-2) ◽  
pp. 53-57 ◽  
Author(s):  
Kirsten P. Lenzen ◽  
Armin Heils ◽  
Susanne Lorenz ◽  
Anne Hempelmann ◽  
Thomas Sander
Keyword(s):  
Association Analysis ◽  
Human Gene ◽  
Idiopathic Generalized Epilepsy ◽  
Gene Encoding ◽  
Generalized Epilepsy
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