Clinical course and pathologic findings of successful second ABO-incompatible renal transplantation in a patient with donor-specific anti-HLA antibody

The clinical, laboratory and pathologic findings of a series of cases of cat scratch syndrome have been reviewed. In spite of a variable clinical course, certain features associated with a selected group of laboratory tests appear to be constant enough to be of diagnostic value. A history of contact with a cat and/or scratch which is usually associated with a peripheral skin lesion, lack of lymphangitis, presence of regional lymphadenopathy with tenderness to palpation are the most constant clinical findings. Fever, so frequently emphasized as a characteristic clinical sign, may be extremely variable in type and duration or entirely absent. A skin test with cat scratch antigen has been positive in all cases. Lacking this antigen, a negative Frei skin test in conjunction with a positive complement fixation test (Lygranum C. F.) is suggestive evidence for the diagnosis. With positive evidence from the above data, biopsy of an affected gland with its relatively nonspecific pathologic picture is not considered essential for the establishment of the diagnosis of cat scratch syndrome.

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Cytomegalovirus-Associated Hemophagocytic Syndrome

PEDIATRICS ◽

10.1542/peds.75.2.280 ◽

1985 ◽

Vol 75 (2) ◽

pp. 280-283

Author(s):

ELIZABETH H. DANISH ◽

BEVERLY B. DAHMS ◽

MARY L. KUMAR

Keyword(s):

Viral Infection ◽

Epstein Barr Virus ◽

Hemophagocytic Syndrome ◽

Clinical Course ◽

Underlying Disease ◽

Barr Virus ◽

Pathologic Findings ◽

Immunosuppressed Patients ◽

Epstein Barr ◽

Herpes Group

Virus-associated hemophagocytic syndrome, first described by Risdall and co-workers in 1979,1 is a rare histiocytic proliferative syndrome characterzed by fever, hepatosplenomegaly, pancytopenia, and erythrophagocytosis by histiocytes that appear benign by histologic criteria. The clinical course and pathologic findings may be identical with another histiocytic disorder, familial erythrophagocytic lymphohistiocytosis, which occurs predominantly in infants. Diagnosis of virus-associated hemophagocytic syndrome depends entirely on evidence of concurrent viral infection, usually of the herpes group. Epstein-Barr virus has been associated with this syndrome in the few cases reported in children without underlying disease, whereas cytomegalovirus (CMV) has been implicated in immunosuppressed patients. We report a case of fatal CMV-associated hemophagocytic syndrome which occurred in a previously healthy infant.

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Deceased Donor HLA Antibody Incompatible Renal Transplantation without Antibody Removal: High Incidence of Acute Rejection Reduced by T-Cell Depleting Induction Therapy

Transplantation Journal ◽

10.1097/00007890-201211271-02133 ◽

2012 ◽

Vol 94 (10S) ◽

pp. 1076

Author(s):

E. C. Jolly ◽

C. J. Taylor ◽

T. Key ◽

H. Morgan ◽

S. Peacock ◽

...

Keyword(s):

Renal Transplantation ◽

T Cell ◽

Acute Rejection ◽

Induction Therapy ◽

Deceased Donor ◽

High Incidence ◽

Hla Antibody

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Expanding Spectrum of Toxoplasma gondii: Thymoma and Toxoplasmic Encephalitis

Open Forum Infectious Diseases ◽

10.1093/ofid/ofy163 ◽

2018 ◽

Vol 5 (7) ◽

Author(s):

Daniel B Chastain ◽

Joeanna I Sams ◽

Gregory M Steele ◽

Lindsey O Lowder ◽

Carlos Franco-Paredes

Keyword(s):

Toxoplasma Gondii ◽

Parietal Lobe ◽

Clinical Course ◽

Toxoplasmic Encephalitis ◽

Good’S Syndrome ◽

Pathologic Findings

Abstract In this brief report, we describe a 76-year-old patient with thymoma who underwent craniotomy for a left parietal lobe mass with pathologic findings consistent with Toxoplasma gondii encephalitis in the absence of any features of thymoma with immunodeficiency/Good’s syndrome. His clinical course suggested likely Toxoplasma reactivation.

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Acute lead arsenate poisoning in beef cattle in Uruguay

Journal of Veterinary Diagnostic Investigation ◽

10.1177/1040638719831413 ◽

2019 ◽

Vol 31 (2) ◽

pp. 307-310 ◽

Cited By ~ 2

Author(s):

Carlos O. Schild ◽

Federico Giannitti ◽

Rosane M. T. Medeiros ◽

Caroline da Silva Silveira ◽

Rubén D. Caffarena ◽

...

Keyword(s):

Beef Cattle ◽

Clinical Course ◽

Lymphoid Organs ◽

Lymphoid Tissues ◽

Lead Arsenate ◽

Pathologic Findings ◽

Lead Levels ◽

Baccharis Coridifolia ◽

Orange Orchard ◽

Toxic Plant

We describe and illustrate lesions in an outbreak of lead arsenate poisoning in beef cattle that ingested pesticide residues stored in an abandoned building of a former orange orchard. Of 70 exposed cattle, 14 had diarrhea, paresis, ataxia, recumbency, and/or seizures. Ten of the affected animals died after a clinical course of 12–18 h. Pathologic findings in 3 steers included extensive necrohemorrhagic, ulcerative rumenitis, omasitis, and abomasitis; lymphocytolysis in lymphoid organs; and nephrosis. Hepatic arsenic and lead levels in cases 1–3 were 20, 24, and 31 ppm, and 8.3, 25, and 9.4 ppm, respectively. Lesions in the forestomachs and lymphoid tissues have been rarely reported in cases of lead arsenate poisoning. In southern South America, these lesions are indistinguishable from those produced by Baccharis coridifolia, a toxic plant that contains macrocyclic trichothecenes, thus these conditions should be considered in the differential diagnosis of necrotizing lesions in alimentary and lymphoid organs.

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Successful Triplet Pregnancy following Renal Transplantation

Scottish Medical Journal ◽

10.1177/003693308002500416 ◽

1980 ◽

Vol 25 (4) ◽

pp. 320-322 ◽

Cited By ~ 8

Author(s):

A. B. MacLean ◽

F. Sharp ◽

J. D. Briggs ◽

S. G. MacPherson

Keyword(s):

Renal Transplantation ◽

Renal Transplant ◽

Clinical Course ◽

Renal Transplant Recipients ◽

Transplant Recipients ◽

Triplet Pregnancy ◽

Successful Case

There are now many reported successful pregnancies to renal transplant recipients, but this is believed to be the first reported successful case of triplets. The clinical course, complications and management of the pregnancy are described.

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