CAT SCRATCH SYNDROME

PEDIATRICS ◽  
1952 ◽  
Vol 10 (3) ◽  
pp. 311-318
Author(s):  
WILLIAM J. WATERS ◽  
SEYMOUR S. KALTER ◽  
JOHN T. PRIOR
Keyword(s):  
Skin Test ◽  
Laboratory Tests ◽  
Complement Fixation Test ◽  
Complement Fixation ◽  
Clinical Laboratory ◽  
Clinical Course ◽  
Diagnostic Value ◽  
Clinical Findings ◽  
Pathologic Findings ◽  
History Of

The clinical, laboratory and pathologic findings of a series of cases of cat scratch syndrome have been reviewed. In spite of a variable clinical course, certain features associated with a selected group of laboratory tests appear to be constant enough to be of diagnostic value. A history of contact with a cat and/or scratch which is usually associated with a peripheral skin lesion, lack of lymphangitis, presence of regional lymphadenopathy with tenderness to palpation are the most constant clinical findings. Fever, so frequently emphasized as a characteristic clinical sign, may be extremely variable in type and duration or entirely absent. A skin test with cat scratch antigen has been positive in all cases. Lacking this antigen, a negative Frei skin test in conjunction with a positive complement fixation test (Lygranum C. F.) is suggestive evidence for the diagnosis. With positive evidence from the above data, biopsy of an affected gland with its relatively nonspecific pathologic picture is not considered essential for the establishment of the diagnosis of cat scratch syndrome.

scholarly journals NON-SPECIFIC ULCERATIVE COLITIS AND COVID-19, A CASE STUDY

2021 ◽  
Vol 5 (1) ◽  
pp. 89-92
Author(s):  
Z. P. Lemeshevskaya ◽  
◽  
M. V. Pavlukevich ◽  
N. I. Procopchik ◽  
◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Clinical Case ◽  
Clinical Laboratory ◽  
Clinical Course ◽  
Medical Documentation ◽  
Atypical Form ◽  
History Of ◽  
Hematoxylin And Eosin ◽  
Somatic Diseases

Background. COVID-19 infection keeps changing our understanding of its clinical course when associated with various somatic diseases. Objective. To present a clinical case of a patient with non-specific ulcerative colitis (NUC) and COVID-19 infection. Material and methods: medical documentation, general clinical, laboratory and instrumental data as well as histological examination of bioptates stained with hematoxylin and eosin that were obtained during colonoscopy. Results. The article presents a case history of a patient with manifestations of severe total NUC developed in association with the subclinical form of COVID-19 infection, the former being the cause of death in concomitant pathology. Conclusions. This clinical case describes a variant of an unfavorable outcome of NUC, one of the reasons for the manifestation of which was the atypical form of COVID-19 infection, which became a trigger for an autoimmune inflammatory process in the intestine. The accumulation of new knowledge about the features of the pathogenesis and manifestations of both pathologies will make it possible to improve the effectiveness of treatment and predict the course and outcomes of combined pathology.

scholarly journals Brill–Zinsser disease; the possibility of its occurrence in Britain

1958 ◽  
Vol 56 (3) ◽  
pp. 355-363 ◽  
Author(s):  
H. S. Lawy ◽  
C. P. Beattie ◽  
H. J. Bensted
Keyword(s):  
Technical Assistance ◽  
Complement Fixation Test ◽  
Complement Fixation ◽  
Harvard University ◽  
Severe Headache ◽  
Eastern European ◽  
European Origin ◽  
Epidemic Typhus ◽  
History Of ◽  
Typhus Fever

1. Of 318 Polish refugees now living in this country 30% gave a history of typhus fever; nearly half of these had complement-fixing antibodies to a titre of 1–5 or more to epidemic typhus. A further 12% without such a history similarly had these antibodies making a total of 22% of 318 refugees. None of the 174 British born controls had antibodies up to this titre.2. Brill-Zinsser disease may occur from time to time among immigrants or visitors from typhus endemic areas to this country, but it is unlikely to be a serious problem.3. The clinical diagnosis of Brill-Zinsser disease may not be easy because the characteristic rash is not always to be seen. Any patient of Eastern European origin or who has a history of typhus complaining of fever and severe headache should be examined serologically by the rickettsial agglutination or the complement-fixation test for specific epidemic typhus antibodies. The Weil-Felix reaction may be positive, but a negative result will not exclude a diagnosis of Brill-Zinsser disease.We acknowledge with gratitude the help, interest and advice of Dr E. S. Murray, of the School of Public Health, Harvard University and Dr Janet Niven and also the technical assistance of Mr J. P. Brooks, FIMLT. We have to thank Messrs Lederle for their kindness in supplying the rickettsial antigens and in addition those who helped us to obtain the specimens and the volunteers who supplied them.

scholarly journals DIAGNOSTIC VALUE OF TEST WITH AUTOLOGOUS SERUM IN PATIENTS WITH EXACERBATION OF CHRONIC IDIOPATHIC URTICARIA

2012 ◽  
Vol 9 (5) ◽  
pp. 26-30
Author(s):  
R N Golubchikova ◽  
I V Danilycheva
Keyword(s):  
Skin Test ◽  
Clinical Laboratory ◽  
Severe Disease ◽  
Diagnostic Value ◽  
Chronic Idiopathic Urticaria ◽  
Positive Skin Test ◽  
Autologous Serum ◽  
Thyroid Antibodies ◽  
Laboratory Findings ◽  
Positive Skin

Background. A comparative study of the severity of CIU, effectiveness of antihistamines and determination the frequency of patients with and without thyroid antibodies among patients with CIU in groups with different skin sensitivity to autologous serum. Methods. The retrospective study of the anamnestic clinical laboratory findings in patients with chronic idiopathic. Results. 46% of patients had a positive skin test with autologous serum. A positive skin test with autologous serum was dominated in patients with severe disease, the lack of efficacy of antihistamines, and patients with anti-thyroid antibodies.

scholarly journals Clinical Misdiagnosis of COVID-19 Infection with Confusing Clinical Course

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Hamid Eshaghi ◽  
Vahid Ziaee ◽  
Mahmood Khodabande ◽  
Moeinadin Safavi ◽  
Elmira Haji Esmaeil Memar
Keyword(s):  
Bone Marrow ◽  
Laboratory Tests ◽  
Clinical Symptoms ◽  
Clinical Course ◽  
Bone Marrow Aspiration ◽  
Abdominal Ultrasound ◽  
Left Lobe ◽  
Tropical Countries ◽  
History Of ◽  
Clinical Conditions

Background. Similarities in the febrile course and other manifestations of some diseases may lead to clinical misdiagnosis of COVID-19 infection. Here, we report a case in a young child with a potentially confusing clinical course. Case Presentation. A 29-month-old boy presented with a 2-month history of fever. His PCR test for COVID-19 was positive, and there was pleural effusion plus positive findings in the lower left lobe of the lung on computed tomography scan. Mid-sized splenomegaly was found on abdominal ultrasound, and laboratory tests disclosed pancytopenia. In light of the atypical lymphocyte counts in laboratory tests, he underwent bone marrow aspiration. The suggested diagnosis was hemophagocytic lymphohistiocytosis, and prednisolone was initiated. Subsequently, Leishman-Donovan bodies were seen in the bone marrow aspirate, and treatment was started with amphotericin, which led to clinical improvement. Conclusion. In cases with vague clinical symptoms in tropical countries where other infectious diseases occur, possible simultaneous infection should be considered even during a pandemic. Familiarity with the possible differential diagnoses and appropriate, step-by-step consideration to rule out other possible causes are needed in all situations, and the coexistence of infectious disease should be considered in evaluating the clinical conditions of patients in tropical countries.

scholarly journals Clinical Coccidiosis in a Boar Stud

2003 ◽  
Vol 15 (4) ◽  
pp. 387-389 ◽  
Author(s):  
Michael J. Yaeger ◽  
Andrew Holtcamp ◽  
Julie A. Jarvinen
Keyword(s):  
Small Intestine ◽  
Antibiotic Therapy ◽  
Laboratory Tests ◽  
Clinical Course ◽  
Clinical Signs ◽  
State University ◽  
Iowa State University ◽  
Diagnostic Laboratory ◽  
Fecal Samples ◽  
History Of

This report describes an outbreak of coccidiosis in a boar stud. A live, untreated, adult boar with a history of diarrhea was submitted to the Iowa State University Veterinary Diagnostic Laboratory, Ames, IA. For a 3-month period, approximately 40% of the boars in this stud had developed gray to brown diarrhea that lasted 1–3 days. Affected boars did not lose condition, and antibiotic therapy did not appear to affect the clinical course of the disease. At necropsy, the distal ileum was palpably thickened and covered by a thick, yellow-green, fibrinous exudate. Microscopic changes in the ileum consisted of an erosive enteritis associated with the presence of numerous coccidia within mid to superficial villus enterocytes. The mucosa was covered by a fibrinous exudate admixed with numerous nonsporulated coccidian oocysts. A light growth of Salmonella enterica serovar Derby was isolated from the small intestine of this animal, but laboratory tests were negative for Lawsonia and Brachyspira spp. Individual or paired fecal samples were obtained from 6 additional boars experiencing similar clinical signs. Numerous Eimeria spinosa oocysts were identified in these samples. Neither Salmonella nor Brachyspira spp. were cultured from submitted fecal samples. Necropsy of a live boar and examination of feces from 6 additional animals confirmed that the mild, sporadic, transient diarrhea in this boar stud was due to coccidiosis.

A STUDY OF VARIOUS FRACTIONS OF BRUCELLA ABORTUS: II. COMPLEMENT FIXATION AND INTRADERMAL TESTS WITH ALCOHOLIC PRECIPITATE

1935 ◽  
Vol 12 (1) ◽  
pp. 125-132
Author(s):  
Ronald Gwatkin
Keyword(s):  
Skin Test ◽  
Brucella Abortus ◽  
Guinea Pigs ◽  
Complement Fixation Test ◽  
Complement Fixation ◽  
Fixation Test ◽  
Skin Reactions ◽  
Three Samples ◽  
Intradermal Tests

Alcoholic precipitates of Brucella abortus showed high antigenic qualities in the complement fixation test. Dialysis and filtration did not lower this activity. The precipitates gave rise to reactions in infected guinea pigs, in dilutions which produced no change in normal animals. Filtration did not modify the results. In two out of three samples dialysis did not lower the activity of the suspensions as skin test antigens. The addition of formol did not modify the skin reactions.

scholarly journals OBSERVATIONS UPON THE NOGUCHI MODIFICATION OF THE WASSERMANN COMPLEMENT FIXATION TEST IN THE DIAGNOSIS OF LUES IN THE MILITARY SERVICE

1910 ◽  
Vol 12 (6) ◽  
pp. 726-745
Author(s):  
Charles F. Craig
Keyword(s):  
Military Service ◽  
Complement Fixation Test ◽  
Complement Fixation ◽  
Specific Treatment ◽  
Clinical Findings ◽  
Fixation Test ◽  
Medical Department ◽  
Clinical Observations ◽  
The Military ◽  
Military Services

In the vast majority of cases examined in this laboratory the result of the Wassermann test was simply confirmatory of the clinical findings, but there were numerous suspicious cases, or cases in which symptoms were present and the patient denied a specific history, in which the test was of the greatest value, and it is in such instances, perhaps, that it may be regarded as "the court of last resort " in arriving at a conclusion regarding the nature of the condition present. Certainly if there is any value in experience and statistics, we are justified in regarding this test as the most valuable means we possess of diagnosing lues, and our experience with the Noguchi modification of the test has justified all that has been claimed for that method. We believe that our results have proven that by the use of the complement fixation test in the military service it is possible to prevent the enlistment of men suffering from latent lues who would otherwise be enlisted; to control specific treatment by using it as an index of the efficiency of such treatment; to clear up the diagnosis of obscure or suspicious cases; and to enable the surgeon to avoid mistakes in discharges for disability in cases suspected of this disease. Owing to the facility with which clinical observations can be made in armies, and the control that is possible of tested individuals, it is to be hoped that the Noguchi modification of the complement fixation test will be more widely used than it has been in the military services, for which we believe it is especially adapted. So far as we are aware the Medical Department of our army is the first to adopt this test as a routine diagnostic procedure and to apply it in the case of applicants for enlistment.

Encephalopathy associated with occult neuroblastoma

1974 ◽  
Vol 41 (5) ◽  
pp. 567-572 ◽  
Author(s):  
Bruce O. Berg ◽  
Arthur R. Ablin ◽  
Winfred Wang ◽  
Rayburn Skoglund
Keyword(s):  
Mandelic Acid ◽  
Clinical Course ◽  
Diagnostic Value ◽  
Clinical Findings ◽  
Intravenous Pyelogram ◽  
Content Type ◽  
Vanillyl Mandelic Acid ◽  
Fine Print

✓ The authors report four cases of occult neuroblastoma in children with the striking clinical findings of opsoclonus, myoclonus, and ataxia. The diagnostic value of plain roentgenograms of the chest and abdomen or an intravenous pyelogram is emphasized. Assays for vanillyl mandelic acid and cystathionine may be of value. The clinical course and pathogenesis of encephalopathies due to neuroblastoma are discussed.

scholarly journals Clinical and Laboratory Characteristics of a Large Iranian Kindred Afflicted with Von Hippel Lindau Disease

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Ali Asghar Mir Saeid Ghazi ◽  
Atieh Amouzegar ◽  
Azita Zadeh-Vakili ◽  
Abdolreza Sheikh Rezaei ◽  
Alireza Amirbaigloo ◽  
...  
Keyword(s):  
Clinical Laboratory ◽  
Malignant Tumors ◽  
Positive Family History ◽  
Clinical Findings ◽  
Kidney Tumors ◽  
Genetic Characteristics ◽  
Von Hippel Lindau ◽  
Study Results ◽  
History Of ◽  
Retinal Hemangioblastoma

Introduction: Von Hippel Lindau (VHL) disease is a hereditary disorder characterized by the development of benign or malignant tumors in the brain, spinal cord, eyes, adrenal medulla, kidney, pancreas, and many other organs. Advances in molecular diagnosis have led to the identification of the affected members of families at earlier stages. We present the clinical, laboratory, and genetic characteristics of five generations of large Iranian kindred with VHL. Case Presentation: The proband, a 52-year-old Iranian man, was recognized with VHL. All family members underwent clinical, laboratory, imaging, and genetic evaluation. Medical files and histopathology reports of patients who had been operated on before were also reviewed. Diagnosis of the disease was based on clinical findings, positive family history of VHL, and development of a central nervous system or retinal hemangioblastoma or pheochromocytoma. Based on diagnostic criteria, our initial evaluations revealed that 10 members of the family had already been affected by the disease. Among them, nine had pheochromocytoma, and one had retinal hemangioblastoma. There was no case of kidney tumors among the kindred. Conclusions: Study results show the high penetrance of the disease and focus on the large burden imposed by the disease on the health and quality of life of patients afflicted with the disease, emphasizing the importance of surveillance from early childhood for detection and management of the disease as early as possible.

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