scholarly journals Multinational study in children and adolescents with newly diagnosed type 1 diabetes: association of age, ketoacidosis, HLA status, and autoantibodies on residual beta-cell function and glycemic control 12 months after diagnosis

2009 ◽  
Vol 11 (4) ◽  
pp. 218-226 ◽  
Author(s):  
Henrik B Mortensen ◽  
Peter GF Swift ◽  
Reinhard W Holl ◽  
P Hougaard ◽  
Lars Hansen ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Glycemic Control ◽  
Beta Cell ◽  
Children And Adolescents ◽  
Beta Cell Function ◽  
Cell Function ◽  
Multinational Study ◽  
Newly Diagnosed

Factors predicting residual beta cell function in children with newly-diagnosed type 1 diabetes

1990 ◽  
Vol 3 (1) ◽  
pp. 56
Author(s):  
J.J. Cook ◽  
I.L. Hudson ◽  
G.A. Werther ◽  
G.L. Warne ◽  
J.M. Court ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Beta Cell ◽  
Beta Cell Function ◽  
Cell Function ◽  
Newly Diagnosed

Beta cell function and BMI in ethnically diverse children with newly diagnosed autoimmune type 1 diabetes

2012 ◽  
Vol 13 (7) ◽  
pp. 564-571 ◽  
Author(s):  
Maria J. Redondo ◽  
Luisa M. Rodriguez ◽  
Mirna Escalante ◽  
E. O'Brian Smith ◽  
Ashok Balasubramanyam ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Beta Cell ◽  
Beta Cell Function ◽  
Cell Function ◽  
Ethnically Diverse ◽  
Newly Diagnosed ◽  
Diverse Children

scholarly journals Residual beta cell function at diagnosis of type 1 diabetes in children and adolescents varies with gender and season

2013 ◽  
Vol 29 (1) ◽  
pp. 85-89 ◽  
Author(s):  
U. Samuelsson ◽  
B. Lindblad ◽  
A. Carlsson ◽  
G. Forsander ◽  
S. Ivarsson ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Beta Cell ◽  
Children And Adolescents ◽  
Beta Cell Function ◽  
Cell Function

scholarly journals Circulating Levels of MicroRNA from Children with Newly Diagnosed Type 1 Diabetes and Healthy Controls: Evidence That miR-25 Associates to Residual Beta-Cell Function and Glycaemic Control during Disease Progression

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Lotte B. Nielsen ◽  
Cheng Wang ◽  
Kaspar Sørensen ◽  
Claus H. Bang-Berthelsen ◽  
Lars Hansen ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Glycaemic Control ◽  
Beta Cell ◽  
Beta Cell Function ◽  
Cell Function ◽  
Control Group ◽  
Healthy Controls ◽  
Newly Diagnosed ◽  
New Onset

This study aims to identify key miRNAs in circulation, which predict ongoing beta-cell destruction and regeneration in children with newly diagnosed Type 1 Diabetes (T1D). We compared expression level of sera miRNAs from new onset T1D children and age-matched healthy controls and related the miRNAs expression levels to beta-cell function and glycaemic control. Global miRNA sequencing analyses were performed on sera pools from two T1D cohorts (n= 275 and 129, resp.) and one control group (n= 151). We identified twelve upregulated human miRNAs in T1D patients (miR-152, miR-30a-5p, miR-181a, miR-24, miR-148a, miR-210, miR-27a, miR-29a, miR-26a, miR-27b, miR-25, miR-200a); several of these miRNAs were linked to apoptosis and beta-cell networks. Furthermore, we identified miR-25 as negatively associated with residual beta-cell function (est.: −0.12,P= 0.0037), and positively associated with glycaemic control (HbA1c) (est.: 0.11,P= 0.0035) 3 months after onset. In conclusion this study demonstrates that miR-25 might be a “tissue-specific” miRNA for glycaemic control 3 months after diagnosis in new onset T1D children and therefore supports the role of circulating miRNAs as predictive biomarkers for tissue physiopathology and potential intervention targets.

scholarly journals Residual Beta Cell Function in Newly Diagnosed Type 1 Diabetes after Treatment with Atorvastatin: The Randomized DIATOR Trial

PLoS ONE ◽  
2011 ◽  
Vol 6 (3) ◽  
pp. e17554 ◽  
Author(s):  
Stephan Martin ◽  
Christian Herder ◽  
Nanette C. Schloot ◽  
Wolfgang Koenig ◽  
Tim Heise ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Beta Cell ◽  
Beta Cell Function ◽  
Cell Function ◽  
Newly Diagnosed
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