Zur Wirksamkeit von Fenbendazol1 gegen adulte und immature Stadien von Nematospiroides dubius und Heterakis spumosa2

2010 ◽  
Vol 22 (6) ◽  
pp. 441-447 ◽  
Author(s):  
R. Kirsch
Keyword(s):  
Nematospiroides Dubius

Some effects of the diet of mice on Nematospiroides dubius (Nematoda)

Parasitology ◽  
1969 ◽  
Vol 59 (1) ◽  
pp. 203-213 ◽  
Author(s):  
R. J. Bawden
Keyword(s):  
Technical Assistance ◽  
Growth Potential ◽  
The Other ◽  
Adequate Diet ◽  
Female Mice ◽  
Other Hand ◽  
Australian Wool ◽  
Nematospiroides Dubius

The establishment of N. dubius juveniles was more successful in mice maintained on a diet inadequate to support the full growth potential of the animals than in mice maintained on an adequate diet. The distribution of encysted juveniles along the duodenum was considerably more extensive in the former group of mice.More juveniles were established in male than in female mice within the respective dietary groups, although the pattern of distribution was similar.The distribution of adult nematodes at 10 days after infection was confined to a smaller area of the duodenum than that of the encysted juveniles at 5 days.The differences in distribution of nematodes after 5 and 10 days between the HP and LP mice was not evident after 21 days. The survival of adult nematodes in the HP mice was more successful than in the LP animals.The female nematodes in the LP mice achieved a greater length but were less prolific egg producers than those in the HP mice.A diet inadequate to support the full growth potential of mice was therefore associated with the increased ability of Nematospiroides dubius juveniles to establish themselves in mice compared with the situation in adequately fed animals. The low plane diet, on the other hand, was associated with a decreased ability of the adult nematodes to survive.This work was supported by grants from the Commonwealth Scholarship and Fellowship Plan and the Australian Wool Board. I should like to express my appreciation for the supervision of this work by Professor J. F. A. Sprent and to thank Miss Sharon McFeeter and Mrs Anne McKeown for their most competent technical assistance.

Certain aspects of the host-parasite relationship ofNematospiroides dubius(Baylis). II. The effect of sex on experimental infections in the rat (an abnormal host)

Parasitology ◽  
1961 ◽  
Vol 51 (3-4) ◽  
pp. 499-510 ◽  
Author(s):  
Colin Dobson
Keyword(s):  
Male Rats ◽  
Male Rat ◽  
Normal Male ◽  
Female Rat ◽  
Castrate Male ◽  
Parasite Relationship ◽  
Nematospiroides Dubius ◽  
Resistance To Infection ◽  
Host Parasite ◽  
The Relationship

1. The male rat is more susceptible to infections ofNematospiroides dubiusthan the female. As the rat grows older the resistance of the female rat to infection increases at a greater rate than that of the male.2. The course of the infection is modified by the sex of the host.3. More larvae penetrated the intestinal mucosa to encyst in the male than in the female. More larvae, however, formed cysts in the female than in the male rat by the fifth day.4. The male harboured more adult worms than the female rat, although this difference was not significant in the immature animals.5. The sex resistance of the rat toN. dubiusinfections was removed by bilateral gonadectomy. Castration decreased the susceptibility of the male rat, while spaying increased it in the female compared with the susceptibility in the respective normal hosts.6. Subsequent replacement of the homologous sex hormone in the gonadectomized rat restores the sex resistance, and may even increase it (particularly in the immature animals). Oestradiol increased the resistance of the spayed female rat, while testosterone increased the susceptibility of the castrate male rat to infection.7. Oestradiol implanted in castrate male rats increased the resistance of these hosts to a greater level than was shown in the normal male rat.8. The rat shows a marked age resistance over which the sex resistance is superimposed.9. The relationship between the sex of the host and its resistance to infection is discussed.This work was done during the tenure of a Department of Scientific and Industrial Research Studentship. My thanks are due to Dr E. T. B. Francis for his helpful and critical supervision and to Professor I. Chester Jones, in whose department the work was done, for the facilities he provided.

Stage-Specific Antigens of Nematospiroides dubius Baylis, 1926 (Nematoda: Heligmosomides)

1987 ◽  
Vol 73 (6) ◽  
pp. 1164 ◽  
Author(s):  
John H. Adams ◽  
Iain J. East ◽  
Fernando Monroy G. ◽  
Elizabeth A. Washington ◽  
Colin Dobson
Keyword(s):  
Specific Antigens ◽  
Nematospiroides Dubius

Genetic control of liability to infection with Nematospiroides dubius in mice: direct and correlated responses to selection of mice for faecal parasite egg count

Parasitology ◽  
1983 ◽  
Vol 87 (1) ◽  
pp. 113-127 ◽  
Author(s):  
P. J. Brindley ◽  
C. Dobson
Keyword(s):  
Genetic Control ◽  
Primary Infection ◽  
Genetic Correlations ◽  
Strong Positive Correlation ◽  
Correlated Responses ◽  
Antibody Titres ◽  
Refractory State ◽  
Selection Limit ◽  
Nematospiroides Dubius ◽  
Positive Correlations

SUMMARYMice selected as liable (L) and refractory (R) over 10 generations voided significantly more and less Nematospiroides dubius eggs compared with randomly mated (Rd) mice after primary infection with 100 larvae. Strong positive correlation was found between the numbers of N. dubius eggs in mouse faeces and the numbers of adult N. dubius recovered from mice culled from the R, Rd and L colonies. Selection limit based on a faecal e.p.g. was reached in the L mice after 9 generations whereas the faecal N. dubius e.p.g. voided by the R mice continued to decline throughout selection. In contrast, no change in worm numbers was found in L or R mice after 6 generations. The refractory state of the trait, liability to infection with N. dubius, was inherited as a dominant character with a realized heritability value of ~ 0∣2. Differential correlated responses from N. dubius infectivity compared with N. dubius fecundity and growth indicated murine genetic control of this trait by 2 major genetic units. In general, there were negative phenotypic and genetic correlations between the faecal N. dubius e.p.g. of mice and murine morphological conformation, but positive correlations between the faecal N. dubius e.p.g. of selected mice and establishment, growth and fecundity of N. dubius populations in these mice. There was little correlation between the faecal N. dubius e.p.g. after primary infection and anti-N. dubius antibody titres and parasite female/male sex-ratio.

Certain aspects of the host-parasite relationship of Nematospiroides dubius (Baylis). I. Resistance of male and female mice to experimental infections

Parasitology ◽  
1961 ◽  
Vol 51 (1-2) ◽  
pp. 173-179 ◽  
Author(s):  
Colin Dobson
Keyword(s):  
Relative Length ◽  
Industrial Research ◽  
Male Mice ◽  
Male And Female ◽  
Female Mice ◽  
Host Parasite Relationship ◽  
Parasite Relationship ◽  
Nematospiroides Dubius ◽  
Host Parasite ◽  
Relationship Of

1. It has been shown that there is a difference between the resistance of male and female mice to infection with Nematospiroides dubius.2. More parasites were harboured, during both the larval and adult parasitic phases, by male mice.3. These worms were found to occupy a similar relative length of the intestine between the stomach and the caecum in male and female mice infected for either 5 or 10 days.4. The relative length of the intestine infected on the fifth day was significantly greater than that infected on the tenth day.This investigation was carried out during the tenure of a Research Studentship from the Department of Scientific and Industrial Research. I should like to thank Professor I. Chester Jones, in whose department the work was done, for the facilities provided and Dr E. T. B. Francis for his helpful and critical supervision.

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