Association of a single-nucleotide polymorphism in the promoter region of leukemia inhibitory factor receptor gene with low bone mineral density in adult women

Among multiple factors influencing osteoporosis,genetic variations involved in bone-mineralmetabolism can affect risks predisposing to the diseaseonset. Here, we studied single-nucleotide polymorphisms(SNPs) in the pro-opiomelanocortin (POMC)gene for possible association with bone mineral density(BMD) among 384 adult Japanese women and observedsignificant correlation between adjusted BMD and threeSNPs in the promoter region (r>0.14, p<0.01). Themost significant correlation was observed for ?2353G/A(r=?0.16, p=0.002); homozygous carriers of the major(G) allele had the highest BMD (0.405±0.054 g/cm2)while heterozygous carriers were intermediate(0.390±0.053 g/cm2) and homozygous A-allele carriershad the lowest BMDs (0.369±0.048 g/cm2). Althoughno association was detected between these SNPs andbody weight or body mass index (BMI), significantassociation was detected between the ?2313A/C genotypeand plasma total cholesterol level (r=?0.12,p=0.019). We propose that POMC is among the likelysusceptibility genes for osteoporosis and may also beinvolved in dyslipidemia.

Download Full-text

A functional single nucleotide polymorphism in the vitamin-K-dependent gamma-glutamyl carboxylase gene (Arg325Gln) is associated with bone mineral density in elderly Japanese women

Bone ◽

10.1016/j.bone.2006.08.007 ◽

2007 ◽

Vol 40 (2) ◽

pp. 451-456 ◽

Cited By ~ 30

Author(s):

Hiroyuki Kinoshita ◽

Kimie Nakagawa ◽

Ken'ichiro Narusawa ◽

Masae Goseki-Sone ◽

Mariko Fukushi-Irie ◽

...

Keyword(s):

Bone Mineral Density ◽

Single Nucleotide Polymorphism ◽

Bone Mineral ◽

Vitamin K ◽

Nucleotide Polymorphism ◽

Mineral Density ◽

Single Nucleotide ◽

Elderly Japanese Women ◽

Functional Single Nucleotide Polymorphism ◽

Elderly Japanese

Download Full-text

Association of a single nucleotide polymorphism in Wnt10bgene with bone mineral density

Geriatrics and Gerontology International ◽

10.1111/j.1447-0594.2007.00368.x ◽

2007 ◽

Vol 7 (1) ◽

pp. 48-53 ◽

Cited By ~ 3

Author(s):

Takahiko Usui ◽

Tomohiko Urano ◽

Masataka Shiraki ◽

Yasuyoshi Ouchi ◽

Satoshi Inoue

Keyword(s):

Bone Mineral Density ◽

Single Nucleotide Polymorphism ◽

Bone Mineral ◽

Nucleotide Polymorphism ◽

Mineral Density ◽

Single Nucleotide

Download Full-text

Relationship Between GIP Receptor Gene Polymorphism rs10423928 and Bone Mineral Density in Postmenopausal Women in Shanghai

10.21203/rs.3.rs-123626/v1 ◽

2020 ◽

Author(s):

Lizhi Zhang ◽

Jinwei He ◽

Xiang Sun ◽

Dongyue Pang ◽

Jingjing Hu ◽

...

Keyword(s):

Bone Mineral Density ◽

Postmenopausal Women ◽

Bone Mineral ◽

Receptor Gene ◽

Nucleotide Polymorphism ◽

Mineral Density ◽

Single Nucleotide ◽

Receptor Gene Polymorphism ◽

Insulinotropic Peptide ◽

The Relationship

Abstract Background: GIP (glucose-dependent insulinotropic peptide) has been found to affect bone metabolism. GIPR single nucleotide polymorphism (SNP) is related to its activity, but the relationship between GIPR SNP and osteoporosis in postmenopausal women is still unclear. The Aim of this study was to investigate the association between GIPR SNP and bone mineral density (BMD) in postmenopausal women in Shanghai.Methods: GIP SNP rs10423928 was detected in 884 postmenopausal women in Shanghai. The correlation between GIPR SNP and BMD was further assessed.Results: There was a statistical difference between the dominant model of this site rs10423928 and the bone mineral density of the femoral neck (P = 0.035) and the Wards triangle area (P = 0.033). Conclusions: The rs10423928 of GIPR is related to the BMD of postmenopausal women in Shanghai, China.

Download Full-text