The effect of a synthetic ceramide-2 on transepidermal water loss after stripping or sodium lauryl sulfate treatment: anin vivostudy

Natural mixtures based on bioflavonoids, terpenoids, glycosidic compounds, polyphenols, anthocyanins and essential fatty acids are often more effective and non-toxic than many synthetic drugs. Betulin, a terpene compound with many key-roles in alternative medicine, is almost insoluble in water due to its pentacyclic structure. Different drug carriers are developed to improve the drug efficacy and release. This paper described the evolution of some skin parameters (transepidermal water loss, erythema and stratum corneum hydration) after a short and respectively a long exposure to a polyurethane carrier with and without betulin using sodium lauryl sulfate as reference. It was found that these compounds are safe for human use and the hydratant effect of betulin was reconfirmed.

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The examination of biophysical parameters of skin (transepidermal water loss, skin hydration and pH value) in different body regions of ponies

Polish Journal of Veterinary Sciences ◽

10.2478/v10181-012-0081-8 ◽

2012 ◽

Vol 15 (3) ◽

pp. 553-559 ◽

Cited By ~ 4

Author(s):

M.P. Szczepanik ◽

P.M. Wilkołek ◽

M. Pluta ◽

Ł.R. Adamek ◽

Z.J.H. Pomorski

Keyword(s):

Water Loss ◽

Ph Value ◽

Neck Region ◽

Transepidermal Water Loss ◽

Skin Hydration ◽

Lumbar Region ◽

Biophysical Parameters ◽

Body Regions ◽

Skin Ph

Abstract The purpose of this study was to evaluate transepidermal water loss, skin hydration and skin pH in normal ponies. Sixteen ponies of both sexes were examined in the study. Measurements were taken from seven different sites: the neck region, the shoulder, thorax, lumbar, inguinal, lip region and the auricle. In each of the regions transepidermal water loss (TEWL), skin hydration and skin pH were measured. For transepidermal water loss, the lowest values were observed in the lumbar region (9.71g/hm2), while the highest values were observed in the lip region (22.35 g/hm2). In the case of skin hydration the lowest values were observed for the thorax region (2.13 CU), and the highest for the lip region (41.81 CU). For skin pH, the lowest results were obtained in the lumbar region (6.93), and the highest in the lip region (7.96).

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Faculty Opinions recommendation of Influence of Aqueous Cream BP on corneocyte size, maturity, skin protease activity, protein content and transepidermal water loss.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.12354956.13544054 ◽

2011 ◽

Author(s):

Joyce Lee ◽

Lucinda Tan

Keyword(s):

Protein Content ◽

Water Loss ◽

Protease Activity ◽

Transepidermal Water Loss

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ASSESSMENT OF THE TOXICITY AND HAZARD OF SODIUM LAURYL SULFATE AT DIFFERENT EXPOSURE ROUTES

Токсикологический вестник ◽

10.36946/0869-7922-2020-4-56-59 ◽

2020 ◽

pp. 56-59

Author(s):

M. V. Bidevkina ◽

M. I. Golubeva ◽

A. V. Limantsev ◽

I. N. Razumnaya ◽

T. N. Potapova ◽

...

Keyword(s):

Sodium Lauryl Sulfate ◽

Exposure Level ◽

Hazardous Substance ◽

Lauryl Sulfate ◽

Upper Respiratory Tract ◽

Mucous Membranes ◽

Chloroprene Rubber ◽

Upper Respiratory ◽

Exposure Routes ◽

Number Of Cells

Sodium lauryl sulfate is the most common surfactant used in the production of detergents, chloroprene rubber, plastics, artificial furs and in pharmaceutical industry. Sodium lauryl sulfate is a moderately hazardous substance when introduced into the stomach (DL50 for white mice and rats is in the range of 2086-2700 mg/kg), has a pronounced local irritant effect on the skin and mucous membranes of the eyes, has a skin-resorptive, sensitizing and pronounced cumulative effects. The threshold for acute inhalation action is set at 15,3 mg/m3 for changes in the function of the nervous system and irritating effects on the mucous membranes of the upper respiratory tract (an increase in the total number of cells in the nasal flushes).Recommended for approval tentative safe exposure level of sodium lauryl sulfate in the air of the working area is 0.2+ mg/m3 (aerosol).

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