Cerebrospinal Fluid and Serum Neuron-Specific Enolase in Acute Benign Headache

We determined the cerebrospinal fluid (CSF) and serum neuron-specific enolase (NSE) concentrations in 19 patients with acute benign headache. All patients had normal neurological examination, CSF and head computed tomography scan. The final diagnoses were: primary thunderclap headache ( n = 7), primary exertional headache ( n = 3), primary cough headache ( n = 1), migraine without aura ( n = 4), headache unspecified ( n = 2), probable infrequent episodic tension-type headache ( n = 1), headache attributed to hypertensive crisis without hypertensive encephalopathy ( n = 1). A group of 108 healthy subjects served as controls. CSF NSE concentration was 14.16 ng/ml [95% confidence interval (CI) 11.86, 16.47)] in the headache sample (controls 17.19 ng/ml, 95% CI 16.23, 18.15). Serum NSE concentration was 7.50 ng/ml (95% CI 5.20, 9.80) in the headache sample (controls 8.45 ng/ml, 95% CI 7.67, 9.23). CSF/serum ratio was 2.81 (95% CI 2.21, 3.40) in the headache sample (controls 2.23, 95% CI 2.03, 2.42). Acute benign headache is not associated with neuronal damage as estimated by means of CSF and serum NSE concentration.

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Serum Levels of Neuron-Specific Enolase in Children With Diabetic Ketoacidosis

Journal of Child Neurology ◽

10.1177/0883073816686718 ◽

2017 ◽

Vol 32 (5) ◽

pp. 475-481 ◽

Cited By ~ 3

Author(s):

Sherifa Hamed ◽

Kotb Abbass Metwalley ◽

Hekma Saad Farghaly ◽

Tahra Sherief

Keyword(s):

Diabetic Ketoacidosis ◽

Neuronal Damage ◽

Neuron Specific Enolase ◽

Serum Levels ◽

Time Points ◽

Factors Associated ◽

Neurologic Disorders ◽

Younger Age ◽

Serum Neuron Specific Enolase ◽

Sensitive Marker

Neuron-specific enolase is a sensitive marker of neuronal damage in various neurologic disorders. This study aimed to measure serum neuron-specific enolase levels at different time points and severities of diabetic ketoacidosis. This study included 90 children (age 9.2 ± 3.4 years) with diabetic ketoacidosis. Neuron-specific enolase was measured at 3 time points (baseline and after 12 and 24 hours of starting treatment). Among patients, 74.4% had diagnosis of new diabetes, 60% had Glasgow Coma Scale score <15, and 75.6% had moderate/severe diabetic ketoacidosis. Compared with controls (n = 30), children with diabetic ketoacidosis had higher neuron-specific enolase levels at the 3 time points ( P = .0001). In multiple regression analysis, the factors associated with higher neuron-specific enolase levels were younger age, higher glucose, lower pH, and bicarbonate values. This study indicates that serum neuron-specific enolase is elevated in diabetic ketoacidosis and correlated with the severity of hyperglycemia, ketosis, and acidosis. This study indicates that diabetic ketoacidosis may cause neuronal injury from which the patients recovered partially but not completely.

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Neuron-specific enolase in cerebrospinal fluid: A possible indicator of neuronal damage in kainic acid lesions

Neuroscience Letters ◽

10.1016/0304-3940(84)90090-9 ◽

1984 ◽

Vol 45 (2) ◽

pp. 147-150 ◽

Cited By ~ 10

Author(s):

R. Steinberg ◽

H. Scarna ◽

J.F. Pujol

Keyword(s):

Cerebrospinal Fluid ◽

Kainic Acid ◽

Neuronal Damage ◽

Neuron Specific Enolase

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Cerebrospinal fluid and serum neuron-specific enolase concentrations in a normal population*

European Journal of Neurology ◽

10.1111/j.1468-1331.2004.01021.x ◽

2005 ◽

Vol 12 (5) ◽

pp. 369-374 ◽

Cited By ~ 39

Author(s):

M. Casmiro ◽

S. Maitan ◽

F. De Pasquale ◽

V. Cova ◽

E. Scarpa ◽

...

Keyword(s):

Cerebrospinal Fluid ◽

Normal Population ◽

Neuron Specific Enolase ◽

Serum Neuron Specific Enolase

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Prediction of regaining consciousness despite an early epileptiform EEG after cardiac arrest

Neurology ◽

10.1212/wnl.0000000000009283 ◽

2020 ◽

Vol 94 (16) ◽

pp. e1675-e1683 ◽

Cited By ~ 3

Author(s):

Giuseppina Barbella ◽

Jong Woo Lee ◽

Vincent Alvarez ◽

Jan Novy ◽

Mauro Oddo ◽

...

Keyword(s):

Cardiac Arrest ◽

Operating Characteristic ◽

Neuronal Damage ◽

Cerebral Performance Category ◽

Neuron Specific Enolase ◽

Area Under The Curve ◽

Performance Category ◽

Receiver Operating Characteristic Curves ◽

Normal Background ◽

Serum Neuron Specific Enolase

ObjectiveAfter cardiac arrest (CA), epileptiform EEG, occurring in about 1/3 of patients, often but not invariably heralds poor prognosis. We tested the hypothesis that a combination of specific EEG features identifies patients who may regain consciousness despite early epileptiform patterns.MethodsWe retrospectively analyzed a registry of comatose patients post-CA (2 Swiss centers), including those with epileptiform EEG. Background and epileptiform features in EEGs 12–36 hours or 36–72 hours from CA were scored according to the American Clinical Neurophysiology Society nomenclature. Best Cerebral Performance Category (CPC) score within 3 months (CPC 1–3 vs 4–5) was the primary outcome. Significant EEG variables were combined in a score assessed with receiver operating characteristic curves, and independently validated in a US cohort; its correlation with serum neuron-specific enolase (NSE) was also tested.ResultsOf 488 patients, 107 (21.9%) had epileptiform EEG <72 hours; 18 (17%) reached CPC 1–3. EEG 12–36 hours background continuity ≥50%, absence of epileptiform abnormalities (p < 0.00001 each), 12–36 and 36–72 hours reactivity (p < 0.0001 each), 36–72 hours normal background amplitude (p = 0.0004), and stimulus-induced discharges (p = 0.0001) correlated with favorable outcome. The combined 6-point score cutoff ≥2 was 100% sensitive (95% confidence interval [CI], 78%–100%) and 70% specific (95% CI, 59%–80%) for CPC 1–3 (area under the curve [AUC], 0.98; 95% CI, 0.94–1.00). Increasing score correlated with NSE (ρ = −0.46, p = 0.0001). In the validation cohort (41 patients), the score was 100% sensitive (95% CI, 60%–100%) and 88% specific (95% CI, 73%–97%) for CPC 1–3 (AUC, 0.96; 95% CI, 0.91–1.00).ConclusionPrognostic value of early epileptiform EEG after CA can be estimated combining timing, continuity, reactivity, and amplitude features in a score that correlates with neuronal damage.

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Cerebrospinal Fluid and Serum Neuron-Specific Enolase Levels After Febrile Seizures

Epilepsia ◽

10.1046/j.1528-1157.2001.30100.x ◽

2001 ◽

Vol 42 (4) ◽

pp. 504-507 ◽

Cited By ~ 20

Author(s):

Takuya Tanabe ◽

Shuhei Suzuki ◽

Keita Hara ◽

Shuiti Shimakawa ◽

Eiji Wakamiya ◽

...

Keyword(s):

Cerebrospinal Fluid ◽

Neuron Specific Enolase ◽

Febrile Seizures ◽

Serum Neuron Specific Enolase

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Cerebrospinal Fluid Cytokine Levels in Migraine, Tension-Type Headache and Cervicogenic Headache

Cephalalgia ◽

10.1111/j.1468-2982.2008.01727.x ◽

2009 ◽

Vol 29 (3) ◽

pp. 365-372 ◽

Cited By ~ 47

Author(s):

SH Bø ◽

EM Davidsen ◽

P Gulbrandsen ◽

E Dietrichs ◽

G Bovim ◽

...

Keyword(s):

Cerebrospinal Fluid ◽

Migraine With Aura ◽

Transforming Growth Factor ◽

Cervicogenic Headache ◽

Tension Type Headache ◽

Significant Group ◽

Significant Difference ◽

Cytokine Levels ◽

Type Headache ◽

Tgf Β1

Cytokines have been measured in cerebrospinal fluid (CSF) from headache patients [infrequent episodic tension-type headache (TTH) and migraine with or without aura, all during attack, and cervicogenic headache] and compared with levels in pain-free individuals. Both proinflammatory [interleukin (IL)-1β, tumour necrosis factor-α and monocyte chemoattractant protein-1 (MCP-1)] and anti-inflammatory cytokines IL-1 receptor antagonist (IL-1ra), IL-4, IL-10 and transforming growth factor-β1 (TGF-β1)] were included. There were significant group differences in IL-1ra, TGF-β1 and MCP-1 in episodic TTH and migraine compared with controls, and a significant difference in MCP-1 between cervicogenic headache and migraine with aura. Intrathecal MCP-1 correlated with IL-1ra, IL-10 and TGF-β1 in episodic TTH, and MCP-1 with IL-10 in migraine with aura. Cytokine increases were modest compared with those often accompanying serious neurological conditions, and may represent a mild response to pain. We believe this to be the first comparative study of CSF cytokine levels in connection with headache.

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