Neuron-specific enolase in cerebrospinal fluid: A possible indicator of neuronal damage in kainic acid lesions

We determined the cerebrospinal fluid (CSF) and serum neuron-specific enolase (NSE) concentrations in 19 patients with acute benign headache. All patients had normal neurological examination, CSF and head computed tomography scan. The final diagnoses were: primary thunderclap headache ( n = 7), primary exertional headache ( n = 3), primary cough headache ( n = 1), migraine without aura ( n = 4), headache unspecified ( n = 2), probable infrequent episodic tension-type headache ( n = 1), headache attributed to hypertensive crisis without hypertensive encephalopathy ( n = 1). A group of 108 healthy subjects served as controls. CSF NSE concentration was 14.16 ng/ml [95% confidence interval (CI) 11.86, 16.47)] in the headache sample (controls 17.19 ng/ml, 95% CI 16.23, 18.15). Serum NSE concentration was 7.50 ng/ml (95% CI 5.20, 9.80) in the headache sample (controls 8.45 ng/ml, 95% CI 7.67, 9.23). CSF/serum ratio was 2.81 (95% CI 2.21, 3.40) in the headache sample (controls 2.23, 95% CI 2.03, 2.42). Acute benign headache is not associated with neuronal damage as estimated by means of CSF and serum NSE concentration.

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The increase of neuron-specific enolase in cerebrospinal fluid and plasma as a marker of neuronal damage in patients with acute brain infarction

Journal of Clinical Neuroscience ◽

10.1016/j.jocn.2004.07.019 ◽

2005 ◽

Vol 12 (5) ◽

pp. 542-547 ◽

Cited By ~ 38

Author(s):

V. Selakovic ◽

R. Raicevic ◽

L. Radenovic

Keyword(s):

Cerebrospinal Fluid ◽

Neuronal Damage ◽

Brain Infarction ◽

Neuron Specific Enolase

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Experimental Brain Ischemia: Neuron-Specific Enolase Level in Cerebrospinal Fluid as an Index of Neuronal Damage

Journal of Neurochemistry ◽

10.1111/j.1471-4159.1984.tb06673.x ◽

1984 ◽

Vol 43 (1) ◽

pp. 19-24 ◽

Cited By ~ 68

Author(s):

R. Steinberg ◽

C. Gueniau ◽

H. Scarna ◽

A. Keller ◽

M. Worcel ◽

...

Keyword(s):

Cerebrospinal Fluid ◽

Brain Ischemia ◽

Neuronal Damage ◽

Neuron Specific Enolase

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Value of NSE and S100 Protein of Kawasaki Disease with aseptic meningitis in Infant

Open Life Sciences ◽

10.1515/biol-2019-0040 ◽

2019 ◽

Vol 14 (1) ◽

pp. 358-362

Author(s):

Jiangtao Wang ◽

Shouhang Chen ◽

Xiaoling Wang ◽

Huiru Gu ◽

Junli Liu ◽

...

Keyword(s):

Cerebrospinal Fluid ◽

Kawasaki Disease ◽

Aseptic Meningitis ◽

Neuronal Damage ◽

S100 Protein ◽

Neuron Specific Enolase ◽

Area Under The Curve ◽

Control Group ◽

Purulent Meningitis ◽

And Control

AbstractThe cerebrospinal fluid content was examined for concentrations of S100 protein and neuron-specific enolase (NSE) in two diseases, Kawasaki disease (KD) with aseptic meningitis (1-3 months) and purulent meningitis (PM), to determine whether or not these measuremets could be used in early diagnosis. The content of cerebrospinal fluid S100 protein of KD with aseptic meningitis and PM were significantly higher than those in the control group. There was also a difference between KD and purulent meningitis (PM). The concentration of NSE was highest in the encephalitis group, which was statistically different from control group. However, there was no difference between the KD and control groups. The levels of S100 protein and NSE of KD with aseptic meningitis were lower than those in PM, indicating that the extent of neuronal damage is significantly lower than of the enchephalitis group. The area under the curve (AUCs) of the receiver operating characteristic (ROC) curve for S100 and NSE were both 0.972. The S100 threshold was 0.4315, the sensitivity was 92.1%, and the specificity was 100%, while the NSE threshold was 9.325, sensitivity 92.1%, and specificity 90%. The combined detection of NSE and S100 levels in the cerebrospinal fluid can be used for the differential diagnosis of KD with aseptic meningitis and purulent meningitis.

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Faculty Opinions recommendation of Blood brain barrier impairment is associated with cerebrospinal fluid markers of neuronal damage in HIV-positive patients.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726110713.793529619 ◽

2017 ◽

Author(s):

Bruce Brew

Keyword(s):

Cerebrospinal Fluid ◽

Blood Brain Barrier ◽

Neuronal Damage ◽

Brain Barrier ◽

Hiv Positive ◽

Blood Brain

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Serum Endocan, Neuron-Specific Enolase and Ischemia-Modified Albumin Levels in Newborns with Partial Blood Exchange Transfusion

Combinatorial Chemistry & High Throughput Screening ◽

10.2174/1386207323999200820163525 ◽

2020 ◽

Vol 23 ◽

Author(s):

Erbu Yarci ◽

Cuneyt Tayman ◽

Ufuk Cakir ◽

Utku Serkant

Keyword(s):

Exchange Transfusion ◽

Neuronal Damage ◽

Neuron Specific Enolase ◽

Endothelial Damage ◽

Control Group ◽

Control Groups ◽

Term Neonates ◽

Blood Exchange ◽

Blood Exchange Transfusion ◽

And Control

Background:: Hyperviscosity of blood secondary to polycythemia results in increased resistance to blood flow and decrease in delivery of oxygen. Objective:: To evaluate whether serum endocan, NSE and IMA levels can be compared in terms of endothelial injury/ dysfunction and neuronal damage in term neonates with polycythemia who underwent PET. Methods:: 38 symptomatic polycythemic newborns having PET and 38 healthy newborns were included in the study. Blood samples for endocan, NSE and IMA were taken at only postnatal 24 hours of age in the control group and in polycytemia group just before PET, at 24 and 72 hours after PET. Results:: The polycythemia group had higher serum endocan(1073,4 ± 644,8 vs. 378,8 ± 95,9ng/ml; p<0.05), IMA(1,32 ± 0,34 vs.0,601 ± 0,095absorbance unit; p<0.05) and NSE(44,7 ± 4,3 vs. 26,91 ± 7,12μg/l; p<0.05) levels than control group before the PET procedure. At 24 hours after PET, IMA(0,656 ± 0,07 vs. 0,601 ± 0,095absorbance unit; p<0.05) and endocan(510,9 ± 228,6 vs. 378,8 ± 95,9ng/ml; p<0.05) levels were closer to the control group, being still statistically significant higher. NSE levels decreased to control group levels having no difference between the PET and control groups at 24 hours after PET (28,98 ± 6,5 vs. 26,91 ± 7,12μg/l; p>0.05). At 72 hours after PET the polycythemia and control groups did not differ statistically for IMA, endocan and NSE levels (p>0.05). Conclusion:: Serum endocan and IMA levels can be used as a biomarker for endothelial damage / dysfunction and tissue hypoxia in infants with symptomatic polycytemia.

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Comparison of Prognostic Performance between Neuron-Specific Enolase and S100 Calcium-Binding Protein B Obtained from the Cerebrospinal Fluid of Out-Of-Hospital Cardiac Arrest Survivors Who Underwent Targeted Temperature Management

Journal of Clinical Medicine ◽

10.3390/jcm10071531 ◽

2021 ◽

Vol 10 (7) ◽

pp. 1531

Author(s):

Changshin Kang ◽

Wonjoon Jeong ◽

Jung Soo Park ◽

Yeonho You ◽

Jin Hong Min ◽

...

Keyword(s):

Cerebrospinal Fluid ◽

Cardiac Arrest ◽

Calcium Binding ◽

Neuron Specific Enolase ◽

Poor Outcome ◽

The Poor ◽

S100 Calcium Binding Protein ◽

Poor Outcome Group ◽

Outcome Group ◽

Hospital Cardiac Arrest

We compared the prognostic performances of serum neuron-specific enolase (sNSE), cerebrospinal fluid (CSF) NSE (cNSE), and CSF S100 calcium-binding protein B (cS100B) in out-of-hospital cardiac arrest (OHCA) survivors. This prospective observational study enrolled 45 patients. All samples were obtained immediately and at 24 h intervals until 72 h after the return of spontaneous circulation. The inter- and intragroup differences in biomarker levels, categorized by 3 month neurological outcome, were analyzed. The prognostic performances were evaluated with receiver operating characteristic curves. Twenty-two patients (48.9%) showed poor outcome. At all-time points, sNSE, cNSE, and cS100B were significantly higher in the poor outcome group than in the good outcome group. cNSE and cS100B significantly increased over time (baseline vs. 24, 48, and 72 h) in the poor outcome group than in the good outcome group. sNSE at 24, 48, and 72 h showed significantly lower sensitivity than cNSE or cS100B. The sensitivities associated with 0 false-positive rate (FPR) for cNSE and cS100B were 66.6% vs. 45.5% at baseline, 80.0% vs. 80.0% at 24 h, 84.2% vs. 94.7% at 48 h, and 88.2% (FPR, 5.0%) vs. 94.1% at 72 h. High cNSE and cS100B are strong predictors of poor neurological outcome in OHCA survivors. Multicenter prospective studies may determine the generalizability of these results.

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