scholarly journals Estimating genetic and non-genetic components of variance for fasting glucose levels in pedigrees ascertained through non-insulin dependent diabetes

1982 ◽  
Vol 46 (4) ◽  
pp. 355-362 ◽  
Author(s):  
T. H. BEATY ◽  
S. S. FAJANS
Molecules ◽  
2019 ◽  
Vol 24 (24) ◽  
pp. 4474
Author(s):  
Kyeong-Mi Choi ◽  
Hwan-Soo Yoo

Type 1 diabetes mellitus (insulin-dependent diabetes) is characterized by hyperglycemia caused by an insulin deficiency. Diabetic nephropathy is a major complication of hyperglycemia. 3,3′-diindolylmethane (DIM)-a natural compound produced from indole-3-carbinol, found in cruciferous vegetables-enhances glucose uptake by increasing the activation of the insulin signaling pathway in 3T3-L1 adipocytes. In this study, we investigated whether DIM could improve insulin-dependent diabetes and nephropathy in streptozotocin (STZ)-induced diabetic mice. In mice, STZ induced hyperglycemia, hunger, thirst, and abnormally increased kidney weight and serum creatinine, which is a renal functional parameter. DIM decreased STZ-increased high blood glucose levels and food and water intake in diabetic mice. DIM also improved diabetic nephropathy by inhibiting the expression of PKC-α, the marker of albuminuria, and TGF-β1, an indicator of renal hypertrophy, in diabetic mice. Our findings suggest that DIM may ameliorate hyperglycemia and diabetic nephropathy through the inhibition of PKC-α and TGF-β1 signaling.


2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Yu-Chen Lee ◽  
Te-Mao Li ◽  
Chung-Yuh Tzeng ◽  
Ying-I Chen ◽  
Wai-Jane Ho ◽  
...  

Animal studies have shown that electroacupuncture (EA) at Zusanli (ST-36) and Zhongwan (CV-12) acupoints reduces plasma glucose concentrations in rats with type II diabetes. However, whether EA reduces plasma glucose levels in type I diabetes is still unknown. In this study, we explore the various non-insulin-dependent pathways involved in EA-induced lowering of plasma glucose. Streptozotocin (STZ) (60 mg kg−1, i.v.) was administered via the femoral vein to induce insulin-dependent diabetes in non-adrenalectomized and in adrenalectomomized rats. EA (15 Hz) was applied for 30 min to bilateral ST-36 acupoints after administration of Atropine (0.1 mg kg−1i.p.), Eserine (0.01 mg kg−1i.p.), or Hemicholinium-3 (5 μg kg−1i.p.) in non-adrenalectomized rats. Rats administered acetylcholine (0.01 mg kg−1i.v.) did not undergo EA. Adrenalectomized rats underwent EA at bilateral ST-36 acupoints without further treatment. Blood samples were drawn from all rats before and after EA to measure changes in plasma glucose levels. Expression of insulin signaling proteins (IRS1, AKT2) in atropine-exposed rats before and after EA was measured by western blot. Atropine and hemicholinium-3 completely blocked the plasma glucose lowering effects of EA, whereas eserine led to a significant hypoglycemic response. In addition, plasma glucose levels after administration of acetylcholine were significantly lower than the fasting glucose levels. In STZ-adrenalectomized rats, EA did not induce a hypoglycemic response. EA stimulated the expression of IRS1 and AKT2 and atropine treatment blocked the EA-induced expression of those insulin signaling proteins. Taken together, EA at the ST-36 acupoint reduces plasma glucose concentrations by stimulating the cholinergic nerves.


1987 ◽  
Vol 9 (5) ◽  
pp. 155-162
Author(s):  
John W. Reynolds

1. All foods should be labeled to indicate the calories, sources of the calories, the mineral and vitamin content, the types and amounts of carbohydrates, the amount of cholesterol and amounts and types of fatty acids, and the amount and type of artificial sweetener, if any. 2. A long-term evaluation of the exchange system in the dietary instruction of patients with insulin-depedent diabetes mellitus and their families should be carried out. 3. General guidelines for meal plans for youngsters with diabetes should allow for flexibility and variety in food selection so that they account for individual differences as well as being applicable to different socio-economic, cultural, and ethnic groups. 4. The distribution of calories in the diet should be: 50% to 60% carbohydrate, 15% to 20% protein, and 20% to 25% fat. 5. Nutrition education of the patient with insulin-dependent diabetes mellitus and of the patient's family about the principles of good nutrition, the importance of a balanced meal plan, and the rationale for food prohibitions should be a critical part of diabetes care. 6. Nutritional assessment should include plotting height and weight measurements on standard growth grids at regular intervals. 7. Scientifically sound cross-over studies of the differences between "simple" and "complex" carbohydrates need to be carried out on children with insulin-dependent diabetes mellitus. 8. Before optimal and safe use of fiber in therapy of children is possible, further studies are needed of the convenience and palatability of meals with currently available fiber, the use of "medicated foods" to which specific types of fiber have been added, and the extent of trace element and mineral binding by various fibers. 9. More studies are needed concerning the effects of food form, nutrient-nutrient interactions, and non-nutritive constituents of food on the glycemic effect of a given food. 10. Fructose and sorbitol may be used in limited amounts as parts of an otherwise nutritious and well-balanced meal plan, but the usefulness of their chronic ingestion has not been established. 11. Fructose and sorbitol are not substitutes for artificial noncaloric sweeteners and should not be used in the belief that they are of use in weight control. 12. Aspartame contains no calories and has no apparent risks. However, consumption of large amounts of granulated aspartame, which contains a lactose or dextrose carrier, could affect blood glucose levels. The use of cyclamate and saccharin by children with insulin-dependent diabetes mellitus should be limited pending further review. 13. The use of combinations of artificial sweeteners is reasonable to limit the risks associated with any one sweetener. 14. The medical profession and patients with insulin-dependent diabetes mellitus should be made aware that the disease is a disorder of lipid metabolism as well as carbohydrate metabolism. 15. Cholesterol and saturated fat intake should be limited and the total calories from fat should be reduced to 20% to 25% of the caloric intake. 16. Patients with insulin-dependent diabetes mellitus should have at least yearly monitoring of their fasting serum total and high-density lipoprotein cholesterol levels and the triglyceride levels. 17. The patient with insulin-dependent diabetes mellitus should be taught that, in addition to control of the dietary lipid intake, limitation of the high rate of cardiovascular complications associated with insulin-dependent diabetes mellitus depends on excellent control of blood glucose levels, age-appropriate aerobic exercise, and avoidance of the use of tobacco in any form. 18. Blood pressure should be monitored every 6 to 12 months. It is critical that hypertension be diagnosed and treated early. 19. Young patients with insulin-dependent diabetes mellitus, and their families, should be educated in a prudent approach to the use of dietary salt, with little use of added salt and a choice of foods without excessive sodium content. However, supplemental sodium chloride may be warranted when there is glycosuria in a newly diagnosed or poorly controlled patient. 20. Insulin-dependent diabetes mellitus does not result in increased dietary requirements for iron, magnesium, zinc, selenium, chromium, or other trace minerals or vitamins and, therefore, should not be an indication per se for mineral or vitamin supplements. 21. Nutritionists and dietitians with expertise in the treatment of childhood and adolescent diabetes should be recognized as valuable members of a multidisciplinary diabetes health care team. The role of such a nutritionist or dietitian includes an initial assessment and then later adjustment of meal plans to be consistent with the patient's growth, development, changes in activity level, and appearance of complications. 22. Families should be advised to follow principles of good nutrition in their own meal planning as a way to increase dietary compliance by their children with insulin-dependent diabetes mellitus. Flexibility in meal plans should be encouraged as a way to maximize dietary compliance.


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