Subtypes of Sodium-Dependent High-Affinity L-[3H]Glutamate Transport Activity: Pharmacologic Specificity and Regulation by Sodium and Potassium

1993 ◽  
Vol 60 (1) ◽  
pp. 167-179 ◽  
Author(s):  
Michael B. Robinson ◽  
Jeroo D. Sinor ◽  
Lisa A. Dowd ◽  
James F. Kerwin
Keyword(s):  
Glutamate Transport ◽  
Transport Activity ◽  
High Affinity ◽  
Sodium Dependent ◽  
Sodium And Potassium

Pharmacology of Sodium-Dependent High-Affinity l-[3H]Glutamate Transport in Glial Cultures

2002 ◽  
Vol 64 (6) ◽  
pp. 2572-2580 ◽  
Author(s):  
Amy B. Garlin ◽  
Amy D. Sinor ◽  
Jeroo D. Sinor ◽  
Sandy H. Jee ◽  
Judith B. Grinspan ◽  
...  
Keyword(s):  
Glutamate Transport ◽  
High Affinity ◽  
Glial Cultures ◽  
Sodium Dependent

Regulation of high-affinity glutamate transport by amino acid deprivation and hyperosmotic stress

1999 ◽  
Vol 277 (4) ◽  
pp. F498-F500 ◽  
Author(s):  
J. D. McGivan ◽  
B. Nicholson
Keyword(s):  
Protein Synthesis ◽  
Amino Acid ◽  
Glutamate Transporter ◽  
Indirect Evidence ◽  
Glutamate Transport ◽  
Mrna Levels ◽  
Amino Acid Deprivation ◽  
Free Medium ◽  
Transport Activity ◽  
High Affinity

High-affinity glutamate transport activity is induced by stress in NBL-1 cells. Exposure of cells to hyperosmotic medium led to an induction of the EAAC1 glutamate transporter, preceded by a large increase in EAAC1 mRNA levels. Culture of cells in amino acid-free medium also caused a protein synthesis-dependent increase in glutamate transport activity, but this was not accompanied by an increase of either EAAC1 mRNA or protein. Indirect evidence suggests that the increase in EAAC1 activity in the latter case may be due to the synthesis of an activator protein in response to decreased intracellular glutamate concentrations.

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