Prevalence of and Risk Factors for Postoperative Ileus after Small Intestinal Surgery in Two Hundred and Thirty-Three Horses

Purpose: The study aimed to investigate the risk factors for postoperative ileus (POI) after small intestinal fistula excision (SIFE) in patients with diffuse extensive abdominal adhesions.Methods: From October 2010 to December 2019, we enrolled patients who underwent SIFE and had diffuse extensive abdominal adhesions. Patients were divided into the POI group and the non-POI group according to its occurrence. We then investigated and analyzed the clinical characteristics of both groups.Result: A total of 247 patients were enrolled into the study. There were 100 patients in the POI group, and 147 patients in the non-POI group. A multi-variable logistic regression analysis revealed that blood loss during SIFE (OR = 1.001; 95% CI: 1.000–1.259; P = 0.012), postoperative lactate(OR = 1.212; 95% CI: 1.001–1.304; P = 0.015), grade V abdominal adhesions (OR = 2.518; 95% CI: 1.814–3.44; P = 0.024), and time for recovery of lactate <2 mmol/L (OR = 2.079; 95% CI: 1.599–3.616; P = 0.026) were associated with POI. Moreover, POI was also associated with prolonged postoperative stay in the hospital (HR = 3.291; 95% CI: 2.511–4.172; P = 0.014).Conclusion: Blood loss during operation, grade V abdominal adhesions, positive fluid balance within 48 h of operation, and time for recovery of lactate were the risk factors for POI after SIFE in patients with diffuse extensive abdominal adhesions.

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Short- and long-term survival and prevalence of postoperative ileus after small intestinal surgery in the horse

Equine Veterinary Journal ◽

10.1111/j.2042-3306.2000.tb05333.x ◽

2010 ◽

Vol 32 (S32) ◽

pp. 42-51 ◽

Cited By ~ 99

Author(s):

D. E. FREEMAN ◽

P. HAMMOCK ◽

G. J. BAKER ◽

T. GOETZ ◽

J. H. FOREMAN ◽

...

Keyword(s):

Postoperative Ileus ◽

Intestinal Surgery ◽

Term Survival ◽

Long Term Survival ◽

Short And Long Term ◽

Small Intestinal

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RISK FACTORS AND POST‐OPERATIVE VARIABLES ASSOCIATED WITH EQUINE POST‐OPERATIVE ILEUS FOLLOWING SMALL INTESTINAL SURGERY: A STUDY OF CLINICAL RECORDS FROM THREE VETERINARY SCHOOL FACILITIES OVER A FIVE‐YEAR PERIOD (2004‐2010)

Equine Veterinary Education ◽

10.1111/eve.79_13534 ◽

2021 ◽

Vol 33 (S12) ◽

pp. 42-43

Keyword(s):

Risk Factors ◽

School Facilities ◽

Intestinal Surgery ◽

Veterinary School ◽

Small Intestinal ◽

Clinical Records

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Small Intestinal Bacterial Overgrowth Is Associated with Non- Alcoholic Fatty Liver Disease

Journal of Gastrointestinal and Liver Diseases ◽

10.15403/jgld.2014.1121.252.iwg ◽

2016 ◽

Vol 25 (2) ◽

pp. 159-165 ◽

Cited By ~ 33

Author(s):

Andrea Fialho ◽

Andre Fialho ◽

Prashanthi Thota ◽

Arthur J. McCullough ◽

Bo Shen

Keyword(s):

Risk Factors ◽

Fatty Liver Disease ◽

Bacterial Overgrowth ◽

Small Intestinal Bacterial Overgrowth ◽

Study Group ◽

Alcoholic Fatty Liver ◽

Intestinal Bacterial Overgrowth ◽

Small Intestinal ◽

Alcoholic Fatty Liver Disease

Background: Changes in gut bacteria play a role in type 2 diabetes mellitus (DM) and hepatic steatosis. There is a lack of studies evaluating the frequency and risk factors for non-alcoholic fatty liver disease (NAFLD) in patients tested for small intestinal bacterial overgrowth (SIBO). Aim: To evaluate the frequency of NAFLD and associated risk factors in patients tested for SIBO. Methods: In this case-control study, 372 eligible patients submitted to glucose hydrogen/methane breath test for SIBO who also had an abdominal imaging study were included. Patients were divided into SIBO-positive and SIBO-negative groups. Clinical, demographic and laboratory variables were evaluated in addition to the presence of NAFLD on abdominal imaging. Results: Of the 372 eligible patients, 141 (37.9%) were tested positive for SIBO (study group) and 231 (62.1%) were negative for it (control group). NAFLD occurred in 45.4% (64/141) of the study group compared to 17.3% (40/231) of the control group (p<0.001). Patients in the study group were found to have higher rates of elevated aspartate aminotransferase (AST) (20.6% vs. 11.3%; p=0.034) and alanine aminotransferase (ALT) levels (56.0% vs. 40.7%; p= 0.039), type 2 diabetes (23.4% vs. 13.9%; p=0.041), hypertension (54.6% vs. 40.3%; p=0.046) and metabolic syndrome (78.0% vs. 60.2%; p=0.020). In the multivariate analysis, SIBO (odds ratio [OR]: 1.95; 95% confidence interval [CI]: 1.14-3.31; p=0.014), type 2 DM (OR: 3.04; 95%CI: 1.57-5.90; p=0.001) and obesity (OR: 3.58; 95%CI: 1.70-7.54; p=0.001) remained associated with NAFLD.Conclusion: Patients with SIBO have an increased risk for hepatic steatosis and may benefit from aggressive control of the risk factors for NAFLD including metabolic syndrome. Abbreviations: ALT: alanine aminotransferase; AST: aspartate aminotransferase; BMI: body mass index; CTE: computed tomography enterography; DM: diabetes mellitus; ETOH: ethanol; IL: interleukin; LPS: lipopolysaccharide; NAFLD: non-alcoholic fatty liver disease; NASH: non-alcoholic steatohepatitis; PPI: proton pump inhibitor; SIBO: small intestinal bacterial overgrowth; TLR-4: toll-like receptor 4; TMAO: trimethylamine-N-oxide (TMAO); TNF-α: tumor necrosis factor alpha.

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