In vivo Effects of Mutant HERG K+Channel Inhibition by Disopyramide in Patients with a Short QT-1 Syndrome: A Pilot Study

Abstract Objective: Extracellular histones have been identified as one molecular factor that can cause and sustain alveolar damage and were linked to high mortality rates in critically ill patients. In this pilot study, we wanted to validate the proinflammatory in vivo effects of local and systemic histone application in a prospective translational porcine model. This was combined with the evaluation of an experimental acute lung injury model using intrabronchial lipopolysaccharides, which has been published previously.Results: The targeted application of histones was successful in all animals. Animals showed decreased oxygenation after instillation, but no differences could be detected between the sham and histone treatments. Additionally, intravenous histone injection had no effect. The histologic analyses and inflammatory responses indicated that there were no differences in tissue damage between the groups.

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Intrabronchial application of extracellular histones shows no proinflammatory effects in swine in a translational pilot study

BMC Research Notes ◽

10.1186/s13104-021-05704-7 ◽

2021 ◽

Vol 14 (1) ◽

Author(s):

Robert Ruemmler ◽

Alexander Ziebart ◽

Elisabeth Britten ◽

Moritz Gosling ◽

Rene Rissel ◽

...

Keyword(s):

Pilot Study ◽

Porcine Model ◽

Inflammatory Responses ◽

Mortality Rates ◽

Injury Model ◽

Molecular Factor ◽

Extracellular Histones ◽

Lung Injury Model ◽

In Vivo Effects

Abstract Objective Extracellular histones have been identified as one molecular factor that can cause and sustain alveolar damage and were linked to high mortality rates in critically ill patients. In this pilot study, we wanted to validate the proinflammatory in vivo effects of local histone application in a prospective translational porcine model. This was combined with the evaluation of an experimental acute lung injury model using intrabronchial lipopolysaccharides, which has been published previously. Results The targeted application of histones was successful in all animals. Animals showed decreased oxygenation after instillation, but no differences could be detected between the sham and histone treatments. The histologic analyses and inflammatory responses indicated that there were no differences in tissue damage between the groups.

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837 Absence of in-vivo effects of dental instruments on pacemaker function

EP Europace ◽

10.1016/s1099-5129(05)80575-6 ◽

2005 ◽

Vol 7 ◽

pp. 195-195

Keyword(s):

Dental Instruments ◽

Pacemaker Function ◽

In Vivo Effects

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In vivo effects of TGF-β1 in lung surfactant regulation, lung meachanics amd structure

Pneumologie ◽

10.1055/s-0034-1376812 ◽

2014 ◽

Vol 68 (06) ◽

Author(s):

E Lopez-Rodriguez ◽

C Boden ◽

S Knippenberg ◽

A Pascual ◽

J Perez-Gil ◽

...

Keyword(s):

Lung Surfactant ◽

In Vivo Effects ◽

Tgf Β1

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Evaluation of Sacroiliac Wedge Rotation to Increase Acetabular Ventroversion

Veterinary and Comparative Orthopaedics and Traumatology ◽

10.1055/s-0038-1632486 ◽

1999 ◽

Vol 12 (04) ◽

pp. 173-177 ◽

Cited By ~ 2

Author(s):

R. L. Aper ◽

M. D. Brown ◽

M. G. Conzemius

Keyword(s):

Hip Joint ◽

Hip Dysplasia ◽

Clinical Effect ◽

Pelvic Osteotomy ◽

Alternative Method ◽

Angular Measurements ◽

Si Joint ◽

In Vivo Effects ◽

Canine Hip Dysplasia

SummaryTreatment of canine hip dysplasia (CHD) via triple pelvic osteotomy (TPO) is widely accepted as the treatment that best preserves the existing hip joint. TPO, however, has several important disadvantages. In an effort to avoid some of the difficulties associated with TPO an alternative method of creating acetabular ventroversion (AW) was sought. The purpose of this study was to explore the effects of placement of a wedge in the sacroiliac (SI) joint on A W and to compare this to the effect of TPO on A W . On one hemipelvis a 30° pelvic osteotomy plate was used for TPO. The contralateral hemipelvis had a 28° SI wedge inserted into the SI joint. Pre- and postsurgical radiographs of each pelvis were taken and the angular measurements were recorded. On average, the 28° SI wedge resulted in 20.9° of A W, the 30° canine pelvic osteotomy plate resulted in 24.9° A W . Significant differences were not found (p >0.05) between the two techniques. Sacroiliac wedge rotation effectively creates A W and has several theoretical advantages when compared to TPO. The in vivo effects of sacroiliac wedge rotation should be studied in order to evaluate the clinical effect of the technique.Sacroiliac wedge rotation was tested as an alternative method to increase the angle of acetabular ventroversion. This technique effectively rotated the acetabulum and has several theoretical advantages when compared to triple pelvic osteotomy.

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