Molecular characterization of poliovirus isolates from children who contracted vaccine-associated paralytic poliomyelitis (VAPP) following administration of monovalent type 3 oral poliovirus vaccine in the 1960s in Hungary

2010 ◽  
Vol 58 (2) ◽  
pp. 211-217 ◽  
Author(s):  
Beatrix Kapusinszky ◽  
Zsuzsanna Molnár ◽  
Katalin N. Szomor ◽  
György Berencsi
Keyword(s):  
Molecular Characterization ◽  
Oral Poliovirus Vaccine ◽  
Paralytic Poliomyelitis ◽  
The 1960S ◽  
Type 3

Oral poliovirus vaccine in the United States: Molecular characterization of sabin type 3 after replication in the gut of vaccinees

1991 ◽  
Vol 35 (2) ◽  
pp. 101-109 ◽  
Author(s):  
Joanne M. Tatem ◽  
Carolyn Weeks-Levy ◽  
Steven J. Mento ◽  
Susan J. Dimichele ◽  
Alice Georgiu ◽  
...  
Keyword(s):  
United States ◽  
Molecular Characterization ◽  
The United States ◽  
Oral Poliovirus Vaccine ◽  
Type 3

scholarly journals Case of Poliomyelitis Caused by Significantly Diverged Derivative of the Poliovirus Type 3 Vaccine Sabin Strain Circulating in the Orphanage

Viruses ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 970
Author(s):  
Ekaterina A. Korotkova ◽  
Maria A. Prostova ◽  
Anatoly P. Gmyl ◽  
Liubov I. Kozlovskaya ◽  
Tatiana P. Eremeeva ◽  
...  
Keyword(s):  
Genome Sequencing ◽  
Mucosal Immunity ◽  
Neutralizing Antibodies ◽  
Oral Poliovirus Vaccine ◽  
Paralytic Poliomyelitis ◽  
Epidemiological Investigation ◽  
Poliovirus Type ◽  
Complete Rejection ◽  
Type 3

Significantly divergent polioviruses (VDPV) derived from the oral poliovirus vaccine (OPV) from Sabin strains, like wild polioviruses, are capable of prolonged transmission and neuropathology. This is mainly shown for VDPV type 2. Here we describe a molecular-epidemiological investigation of a case of VDPV type 3 circulation leading to paralytic poliomyelitis in a child in an orphanage, where OPV has not been used. Samples of feces and blood serum from the patient and 52 contacts from the same orphanage were collected twice and investigated. The complete genome sequencing was performed for five polioviruses isolated from the patient and three contact children. The level of divergence of the genomes of the isolates corresponded to approximately 9–10 months of evolution. The presence of 61 common substitutions in all isolates indicated a common intermediate progenitor. The possibility of VDPV3 transmission from the excretor to susceptible recipients (unvaccinated against polio or vaccinated with inactivated poliovirus vaccine, IPV) with subsequent circulation in a closed children’s group was demonstrated. The study of the blood sera of orphanage residents at least twice vaccinated with IPV revealed the absence of neutralizing antibodies against at least two poliovirus serotypes in almost 20% of children. Therefore, a complete rejection of OPV vaccination can lead to a critical decrease in collective immunity level. The development of new poliovirus vaccines that create mucosal immunity for the adequate replacement of OPV from Sabin strains is necessary.

Molecular Characterization of Transforming Growth Factor Type ?3

1990 ◽  
Vol 593 (1 Transforming) ◽  
pp. 26-42 ◽  
Author(s):  
PETER DIJKE ◽  
KENNETH K. IWATA ◽  
MIDORY THORIKAY ◽  
JANINE SCHWEDES ◽  
ALEXANDER STEWART ◽  
...  
Keyword(s):  
Growth Factor ◽  
Molecular Characterization ◽  
Transforming Growth Factor ◽  
Factor Type ◽  
Type 3

Molecular characterization of Iranian patients with type 3 von Willebrand disease

Haemophilia ◽  
2009 ◽  
Vol 15 (5) ◽  
pp. 1058-1064 ◽  
Author(s):  
S. SHAHBAZI ◽  
R. MAHDIAN ◽  
F. A. ALA ◽  
J.-M. LAVERGNE ◽  
C. V. DENIS ◽  
...  
Keyword(s):  
Molecular Characterization ◽  
Von Willebrand Disease ◽  
Type 3 ◽  
Von Willebrand ◽  
Iranian Patients

Molecular characterization of type 3 (neuronopathic) Gaucher disease in Thai patients

2007 ◽  
Vol 39 (3) ◽  
pp. 348-352 ◽  
Author(s):  
P. Suwannarat ◽  
S. Keeratichamroen ◽  
D. Wattanasirichaigoon ◽  
L. Ngiwsara ◽  
J.R.K. Cairns ◽  
...  
Keyword(s):  
Molecular Characterization ◽  
Gaucher Disease ◽  
Type 3

Comparative Molecular Characterization of Three Gallid alphaherpesvirus Type 3 Strains 301B/1, HPRS24, and SB-1

2020 ◽  
Vol 64 (2) ◽  
pp. 174
Author(s):  
Taejoong Kim ◽  
Jeremy D. Volkening ◽  
Stephen J. Spatz
Keyword(s):  
Molecular Characterization ◽  
Type 3

scholarly journals Fungal Metabolic Model for Tyrosinemia Type 3: Molecular Characterization of a Gene Encoding a 4-Hydroxy-Phenyl Pyruvate Dioxygenase from Aspergillus nidulans

2006 ◽  
Vol 5 (8) ◽  
pp. 1441-1445 ◽  
Author(s):  
Márcia Eliana da Silva Ferreira ◽  
Marcela Savoldi ◽  
Pierina Sueli Bonato ◽  
Maria Helena S. Goldman ◽  
Gustavo H. Goldman
Keyword(s):  
Aspergillus Nidulans ◽  
Molecular Characterization ◽  
Mutant Strain ◽  
Metabolic Model ◽  
Gene Encoding ◽  
Hereditary Tyrosinemia ◽  
Type 3

ABSTRACT Mutations in the human HPD gene (encoding 4-hydroxyphenylpyruvic acid dioxygenase) cause hereditary tyrosinemia type 3 (HT3). We deleted the Aspergillus nidulans homologue (hpdA). We showed that the mutant strain is not able to grow in the presence of phenylalanine and that it accumulates increased concentrations of tyrosine and 4-hydroxyphenylpyruvic acid, mimicking the human HT3 phenotype.

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