Visual acuity in a population with regular screening for type 2 diabetes mellitus and eye disease

Purpose:To determine the prevalence of advanced diabetic eye disease (ADED ) in patients with type 2 diabetes mellitus (DM) attending a tertiary eye care centre in eastern India and the risk factors associated with the disease. Methods: All patients of type 2 DM attending at the out-patient-department of a tertiary eye care centre, with any stage of diabetic retinopathy (DR) were recruited for this study. Examination was carried out with the help of slit-lamp biomicroscope with +90D lens, direct and indirect ophthalmoscopy, Snellen's chart, refraction trial lens and B-scan Ultrasonography. Medical records were reviewed and data were extracted. Results: Out of 200 patients with DR, 22 patients presented with advanced diabetic eye disease (ADED). Thus, the prevalence of ADED in this study was 11%. Those with increased age of presentation, long duration of DM, deranged HbA1c and lipid prole are at signicantly higher risk of presenting with ADED. Conclusion: Prevalence of 11 % of ADED in patients with DM attending a tertiary eye care centre shows that this condition continues to be a major social problem despite current knowledge about advanced DR.

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PPARG Polymorphisms Are Associated with Unexplained Mild Vision Loss in Patients with Type 2 Diabetes Mellitus

Journal of Ophthalmology ◽

10.1155/2019/5284867 ◽

2019 ◽

Vol 2019 ◽

pp. 1-7 ◽

Cited By ~ 1

Author(s):

Tao Li ◽

Xian Xu ◽

Yi Xu ◽

Peiyao Jin ◽

Jianhua Chen ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Visual Acuity ◽

Type 2 Diabetes Mellitus ◽

Visual Impairment ◽

Vision Loss ◽

Corrected Visual Acuity ◽

Pparg Gene ◽

Best Corrected Visual Acuity

Objectives. To investigate whether the presence of peroxisome proliferator-activated receptor gamma (PPARG) gene polymorphisms is associated with unexplained mild visual impairment (UMVI) in patients with type 2 diabetes mellitus (T2DM). Methods. A total of 135 T2DM residents with UMVI and 133 with normal vision (NV; best-corrected visual acuity ≥ 20/25 in both eyes) were enrolled. UMVI was defined as best-corrected visual acuity (BCVA) < 20/25 and ≥ 20/63 in both eyes, with no visual impairment-causing diseases found. Four PPARG gene single-nucleotide polymorphisms (SNPs) (rs3856806, rs1801282, rs709158, and rs10865710) were assessed with the HAPLOVIEW 4.0 software to examine the statistical association of PPARG polymorphisms and UMVI in patients with T2DM. Results. Four SNPs qualified the Hardy–Weinberg equilibrium (p>0.05). The frequency of genotype GC at SNP rs10865710 was significantly higher in the UMVI group than in the NV group (p<0.001; GG + GC versus CC) (OR = 8.94, 95% CI: 4.90–16.31), whereas genotype CC decreased the risk (OR = 0.07, 95% CI: 0.03–0.14). Genotype TT at SNP rs3856806 was strongly associated with UMVI (p<0.0001, TT + TC versus CC) (OR = 4.74, 95% CI: 2.68–8.54), whereas genotype CC appeared to be protective for UMVI (OR = 0.55, 95% CI: 0.37–0.82). Conclusions. Susceptibilities of PPARG variants may lead to differences in PPARG transcription, result in early function loss of retinal photoreceptor cells, and eventually cause UMVI.

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Correlation between optical coherence tomography-derived macular measurements and glycosylated haemoglobin, age, visual acuity and diabetes duration in patients with type 2 diabetes mellitus

International Journal of Diabetes in Developing Countries ◽

10.1007/s13410-015-0362-8 ◽

2015 ◽

Vol 35 (S3) ◽

pp. 385-388

Author(s):

Visvaraja Subrayan ◽

Sudha Menon ◽

Mohammadreza Peyman ◽

Angela loo voon pei

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Optical Coherence Tomography ◽

Visual Acuity ◽

Type 2 Diabetes Mellitus ◽

Glycosylated Haemoglobin ◽

Diabetes Duration ◽

Optical Coherence

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Meta-herpetic ulcer following intravitreal bevacizumab

European Journal of Ophthalmology ◽

10.1177/1120672120952035 ◽

2020 ◽

pp. 112067212095203

Author(s):

Geeta Behera ◽

Tanmay Gokhale ◽

Amit Kumar Deb ◽

Krishna Ramesh Babu

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Visual Acuity ◽

Type 2 Diabetes Mellitus ◽

Severe Pain ◽

Intravitreal Bevacizumab ◽

Intravitreal Bevacizumab Injection ◽

The Right ◽

Bevacizumab Injection

Purpose: To report a case of meta-herpetic ulcer that developed after intravitreal bevacizumab injection. Methods: A 55-year-old man with type 2 diabetes mellitus and nephropathy received intravitreal injection of bevacizumab in his right eye for proliferative diabetic retinopathy with macular edema. Results: Two days after the injection, the patient presented with severe pain, redness, and photophobia, and decreased visual acuity in the right eye. The cornea showed a paracentral epithelial erosion with heaped margins with subepithelial haze and punctate keratopathy, and high intraocular pressure. He initially responded to topical antiviral and antiglaucoma medications. However, it rapidly progressed to a geographic ulcer on initiation of mild steroid and became resistant to conventional medical management. His nephropathy precluded treatment with full dose of systemic antivirals and antiglaucoma drugs. Subsequently, it healed after a paramedian tarsorrhaphy was performed. Conclusion: Herpetic epithelial keratitis following intravitreal bevacizumab is a rare occurence. However, this case is the first report of progression to a meta-herpetic ulcer.

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Research progress of lncRNAs in diabetic retinopathy

European Journal of Ophthalmology ◽

10.1177/1120672120970401 ◽

2020 ◽

pp. 112067212097040

Author(s):

Qinying Huang ◽

Jinying Li

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Visual Acuity ◽

Type 2 Diabetes Mellitus ◽

Diabetic Retinopathy ◽

Mechanisms Of Action ◽

Research Progress ◽

Future Research ◽

Non Coding Rnas

Diabetic retinopathy (DR), which is known as a severe complication of type 2 diabetes mellitus, can cause varying degrees of damage to visual acuity. The pathogenesis of DR is multifactorial and not fully understood. Many previous research studies have revealed that an aberrant level of some long non-coding RNAs (lncRNAs) may accelerate the development of DR. These lncRNAs are regulatory factors and research related to them is always underway. In this review, we will update several types of lncRNAs based on the previous studies which are related to the development of DR and discuss its potential mechanisms of action and connections. Generally, the review will help us know more about lncRNAs and provide directions for future research related to DR.

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