scholarly journals PPARG Polymorphisms Are Associated with Unexplained Mild Vision Loss in Patients with Type 2 Diabetes Mellitus

2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Tao Li ◽  
Xian Xu ◽  
Yi Xu ◽  
Peiyao Jin ◽  
Jianhua Chen ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Visual Acuity ◽  
Type 2 Diabetes Mellitus ◽  
Visual Impairment ◽  
Vision Loss ◽  
Corrected Visual Acuity ◽  
Pparg Gene ◽  
Best Corrected Visual Acuity

Objectives. To investigate whether the presence of peroxisome proliferator-activated receptor gamma (PPARG) gene polymorphisms is associated with unexplained mild visual impairment (UMVI) in patients with type 2 diabetes mellitus (T2DM). Methods. A total of 135 T2DM residents with UMVI and 133 with normal vision (NV; best-corrected visual acuity ≥ 20/25 in both eyes) were enrolled. UMVI was defined as best-corrected visual acuity (BCVA) < 20/25 and ≥ 20/63 in both eyes, with no visual impairment-causing diseases found. Four PPARG gene single-nucleotide polymorphisms (SNPs) (rs3856806, rs1801282, rs709158, and rs10865710) were assessed with the HAPLOVIEW 4.0 software to examine the statistical association of PPARG polymorphisms and UMVI in patients with T2DM. Results. Four SNPs qualified the Hardy–Weinberg equilibrium (p>0.05). The frequency of genotype GC at SNP rs10865710 was significantly higher in the UMVI group than in the NV group (p<0.001; GG + GC versus CC) (OR = 8.94, 95% CI: 4.90–16.31), whereas genotype CC decreased the risk (OR = 0.07, 95% CI: 0.03–0.14). Genotype TT at SNP rs3856806 was strongly associated with UMVI (p<0.0001, TT + TC versus CC) (OR = 4.74, 95% CI: 2.68–8.54), whereas genotype CC appeared to be protective for UMVI (OR = 0.55, 95% CI: 0.37–0.82). Conclusions. Susceptibilities of PPARG variants may lead to differences in PPARG transcription, result in early function loss of retinal photoreceptor cells, and eventually cause UMVI.

scholarly journals Associations of molecular genetic predictors of type 2 diabetes mellitus with hyperglycemia in extremely low birth weight infants

2021 ◽  
Vol 18 (5) ◽  
pp. 62-68
Author(s):  
P. I. Mironov ◽  
N. N. Mingazov ◽  
R. R. Valiev ◽  
А. U. Lekmanov
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Body Weight ◽  
Neonatal Intensive Care ◽  
Polymorphic Locus ◽  
Population Sample ◽  
Neonatal Intensive Care Units ◽  
Pparg Gene

Hyperglycemia in premature newborns is an independent risk factor for death, so blood glucose testing is widely used in the practice of neonatal intensive care units.Objective: to evaluate the associations of the frequency of carriage of allelic variants of polymorphic loci of genes predisposing to type 2 diabetes mellitus in newborns with extremely low body weight and hyperglycemia.Methods. The study design is prospective, controlled, single – center, non-randomized. Genomic DNA samples were studied in newborn infants with extremely low body weight (ELBW) (n = 105). Previously, we compared the distribution of allele frequencies of the studied genes between a group of newborns with ELBW and a population sample of adults (control). Then, the distribution of allele frequencies of the genes was compared depending on the presence of hyperglycemia in newborns with ELBW. For the analysis, loci with already known association with the development of type 2 diabetes mellitus were selected ‒ ADRB2 (rs1042713) and (rs1042714), ADRB3 (rs4994), GNB3 (rs5443), PPARA (rs4253778), PPARD (rs2016520), TCF7L2_IVS3 (rs7903146) and TCF7L2_IVS4 (rs12255372), PPARGC1A (rs8192678), MTHFR (rs1801131), PPARG (rs1801282), MTNR1B (rs10830963), SIRT1 (rs7069102).Results. In newborns with ELBW, we found a more frequent occurrence of the mutant allele A of the polymorphic locus rs8192678 in the PPARGC1A gene and the allele C of the polymorphic locus rs4253778 in the PPARA gene, in contrast to the adult population sample. But in newborns with ELBW, hyperglycemia is most likely associated with the carrier of the allele C rs1801282 of the PPARG gene (χ2 = 18.972, p < 0.001) and the allele T rs7903146 in the TCF7L2 gene (χ2 = 11.496, p < 0.001).Conclusions. The carriage of the allele С rs1801282 of the PPARG gene is characterized by the presence of a strong conjugation with hyperglycemia in newborns with extremely low body weight. It is desirable to monitor the level of glycemia in the conditions of neonatal intensive care units, taking into account the carriage of genes predisposing to hyperglycemia.

scholarly journals Cribado de la retinopatía diabética en el primer nivel de atención usando retinografía en la Ciudad de México

2018 ◽  
Vol 16 (2) ◽  
pp. 11-19
Author(s):  
Daniel Paniagua Herrera ◽  
Consuelo González Salinas
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Primary Care ◽  
Type 2 Diabetes Mellitus ◽  
Macular Edema ◽  
Diabetic Macular Edema ◽  
Vision Loss ◽  
Tertiary Care ◽  
Number Of Patients

Objective:To determine the prevalence of diabetic retinopathy and diabetic macular edema by means of retinography in patients diagnosed with Type 2 diabetes mellitus according to time of evolution and degree of vision loss with and without refractive correction.Method: A descriptive cross-sectional study of 150 patients with Type 2 diabetes mellitus assessed in optometry in various health centers from the Sanitary Jurisdiction of Tlalpan, Health Services of Mexico City.Results: 150 patients (70% women, 30% men) aged 60 (+/– 7.77) were diagnosed with Type 2 diabetes mellitus, 52% of them with an evolution of 12.09 years (+/– 3.48). Of the total number of patients, 72.33% had retinopathy and/or diabetic macular edema lesions. The average visual acuity improved from 0.62 (+/– 0.48) to 0.37 (+/– 0.38) with refractive correction, absolute disability decreased by –18.76% and null or slight disability increased by 31.31%. Of the total population, 75.5% remained under monitoring in primary care, and 24.5% were referred to tertiary care in ophthalmology.Conclusion: The strategic opportunity to combat vision loss due to retinopathy and diabetic macular edema is found in its timely detection by health personnel trained in scrutiny and control at the primary care level, which would represent a decreased hospital load in tertiary care, thereby reducing costs for the health systems, as well as cost-efficiency for the years of sight gained and optimization of the patient’s global vision.

scholarly journals The Prevalence and Causes of Visual Impairment in Type 2 Diabetes Mellitus in Northeast China

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Liang Wen ◽  
Yu Wang ◽  
Zhong Lin ◽  
Feng Hua Wang ◽  
Xiao Xia Ding ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Visual Acuity ◽  
Visual Impairment ◽  
Refractive Error ◽  
Northeast China ◽  
Low Vision ◽  
Uncorrected Refractive Error ◽  
Myopic Maculopathy

Purpose. To evaluate the prevalence and causes of visual impairment in a group of community people with type 2 diabetes mellitus (T2DM) in Northeast China. Methods. Population-based cross-sectional survey. Patients diagnosed with T2DM residing in 15 communities in Fushun, Northeast China, were enrolled between July 2012 and May 2013. All participants underwent an extensive and standardized eye examination (visual acuity testing, slit-lamp, and fundus examination). Low vision was defined as presenting VA of better-seeing eye <20/60 and ≥20/400, and blindness was defined as VA <20/400, according to the World Health Organization (WHO) definitions. The primary causes of blindness and low vision were assessed by senior ophthalmologists. Results. Visual acuity measurements were available for 1998 (89.8%) of 2224 subjects in the study. The prevalence of bilateral blindness and low vision defined was 0.90% and 10.81%. Uncorrected refractive error was the first leading cause of low vision (75.0%) and blindness (38.9%). After correcting the refractive error, the first leading cause of low vision was cataract (44.4%), followed by diabetic retinopathy (29.6%) and myopic maculopathy (18.5%), while the first leading cause of blindness was proliferative DR (45.4%), followed by cataract (36.4%) and myopic maculopathy (18.2%). Conclusions. This study suggested a high prevalence of low vision and blindness in this study cohort. Uncorrected refractive error and cataract remain the leading cause of visual impairment, but the major challenge is the early diagnosis and intervention of diabetic retinopathy to reduce diabetes-related blindness.

Meta-herpetic ulcer following intravitreal bevacizumab

2020 ◽  
pp. 112067212095203
Author(s):  
Geeta Behera ◽  
Tanmay Gokhale ◽  
Amit Kumar Deb ◽  
Krishna Ramesh Babu
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Visual Acuity ◽  
Type 2 Diabetes Mellitus ◽  
Severe Pain ◽  
Intravitreal Bevacizumab ◽  
Intravitreal Bevacizumab Injection ◽  
The Right ◽  
Bevacizumab Injection

Purpose: To report a case of meta-herpetic ulcer that developed after intravitreal bevacizumab injection. Methods: A 55-year-old man with type 2 diabetes mellitus and nephropathy received intravitreal injection of bevacizumab in his right eye for proliferative diabetic retinopathy with macular edema. Results: Two days after the injection, the patient presented with severe pain, redness, and photophobia, and decreased visual acuity in the right eye. The cornea showed a paracentral epithelial erosion with heaped margins with subepithelial haze and punctate keratopathy, and high intraocular pressure. He initially responded to topical antiviral and antiglaucoma medications. However, it rapidly progressed to a geographic ulcer on initiation of mild steroid and became resistant to conventional medical management. His nephropathy precluded treatment with full dose of systemic antivirals and antiglaucoma drugs. Subsequently, it healed after a paramedian tarsorrhaphy was performed. Conclusion: Herpetic epithelial keratitis following intravitreal bevacizumab is a rare occurence. However, this case is the first report of progression to a meta-herpetic ulcer.

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