Bacterial vaginosis - a disturbed bacterial flora and treatment enigma. Review article IV

Apmis ◽  
2005 ◽  
Vol 113 (5) ◽  
pp. 305-316 ◽  
Author(s):  
P. G. LARSSON ◽  
U. FORSUM
2019 ◽  
Vol 7 (12) ◽  
pp. 118-121
Author(s):  
Sunanda a ◽  
◽  
Bansal Puja ◽  
Bhargava Deepak ◽  
◽  
...  

2002 ◽  
Vol 13 (7) ◽  
pp. 449-452 ◽  
Author(s):  
D Taylor-Robinson ◽  
M McCaffrey ◽  
J Pitkin ◽  
R F Lamont

The objective was to determine how frequently an abnormal vaginal flora occurred in women attending a menopause clinic and whether any abnormality might be related to a particular risk factor. Women completed a questionnaire on their gynaecological, sexual and medical history. Whether they were perimenopausal or postmenopausal was determined on the basis of symptomatology, duration of amenorrhoea and on a follicle-stimulating hormone (FSH) assay when clinically indicated. A speculum examination of the vagina was undertaken, at which time a smear of vaginal secretion was Gram stained and the bacterial flora graded as follows: grade 1, normal; grade 2, intermediate, and grade 3, bacterial vaginosis (BV). Of 100 women examined, 44 had grade 1 flora, 17 had grade 2 flora and 18 had BV. An apparent absence of, or very scanty, vaginal bacteria in which grading was not possible was found in 21 women. Women with BV had had more sexual partners than the others, but otherwise there were no discernible factors associated with the occurrence of BV. Women with vaginal atrophy were more likely to have an apparent absence of vaginal bacteria, but a few had BV.


2021 ◽  
Vol 9 (B) ◽  
pp. 1681-1685
Author(s):  
Irena Andonova ◽  
Vasil Iliev

Bacterial vaginosis and periodontal diseases share very similar pathogenesis. Each of these diseases occurs when healthy microbiome changes to predominately anaerobic bacterial flora. Bacterial vaginosis is proven factor for adverse pregnancy outcomes. In recent years it has been hypothesized that infection from distant sites of the fetoplacental unit may also elicit an inflammatory response in utero. Aim: The study is designed to determine whether the presence of specific oral anaerobic bacteria in subgingival sulcus of mother increase the risk of adverse obstetric outcomes. Material and Methods: Case-control study.  Control group: 50 patients who gave birth to neonate whit normal birth weight at term. Group cases: I group - 40 pregnant women who were hospitalized with signs of preterm labor. II - 20 pregnant women, who have an ultrasound diagnosis of fetal growth retardation. Sub-gingival microbiological paper-point swab was taken in all patients. Results: The total number of isolated oral anaerobic bacteria was statistically significantly higher in the cases group compared to control group p <0.01. In our study, pregnant women who tested positive for Porphyrmonas gingivalis for 6.65 times were more likely to have preterm labor compare with pregnant women with negative oral swabs (95.0% CI: 1.38-32.11 / p <0.05), and for 2,79 times more likely to have fetus with intrauterine growth restriction (95.0% CI: 1.10-7.91 / p <0.05 Conclusions: The study confirmed the hypothesis of a statistically significant association between oral anaerobic infection and adverse pregnancy outcomes. In the future, more studies are needed to investigate the role of the microbial load, maternal immune response, pathophysiological pathway that leads to negative pregnancy outcome.  


2002 ◽  
Vol 10 (3) ◽  
pp. 133-140 ◽  
Author(s):  
Per-Göran Larsson ◽  
Bodil Carlsson

Objective:Bacterial vaginosis (BV) is a known risk factor for postoperative infection following abdominal hysterectomy. Vaginal bacterial flora scored as intermediate has been shown to have the same risk of postoperative infection as BV.Methods:Women undergoing total abdominal hysterectomy for benign diseases were open-randomized according to Zelen to either treatmentwith metronidazole rectally for at least 4 days or no treatment. At the preoperative gynecological examination a vaginal smear was collected and Gram stained. Women with BV or intermediate flora were merged to one group called abnormal vaginal flora.Results:In total 213 women were randomized to treatment or no treatment. After exclusion of 71 women, 142 women were eligible for analysis. Among the 59 women diagnosed with abnormal vaginal flora there were no vaginal cuff infections in the treated arm, comparedwith 27% in the ‘no treatment’ arm (p<0.01). Treatment also reduced the vaginal cuff infection rate from 9.5 to 2% among the 83 women with lactobacilli flora. However, this difference was not statistically significant. Treatment had no effect on the rate of wound infections. Intention-to-treat analysis showed a significant reduction in vaginal cuff infections among women randomized to treatment.Conclusion:Pre- and postoperative treatment for at least 4 days with metronidazole rectally reduces significantly vaginal cuff infection among women with abnormal vaginal flora.


Apmis ◽  
2005 ◽  
Vol 113 (4) ◽  
pp. 233-245 ◽  
Author(s):  
P. G. LARSSON ◽  
M. BERGSTROM ◽  
U. FORSUM ◽  
B. JACOBSSON ◽  
A. STRAND ◽  
...  

2017 ◽  
Vol 95 (1) ◽  
pp. 31-33 ◽  
Author(s):  
Katsufumi Otsuki ◽  
Noriaki Imai

We previously reported that lactoferrin (LF) could be effective for preventing preterm delivery and intrauterine infections, based on data derived from mice and rabbits. Here we describe 6 women with a history of multiple pregnancy losses or preterm delivery and refractory bacterial vaginosis, who received prebiotic LF therapy and delivered an infant normally. Five of the women were pregnant and one was not at the time of this study. The Ethics Committee at Showa University Hospital and Showa University Koto Toyosu Hospital approved the therapeutic protocol. Vaginal suppositories and oral prebiotic LF were administered to patients who were refractory to conventional treatment for vaginosis and had a history of late miscarriages and very early preterm delivery due to refractory vaginitis and chorioamnionitis. LF significantly improved the vaginal bacterial flora. Lactobacillus, which was detectable in the vaginas of all patients after one month of LF therapy, gradually became dominant. The findings from these 6 patients suggest that administering LF to humans could help prevent refractory vaginitis, cervical inflammation, and preterm delivery.


Apmis ◽  
2005 ◽  
Vol 113 (3) ◽  
pp. 153-161 ◽  
Author(s):  
URBAN FORSUM ◽  
ANDERS HALLEN ◽  
P. G. LARSSON

10.3823/848 ◽  
2020 ◽  
Vol 10 (3) ◽  
Author(s):  
Eman F Badran ◽  
Asem A Shehabi ◽  
Malak A Khanfar

Kingella kingae is a Gram-negative coccobacilli and it is a member of the HACEK (Haemophilus species, Aggregatibacte actinomycetemcomitans, Cardiobacterium hominis, Eikenella corrodens, and  K. kingae). HACEK organisms are typically oropharyngeal commensals and have long been recognized as a cause of infective endocarditis in children and adults. K. kingae in difficult to be recovered from cultured pharyngeal samples due to its slow growth and the high presence of resident bacterial flora, however, the organism can be better detected using PCR tests. Based on our search in PubMed and other sources, we couldn't discover any study about K. kingae originated from any Arab country. Therefore, we wrote this review to draw the attention of our physicians and clinical microbiologists on the importance of this neglected group of organisms in clinical medicine.   However, this review article aims to cover the most important diseases of K. kingae in the pediatric population.


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