Osteogenesis distraction and platelet-rich plasma: combined use in restoration of severe atrophic mandible. Long-term results

2008 ◽  
Vol 19 (11) ◽  
pp. 1202-1210 ◽  
Author(s):  
M. Robiony ◽  
E. Zorzan ◽  
F. Polini ◽  
S. Sembronio ◽  
C. Toro ◽  
...  
Keyword(s):  
Platelet Rich Plasma ◽  
Long Term Results ◽  
Combined Use

Long-term Results of Mucosal Advancement Flap Combined With Platelet-rich Plasma for High Cryptoglandular Perianal Fistulas

2014 ◽  
Vol 57 (2) ◽  
pp. 223-227 ◽  
Author(s):  
Kevin W. Göttgens ◽  
Wouter Vening ◽  
Stefan J. van der Hagen ◽  
Wim G. van Gemert ◽  
Reinier R. Smeets ◽  
...  
Keyword(s):  
Platelet Rich Plasma ◽  
Advancement Flap ◽  
Long Term Results ◽  
Perianal Fistulas

De-Epithelialized Heterotopic Tracheal Allografts without Immunosuppressants in Dogs: Long-Term Results for Cartilage Viability and Structural Integrity

2020 ◽  
pp. 000348942095735
Author(s):  
Pengcheng Cui ◽  
Pengfei Liu ◽  
Shuqin Li ◽  
Ruina Ma
Keyword(s):  
Organ Preservation ◽  
Structural Integrity ◽  
Sodium Dodecyl ◽  
Long Term Results ◽  
Preservation Solution ◽  
Chondrocyte Viability ◽  
Organ Preservation Solution ◽  
Combined Use ◽  
Immunological Rejection

Objectives: Reconstruction of long segmental tracheal defects is difficult because no ideal tracheal substitutes are currently available. Tracheal allotransplantation maintains cartilage and epithelium viability but requires immunosuppression because of epithelial immunogenicity. We aimed to obtain an epithelium-decellularized allograft that maintains cartilage viability and to evaluate long-term outcomes of such allografts implanted on dog backs without immunosuppressants. Methods: Twenty-five tracheas harvested from mongrel dogs were used to explore the period of epithelium decellularization by combined use of 1% sodium dodecyl sulfate and an organ preservation solution and to assess the chondrocyte viability and immunogenicity of the tracheas after decellularization. Sixteen epithelium-decellularized tracheal allografts and 10 fresh tracheal segments (6 cm long) were implanted in 26 beagles for durations of 10 days and 1, 3, 6, and 12 months. Macroscopic and microscopic examinations were used to evaluate the morphology, viability, and immune rejection of the allografts. Safranin-O staining was used to detect glycosaminoglycans. Results: The epithelium disappeared after 24 hours of decellularization. At 72 hours, almost no nuclei remained in the mucosa, while the mean survival rate of chondrocytes was 88.1%. Histological analysis demonstrated that the allograft retained intact tracheal rings and viable cartilage after heterotopic implantation for 1 year, with no immunological rejection. There were no significant differences in the glycosaminoglycan contents among the implanted epithelium-decellularized allografts. Conclusions: Epithelium-decellularized tracheal allografts with chondrocyte viability can be achieved by combined use of a detergent and organ preservation solution, which showed satisfactory cartilage viability and structural integrity after long-term heterotopic transplantation. Further studies on orthotopic transplantation are needed to assess the feasibility of allografts in reconstructing long segmental tracheal defects.

scholarly journals Minimalistic reconstruction of exposed skull in a complex craniovertebral polytrauma

2021 ◽  
Vol 12 ◽  
pp. 248
Author(s):  
Srinjoy Saha
Keyword(s):  
Local Anesthesia ◽  
Soft Tissues ◽  
Platelet Rich Plasma ◽  
Skin Grafting ◽  
Long Term Results ◽  
Soft Tissue Thickness ◽  
Split Skin Grafting ◽  
Split Skin ◽  
Skull Bones

Background: In stable craniovertebral injuries complicated by polytrauma, rigorous spinal immobilization is essential for neuroprotection. Scalp and forehead reconstruction in these circumstances are safest when performed under local anesthesia, maintaining cervical immobilization. Case Description: A sizeable 10 × 6.5 cm forehead defect was reconstructed utilizing regenerative principles under local anesthesia and sedation in a 54-year-old woman. After adequate debridement of gangrenous soft tissues, exposed outer skull bones were trephined, forehead defect covered with a synthetic biomaterial, and the patient was discharged thereafter. Granulating neodermis regenerated within the biomaterial over the next 6 weeks. Weekly platelet-rich plasma injections along the wound margins facilitated wound regeneration. Dimensions reduced by two-thirds to 6.5 × 3.5 cm with wound regeneration and contraction, while granulating neodermis covered the remaining skull-bones. Split skin-grafting over the neodermis ensured satisfying long-term results, with similar color, texture, soft-tissue thickness, and sensation. Multiple occipitocervical, spinal, scapular, and rib fractures healed well with strict immobilization. Conclusion: Good long-term results were achieved with significantly reduced dangers, complications, hospitalization, and costs than traditional reconstructive flap surgeries. Minimalistic reconstruction utilizing tissue engineering and regenerative medicine principles appears beneficial for patients with grave spinal injuries.

scholarly journals Long-Term Influence of Platelet-Rich Plasma (PRP) on Dental Implants after Maxillary Augmentation: Retrospective Clinical and Radiological Outcomes of a Randomized Controlled Clinical Trial

2020 ◽  
Vol 9 (2) ◽  
pp. 355 ◽  
Author(s):  
Sameh Attia ◽  
Clara Narberhaus ◽  
Heidrun Schaaf ◽  
Philipp Streckbein ◽  
Jörn Pons-Kühnemann ◽  
...  
Keyword(s):  
Dental Implants ◽  
Platelet Rich Plasma ◽  
Controlled Trial ◽  
Long Term Results ◽  
Control Group ◽  
Iliac Crest Bone Graft ◽  
Controlled Clinical Trial ◽  
Positive Effects ◽  
Randomized Controlled

The long-term clinical and radiological outcomes of dental implants inserted in augmented bone treated with platelet-rich plasma (PRP) has not been well addressed in the literature yet. This study is based on a collection of patients from a randomized controlled trial (RCT) that did not report any short-term positive effects of PRP on bone healing after sinus lift surgery using autologous iliac crest bone graft. This study aimed to evaluate the long-term impact of PRP regarding clinical and radiological outcomes on the inserted implants in the previous RCT. For this evaluation, we considered the following variables: plaque index, probing depth, bleeding index, mobility grade, Periotest® values, and radiological bone loss. Out of 53 patients (n = 306 implants) included in the previous study we were able to reinvestigate 37 patients (n = 210 implants) in two centers (31 in Giessen, Germany and 6 in Erlangen, Germany). Clinical and radiographic parameters suggested overall healthy conditions of the peri-implant tissue. The PRP-group and the control group did not differ significantly in the majority of the parameters. The overall evaluation showed that result data of the PRP-group was inferior to the control group in 64 percent of the evaluated parameters. The present study cannot provide evidence of a positive effect of PRP on the long-term implant clinical and radiological outcomes. In fact, a tendency towards inferior long-term results in the PRP-group was detected without reaching a significant threshold. Further controlled trials need to be conducted to investigate this correlation.

STIMULYaTsIYa TERAPEVTIChESKOGO DEYSTVIYa KhONDROPROTEKTOROV PRI LEChENII DEFORMIRUYuShchEGO ARTROZA KOLENNOGO SUSTAVA

2003 ◽  
Vol 10 (1) ◽  
pp. 60-62
Author(s):  
G M Dubrovin
Keyword(s):  
Clinical Outcomes ◽  
Long Term Results ◽  
Control Group ◽  
Therapeutic Action ◽  
Combined Use ◽  
Knee Arthrosis ◽  
Stimulation Of

Method for stimulation of therapeutic action of chondroprotectors using polarization light and vibrotherapeutics was suggested for the treatment of deforming arthrosis. The main drug was alphlutop - chondroprotector out of glucosaminoglycanes group. Ninety patients with deforming knee arthrosis of I-III degree in sub- and decompensated forms were treated. Control group (without stimulation) consisted of 20 patients. In 70 patients different variants of stimulation were used. Long term results were evaluated in terms up to 2-3 years. It was detected that combined use of polarization light, chondroprotectors, vibrotherapeutics allowed to achieve higher clinical outcomes and prolonged remission.

scholarly journals Complex Treatment of Patients With Chronic Generalized Periodontitis of a Medium Degree of Severity Using the Methods of Osteogygivoplasty With Biocomposite Materials and Guided Tissue Regeneration

2021 ◽  
Vol 7 (4) ◽  
pp. 154-163
Author(s):  
A. Imanalieva ◽  
P. Abaskanova ◽  
O. Tursunaliev ◽  
B. Bakiev ◽  
K. Kuttubaeva
Keyword(s):  
Tissue Regeneration ◽  
Platelet Rich Plasma ◽  
Interdisciplinary Approach ◽  
Guided Tissue Regeneration ◽  
Collagen Membrane ◽  
Complex Treatment ◽  
Surgical Interventions ◽  
X Ray ◽  
Combined Use

Improvement of methods of complex treatment of periodontium diseases continues to be an urgent problem of dentistry and requires an interdisciplinary approach. The severity of the course of periodontitis and the severity of destructive phenomena dictates the need to use osteoplastic agents to restore damaged periodontium tissues. It has been proven that the efficiency of membrane technology is significantly increased when membranes and substitute materials are used together. The positive effect of the combined use of Platelet Rich Plasma (PRP — autogenous growth factors), osteoplastic materials, and the method of Guided Tissue Regeneration (GTR) has been confirmed. To increase the efficiency of reconstructive treatment of patients with generalized periodontitis through the combined use of alloplasty, Platelet Rich Plasma, and the method of Guided Tissue Regeneration. Method of testing: clinical, X-ray. For the period 2018–2019, 34 patients with chronic generalized periodontal atrophy of moderate severity were under observation. All patients underwent professional oral hygiene, laser therapy, and antibacterial therapy with rovamycin. 6 patients in complex therapy underwent surgical interventions: osteogingivoplasty with biocomposite materials using GTR auto-allogenic membranes. Bone defects were filled with biocomposite material: hydroxylappatite granules (Polistom, RF) in combination with PRP, on top of an alto plasma membrane isolated from PRP and collagen membrane (Polistom, RF). The immediate and long-term periods of treatment were quite favorable. Control X-ray examination after 12 months showed restoration of a bone defect with an organotypic structure.

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