Histiocytic, necrotizing lymphadenitis as rare cause of cervical lymphadenopathy and fever of unknown origin - a case of biopsy proven recurrence over 19 years

2009 ◽  
Vol 63 (4) ◽  
pp. 282-283 ◽  
Author(s):  
Markus Kosch ◽  
Martin Hausberg ◽  
Michael Barenbrock ◽  
Karl Heinz Rahn ◽  
Klaus Kisters
Keyword(s):  
Fever Of Unknown Origin ◽  
Cervical Lymphadenopathy ◽  
Unknown Origin ◽  
Histiocytic Necrotizing Lymphadenitis ◽  
Necrotizing Lymphadenitis

scholarly journals Is recurrent Kikuchi-Fujimoto disease a precursor to systemic lupus erythematosus?

2019 ◽  
Vol 57 (1) ◽  
pp. 72-77
Author(s):  
Taro Horino ◽  
Osamu Ichii ◽  
Yoshio Terada
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Cervical Lymphadenopathy ◽  
Clinical Entity ◽  
Histiocytic Necrotizing Lymphadenitis ◽  
Systemic Lupus ◽  
Necrotizing Lymphadenitis

Abstract Kikuchi-Fujimoto disease (KFD), also known as histiocytic necrotizing lymphadenitis, is a rare, benign, self-limiting disease characterized by cervical lymphadenopathy and fever. Since KFD was first reported in 1972, the validity of this clinical entity has been controversial and its aetiology remains unknown. Herein, we report a case of a patient with KFD, which was believed to be associated with systemic lupus erythematosus.

scholarly journals Kikuchi necrotizing lymphadenopathy: a tip of the iceberg disease?

2021 ◽  
Vol 8 (9) ◽  
pp. 1602
Author(s):  
Sushil Singla ◽  
Mohitesh Kumar ◽  
Vinod Kumar Jat ◽  
Deepika Parwan
Keyword(s):  
Lymph Node ◽  
Laboratory Test ◽  
Young Patient ◽  
Healthy Individual ◽  
Cervical Lymphadenopathy ◽  
Lymph Node Biopsy ◽  
Histiocytic Necrotizing Lymphadenitis ◽  
Benign Condition ◽  
Node Biopsy ◽  
Necrotizing Lymphadenitis

Kikuchi-Fujimoto disease (KFD) is a rare benign condition also called histiocytic necrotizing lymphadenitis, which typically presented as fever with cervical lymphadenopathy in previously healthy individual. We presented a case of 11 year old boy with fever and cervical lymphadenopathy since 2 months. Lymph node biopsy was performed which suggested of KFD and was treated symptomatically. KFD incidence is rare but clinicians should be alert if young patient comes with fever and cervical lymphadenopathy to lower the chance of unwanted laboratory test and harmful treatment. 

scholarly journals Kikuchi-Fujimoto Disease: A Report of 3 Cases

2007 ◽  
Vol 86 (7) ◽  
pp. 412-413 ◽  
Author(s):  
Eimear Phelan ◽  
Emer Lang ◽  
Peter Gormley ◽  
John Lang
Keyword(s):  
Weight Loss ◽  
Cervical Lymphadenopathy ◽  
Lymph Node Biopsy ◽  
Accurate Diagnosis ◽  
Histiocytic Necrotizing Lymphadenitis ◽  
Kikuchi’S Disease ◽  
Node Biopsy ◽  
Night Sweats ◽  
Necrotizing Lymphadenitis ◽  
Kikuchi's Disease

Cervical lymphadenopathy has many underlying etiologies. One of its rare causes is Kikuchi-Fujimoto disease (Kikuchi's disease, histiocytic necrotizing lymphadenitis). We discovered such a cause in a 37-year-old woman who had presented with malaise, night sweats, and weight loss in addition to cervical lymphadenopathy. We based our diagnosis on excisional lymph node biopsy. We also review 2 other cases of Kikuchi's disease that were diagnosed by others at our institution. Clinically and histologically, Kikuchi's disease is very similar to lymphoma, and distinguishing the two is difficult. However, despite the fact that Kikuchi's disease is benign, an accurate diagnosis is important because misdiagnosis might lead to unnecessary surgery and/or chemotherapy.

scholarly journals Case Report: Kikuchi-Fujimoto Disease: A case of supraclavicular lymphadenopathy

F1000Research ◽  
2019 ◽  
Vol 8 ◽  
pp. 1652
Author(s):  
Shiza Sarfraz ◽  
Hamza Rafique ◽  
Hassam Ali ◽  
Syed Zawahir Hassan
Keyword(s):  
Infectious Disease ◽  
Case Report ◽  
Lymph Nodes ◽  
Cervical Lymphadenopathy ◽  
Tuberculous Lymphadenitis ◽  
Histiocytic Necrotizing Lymphadenitis ◽  
Supraclavicular Lymph Nodes ◽  
Necrotizing Lymphadenitis

Kikuchi-Fujimoto Disease (KFD), also known as histiocytic necrotizing lymphadenitis, is a rare cause of cervical lymphadenopathy. Patients usually present with localized lymphadenopathy, fever and fatigue. Because of the poorly understood etiology, it can be mistaken for an infectious disease or even malignance. Here we discuss a case of KFD that initially presented with left sided cervical lymphadenopathy that later progressed to left supraclavicular lymph nodes. Due to its characteristic overlap with other disorders like tuberculous lymphadenitis and lymphoma, KFD remains an arduous diagnosis for physicians. Therefore, one should be made aware of symptoms that can lead to misdiagnosis in patients.

scholarly journals A young woman presenting a kikuchi-fujimoto’s disease associated with induced lupus

2018 ◽  
Author(s):  
Galith Kalmi
Keyword(s):  
Lupus Erythematosus ◽  
Cervical Lymphadenopathy ◽  
Lymph Node Biopsy ◽  
Screening Tests ◽  
Unknown Etiology ◽  
Caucasian Woman ◽  
Histiocytic Necrotizing Lymphadenitis ◽  
Drug Induced ◽  
First Case ◽  
Necrotizing Lymphadenitis

Introduction: Kikuchi-Fujimoto’s disease (KFD) or histiocytic necrotizing lymphadenitis is a benign and self-limited disease of unknown etiology mainly affecting young women. Although the association with systemic lupus erythematosus (SLE) is well described, no case of drug-induced lupus erythematosus (DILE) associated KFD has not been reported so far. Case report: We herein report a 25-year old Caucasian woman, with no medical history and no medication except for oral estrogen-progestin contraception (levonorgestrel-ethinylestradiol), who presented with cervical lymphadenopathy, fever and arthralgia without weight loss, night sweats or skin involvement. An exhaustive infectious disease screening was negative and lymph node biopsy revealed histiocytic necrotizing lymphadenitis suggesting KFD. Autoimmune screening tests evidenced high titers of anti-histone antibodies suggesting DILE induced by estrogen-progestin medication. The patient received a short course of non-steroidal anti-inflammatory treatment for painful lymphadenitis and arthralgia. Oral levonorgestrel-ethinylestradiol contraceptive medication was stopped and KFD and DILE completely recovered with a long-term disappearance of anti-histone antibodies. Conclusion: We report the first case of KFD associated-DILE following oral levonorgestrel-ethinylestradiol medication. Even though levonorgestrel-ethinylestradiol induced lupus is well known, the association with KFD has never been reported and the physiopathology remained unknown. Keywords: Kikuchi-Fujimoto disease, Lupus, Levonorgestrel-ethinylestradiol

scholarly journals Case Report: Kikuchi-Fujimoto Disease: A case of supraclavicular lymphadenopathy

F1000Research ◽  
2021 ◽  
Vol 8 ◽  
pp. 1652
Author(s):  
Shiza Sarfraz ◽  
Hamza Rafique ◽  
Hassam Ali ◽  
Syed Zawahir Hassan
Keyword(s):  
Infectious Disease ◽  
Case Report ◽  
Lymph Nodes ◽  
Cervical Lymphadenopathy ◽  
Tuberculous Lymphadenitis ◽  
Histiocytic Necrotizing Lymphadenitis ◽  
Supraclavicular Lymph Nodes ◽  
Necrotizing Lymphadenitis

Kikuchi-Fujimoto Disease (KFD), also known as histiocytic necrotizing lymphadenitis, is a rare cause of cervical lymphadenopathy. Patients usually present with localized lymphadenopathy, fever and fatigue. Because of the poorly understood etiology, it can be mistaken for an infectious disease or even malignance. Here we discuss a case of KFD that initially presented with left sided cervical lymphadenopathy that later progressed to left supraclavicular lymph nodes. Due to its characteristic overlap with other disorders like tuberculous lymphadenitis and lymphoma, KFD remains an arduous diagnosis for physicians. Therefore, one should be made aware of symptoms that can lead to misdiagnosis in patients.

Histiocytic Necrotizing Lymphadenitis With Autoimmune Phenomena and Meningitis in a 14-Year-Old Girl

PEDIATRICS ◽  
1996 ◽  
Vol 98 (1) ◽  
pp. 130-133 ◽  
Author(s):  
Jason S. Debley ◽  
David J. Rozansky ◽  
Michael L. Miller ◽  
Ben Z. Katz ◽  
Marianne E. Greene
Keyword(s):  
United States ◽  
Weight Loss ◽  
Lymph Nodes ◽  
Cervical Lymphadenopathy ◽  
The United States ◽  
Histiocytic Necrotizing Lymphadenitis ◽  
Common Presentation ◽  
Necrotizing Lymphadenitis ◽  
Autoimmune Phenomena

Histiocytic necrotizing lymphadenitis, also known as Kikuchi-Fujimoto disease, is a disorder of lymph nodes originally described by Kikuchi1 and Fujimoto2 in 1972. Since 1982 this disorder has been increasingly recognized in the United States and worldwide, with the most extensive analyses of the disease presented by Dorfman et al.3-5 There has been little discussion of this entity in the pediatric literature. The most common presentation of necrotizing lymphadenitis includes fever and painless cervical lymphadenopathy. Patients may also present with weight loss, nausea, vomiting, diarrhea, chills, or diaphoresis. On occasion, myalgias, arthralgias, malar or butterfly rash, hepatomegaly, and splenomegaly have been noted.3

A Case of Subacute Necrotizing Lymphadenitis Presenting as Fever of Unknown Origin

2001 ◽  
Vol 8 (2) ◽  
pp. 253
Author(s):  
In Suk Yang ◽  
Kyung Ho Park ◽  
Jin Han Kang ◽  
So Young Kim ◽  
Won Bae Lee ◽  
...  
Keyword(s):  
Fever Of Unknown Origin ◽  
Unknown Origin ◽  
Necrotizing Lymphadenitis
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