Solitary fibrous tumor of the oral cavity: the need for an extensive sampling for a correct diagnosis

A case of solitary fibrous tumor is reported. Solitary fibrous tumor is a rare neoplasia characterized by the proliferation of fusiform cells of mesenchymal origin accounting for at least 2% of all soft tissue tumors. In this present case, the initial diagnosis was salivary gland tumor because of the location in the hard palate. Histologically, the tumor was composed by conjunctive tissue with proliferation of oval and fusiform cells. The immunohistochemical analysis was positive for CD34 and CD99. The lesion was treated by surgical resection. The clinical, imaging, histological and immunohistochemical data are discussed in this study. KeywordsSolitary fibrous tumor; Oral cavity; Hard palate; Differential diagnosis.

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Dedifferentiated Solitary Fibrous Tumor: A Concise Review

Archives of Pathology & Laboratory Medicine ◽

10.5858/arpa.2016-0570-rs ◽

2018 ◽

Vol 142 (6) ◽

pp. 761-766 ◽

Cited By ~ 11

Author(s):

Nicholas J. Olson ◽

Konstantinos Linos

Keyword(s):

Solitary Fibrous Tumor ◽

Correct Diagnosis ◽

The Body ◽

Molecular Alterations ◽

Concise Review ◽

Mesenchymal Neoplasm ◽

Fibrous Tumor ◽

Aggressive Clinical Course ◽

Age Range ◽

Ancillary Studies

Solitary fibrous tumor (SFT) is a unique mesenchymal neoplasm that was originally believed to be of submesothelial origin. Eventually, SFT expanded to include what was previously called hemangiopericytoma in other regions of the body that had similar immunohistochemical and morphologic features. Although most are benign, many studies have tried to identify histologic features that predict which tumors will behave in an aggressive manner. Recently, dedifferentiation has been described in rare cases of SFT and does appear to correlate with a more aggressive clinical course. Dedifferentiated SFT occurs in a similar age range and location as conventional SFT and can resemble multiple different malignant entities. Utilization of ancillary studies and thorough tissue sampling is important to reach the correct diagnosis. The morphologic features, immunohistochemistry, molecular alterations, and prognosis will be discussed.

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Extrapleural Solitary fibrous tumor of the oral cavity: proliferation markers, tumor suppressor gene expression, and ultrastructural features

Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology ◽

10.1016/j.tripleo.2004.06.049 ◽

2004 ◽

Vol 98 (2) ◽

pp. 206

Author(s):

C. Flaitz ◽

B. Neville ◽

J. Hicks

Keyword(s):

Gene Expression ◽

Tumor Suppressor ◽

Oral Cavity ◽

Tumor Suppressor Gene ◽

Solitary Fibrous Tumor ◽

Suppressor Gene ◽

Proliferation Markers ◽

Fibrous Tumor ◽

Extrapleural Solitary Fibrous Tumor

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Intraoral Removal of Huge Solitary Fibrous Tumor of the Oral Cavity after Embolization

Journal of Clinical Otolaryngology ◽

10.35420/jcohns.2008.19.1.114 ◽

2008 ◽

Vol 19 (1) ◽

pp. 114-118

Author(s):

Young Joo Jo ◽

Yun Su Yang ◽

Jong Seung Kim ◽

Ki Hwan Hong

Keyword(s):

Oral Cavity ◽

Solitary Fibrous Tumor ◽

Fibrous Tumor

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Large solitary fibrous tumor of the oral cavity—Report of a case

Pathology - Research and Practice ◽

10.1016/j.prp.2014.09.018 ◽

2014 ◽

Vol 210 (12) ◽

pp. 1064-1067 ◽

Cited By ~ 5

Author(s):

Denise Hélen Imaculada Pereira de Oliveira ◽

Assis Filipe Medeiros Albuquerque ◽

Matheus Dantas de Araújo Barreto ◽

Cassiano Francisco Weege Nonaka ◽

José Sandro Pereira da Silva ◽

...

Keyword(s):

Oral Cavity ◽

Solitary Fibrous Tumor ◽

Fibrous Tumor

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An Unusual Clinical Presentation of Solitary Fibrous Tumor in the Oral Cavity

Case Reports in Pathology ◽

10.1155/2017/4395049 ◽

2017 ◽

Vol 2017 ◽

pp. 1-5

Author(s):

Everton Freitas de Morais ◽

Deborah Gondim Lambert Moreira ◽

Viviane Alves De Oliveira ◽

Rodrigo Rodrigues Rodrigues ◽

Adriano Rocha Germano ◽

...

Keyword(s):

Oral Cavity ◽

Solitary Fibrous Tumor ◽

Surgical Excision ◽

Excisional Biopsy ◽

Histopathological Analysis ◽

Normal Morphology ◽

S 100 ◽

History Of ◽

Fibrous Tumor

Solitary fibrous tumor is a rare neoplasm of mesenchymal origin that usually affects the pleura. This rarity becomes more relevant in the oral cavity since the clinical features are nonspecific. A 66-year-old female patient presented with a 3-month history of a swelling in the floor of the mouth, measuring 2 cm in greatest diameter, and pain symptomatology. Occlusal and panoramic radiographs showed no bone involvement. Ultrasonography of the submandibular and parotid salivary glands revealed normal morphology, dimensions, and echogenicity. During this exam, a nodular image of low echogenicity measuring about 2.7 × 1.8 cm was detected. An excisional biopsy was performed and histopathological analysis revealed a well-defined tumor-like lesion with alternation between hypercellular areas without a defined pattern and hypocellular areas. On immunohistochemistry, the tumor was positive for CD34 and CD99 and negative forα-SMA, S-100, and bcl-2. Combining the histopathological and immunohistochemical features, the diagnosis was solitary fibrous tumor. The patient is under periodical clinical follow-up and shows no signs of recurrence 7 months after surgical excision of the tumor. The combination of clinical-pathological and immunohistochemical features is necessary for the diagnosis.

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