scholarly journals An Unusual Clinical Presentation of Solitary Fibrous Tumor in the Oral Cavity

2017 ◽  
Vol 2017 ◽  
pp. 1-5
Author(s):  
Everton Freitas de Morais ◽  
Deborah Gondim Lambert Moreira ◽  
Viviane Alves De Oliveira ◽  
Rodrigo Rodrigues Rodrigues ◽  
Adriano Rocha Germano ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Solitary Fibrous Tumor ◽  
Surgical Excision ◽  
Excisional Biopsy ◽  
Histopathological Analysis ◽  
Normal Morphology ◽  
S 100 ◽  
History Of ◽  
Fibrous Tumor

Solitary fibrous tumor is a rare neoplasm of mesenchymal origin that usually affects the pleura. This rarity becomes more relevant in the oral cavity since the clinical features are nonspecific. A 66-year-old female patient presented with a 3-month history of a swelling in the floor of the mouth, measuring 2 cm in greatest diameter, and pain symptomatology. Occlusal and panoramic radiographs showed no bone involvement. Ultrasonography of the submandibular and parotid salivary glands revealed normal morphology, dimensions, and echogenicity. During this exam, a nodular image of low echogenicity measuring about 2.7 × 1.8 cm was detected. An excisional biopsy was performed and histopathological analysis revealed a well-defined tumor-like lesion with alternation between hypercellular areas without a defined pattern and hypocellular areas. On immunohistochemistry, the tumor was positive for CD34 and CD99 and negative forα-SMA, S-100, and bcl-2. Combining the histopathological and immunohistochemical features, the diagnosis was solitary fibrous tumor. The patient is under periodical clinical follow-up and shows no signs of recurrence 7 months after surgical excision of the tumor. The combination of clinical-pathological and immunohistochemical features is necessary for the diagnosis.

scholarly journals A Rare Case of a Solitary Fibrous Tumor of the Spermatic Cord

2021 ◽  
Vol 2021 ◽  
pp. 1-3
Author(s):  
Moyosore Awobajo ◽  
Stefanie Hettwer ◽  
Sarah Hackman
Keyword(s):  
Solitary Fibrous Tumor ◽  
Spermatic Cord ◽  
Rare Case ◽  
Surgical Excision ◽  
Mesenchymal Tumors ◽  
Solitary Fibrous Tumors ◽  
Important Differential Diagnosis ◽  
History Of ◽  
Scrotal Swelling ◽  
Fibrous Tumor

Solitary fibrous tumors (SFTs) are rare mesenchymal tumors, originally identified in the pleura. Even though they have subsequently been described in several extrapleural sites, the incidence of SFTs in the spermatic cord is particularly rare. Here, we report a case of a 27-year-old male that presented with a 3-year history of left scrotal swelling. Computed tomography (CT) and ultrasound demonstrated multiple solid, hypoechoic well-circumscribed masses that were separate from the testis. Surgical excision of the mass led to pathologic diagnosis of a solitary fibrous tumor involving the spermatic cord. Solitary fibrous tumors, although rare, are an important differential diagnosis for urogenital tumors.

scholarly journals Malignant solitary fibrous tumor of the thyroid: a case-report and review of the literature

2014 ◽  
Vol 58 (4) ◽  
pp. 402-406 ◽  
Author(s):  
Wellington Alves Filho ◽  
Renata Regina da Graça Lorencetti Mahmoud ◽  
Daniel Marin Ramos ◽  
Vergilius José Furtado de Araujo-Filho ◽  
Patricia Picciarelli de Lima ◽  
...  
Keyword(s):  
Thyroid Gland ◽  
Solitary Fibrous Tumor ◽  
Spindle Cell ◽  
Spindle Cell Neoplasm ◽  
Cellular Atypia ◽  
Long Term Follow Up ◽  
History Of ◽  
Fibrous Tumor

Solitary fibrous tumor (SFT) is an uncommon spindle-cell neoplasm that most often involves the pleura, rarely occurring in extra-thoracic locations. Twenty-six cases of SFT arising in the thyroid gland have been described. We report a case of a 60-year-old woman presenting an 8-month history of enlargement of the neck associated with dysphagia. The patient underwent a right hemithyroidectomy and SFT of the thyroid was diagnosed. Immunohistochemistry showed positivity for CD34 marker, and the high number of mitoses and the presence of cellular atypia suggested that the tumor was malignant. To our knowledge, this is the second case of malignant SFT of the thyroid gland ever reported. Due to the rarity of these tumors, the indication of adjuvant therapy and prognosis are uncertain. Long-term follow-up after surgical resection seems to be advisable.

scholarly journals Omental Solitary Fibrous Tumor: A Rare Tumor at Rare Site

2021 ◽  
Author(s):  
Abhijeet Ingle ◽  
Surender Reddy ◽  
Vamshi Krishna Reddy
Keyword(s):  
Adjuvant Treatment ◽  
Solitary Fibrous Tumor ◽  
Surgical Excision ◽  
Risk Category ◽  
Rare Tumor ◽  
Rare Site ◽  
Fibrous Tumor ◽  
Extrapleural Solitary Fibrous Tumor ◽  
Risk Categorization

AbstractExtrapleural solitary fibrous tumor-hemangiopericytoma is a rare tumor. We present a case of this tumor arising in omentum, which is an extremely rare site. The diagnosis was confirmed by diffuse expression of STAT6 on immunohistochemistry. The tumor was assigned a low-risk category according to recent risk categorization models. The patient was advised close follow-up as the tumor was excised completely. These tumors have the potential for recurrence and metastasis even after surgical excision. However, there are no definitive guidelines for adjuvant treatment due to lack of data.

scholarly journals A Case of Solitary Fibrous Tumor in the External Auditory Canal

2020 ◽  
Vol 63 (11) ◽  
pp. 523-527
Author(s):  
Kyuha Shin ◽  
Juchang Kang ◽  
Kyewon Kwon ◽  
Yunsuk An
Keyword(s):  
Solitary Fibrous Tumor ◽  
External Auditory Canal ◽  
Neck Region ◽  
Surgical Excision ◽  
The Body ◽  
Head And Neck Region ◽  
Spindle Cell Neoplasm ◽  
Temporal Bone Ct ◽  
History Of ◽  
Fibrous Tumor

Solitary fibrous tumor (SFT) is a rare benign spindle-cell neoplasm, most often found in the pleura. Recently, it has been reported to appear throughout the body but rarely in head and neck region. Tumors in the external auditory canal, in particular, have been very rarely reported. We experienced a case of a 55-year-old male with a 6-month history of progressive swelling from the orifice of left external auditory canal. The tumor was round, well circumscribed, almost completely obstructing the left external auditory canal. On the enhanced temporal bone CT and enhanced paranasal sinus MRI, a 2.0×1.7 cm sized mass was observed at the left external auditory canal. He was treated with surgical excision under general anesthesia. Histopathologic examination confirmed the diagnosis of SFT. This case report presents a rare case of a SFT arising in the external auditory canal.

scholarly journals Clinicopathologic Analysis of Oral and Maxillofacial Solitary Fibrous Tumor

2020 ◽  
Vol 154 (1) ◽  
pp. 15-22
Author(s):  
Everton Freitas de Morais ◽  
Hélder Domiciano Dantas Martins ◽  
Katianne Soares Rodrigues ◽  
Glória Maria de França ◽  
Éricka Janine Dantas da Silveira ◽  
...  
Keyword(s):  
Systematic Review ◽  
Oral Cavity ◽  
Solitary Fibrous Tumor ◽  
Surgical Excision ◽  
Therapeutic Modality ◽  
Biological Behavior ◽  
Clinicopathologic Characteristics ◽  
Long Term Follow Up ◽  
Mean Size ◽  
Fibrous Tumor

Abstract Objectives The aim of this systematic review was to provide an overview of the oral and maxillofacial solitary fibrous tumor (SFT) in order to determine its clinicopathologic characteristics and biological behavior. Methods We conducted a systematic review in May 2019 in multiple databases. Cases diagnosed as SFT in the oral cavity and maxillofacial complex were included. Results Seventy-three published articles were included in our systematic review, corresponding to a total of 154 cases. SFT showed a slight female predilection (53.2%), and the cheek mucosa/cheek, tongue, and palate were the most affected anatomical sites. The mean size of SFT in the oral cavity and maxillofacial region at diagnosis was 1.4 cm. Histologic features of malignancy by morphologic analysis (P < .001) were significantly associated with a larger tumor size. Surgical excision was the most frequent therapeutic modality. Recurrence and metastasis were uncommon findings in our sample. Conclusions Histologic features of malignancy can be important parameters of tumor behavior. Adequate surgical treatment and long-term follow-up are required for these cases.

scholarly journals Solitary fibrous tumor of the scrotum: a case report and review of the literature

BMC Urology ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Tsung-Hsin Chang ◽  
Marcelo Chen ◽  
Chih-Chiao Lee
Keyword(s):  
Solitary Fibrous Tumor ◽  
Soft Tissue Tumor ◽  
English Literature ◽  
Surgical Excision ◽  
Case Presentation ◽  
Long Term Follow Up ◽  
English Medical Literature ◽  
Fibrous Tumor

Abstract Background Solitary fibrous tumor (SFT) is a rare soft tissue tumor originally reported in the pleura. Although it has been reported in various extra-pleural sites, the occurrence of SFT in the scrotum is extremely rare. Herein, we present a 48-year-old man who had scrotal SFT. There are very few reported cases of genitourinary SFTs, this is only the fifth report of SFT of the scrotum in the English medical literature. Case presentation In this study, we report on a 48-year-old man who presented with a 5 × 8 cm scrotal mass between his testes. Physical examination revealed a 4.7 × 8.5 cm lobulated tumor mass located between his testicles. Surgical excision of the tumor with scrotal approach was done and pathology reported a SFT. The patient was alive without tumor recurrence or distant metastasis during ongoing follow-up for 9 months post-operatively.. Conclusion Scrotal SFTs are very rare and only five cases have been reported in English literature to date. Treatment often involves surgical resection, and a definite diagnosis is made with the help of immunohistochemistry. The current general consensus for the management of SFTs is long-term follow-up after surgical excision of the tumor.

scholarly journals A rare mediastinal tumor-fat-forming solitary fibrous tumor

2018 ◽  
Vol 5 (4) ◽  
pp. 1069
Author(s):  
Deependra Kr. Rai ◽  
Somesh Thakur ◽  
Abhisheka Kr. ◽  
Sanjay Pandey
Keyword(s):  
Solitary Fibrous Tumor ◽  
Mediastinal Tumor ◽  
Spindle Cell ◽  
Surgical Excision ◽  
Intermediate Type ◽  
Radiological Features ◽  
Pleural Surface ◽  
Male Patients ◽  
Fibrous Tumor

Solitary fibrous tumor is uncommon spindle cell mediastinal tumor arising mainly from pleural surface. Authors discuss a clinic-radiological features of Fat forming SFT which is rare variant of SFT in 70yrs old male patients. Initially we kept differential of Liposarcoma, Lymphoma on clinico-radiologically features but later after histopathology and Immunohistochemistery turns out to be Solitary fibrous tumor. Here accurate classification is important as SFT classified as intermediate type (rarely malignant), require wide surgical excision with close follow-up.

scholarly journals Upgrade Rate of Flat Epithelial Atypia Diagnosed at Stereotactic Core Needle Biopsy of Microcalcifications: Is Excisional Biopsy Indicated?

2020 ◽  
Vol 2 (4) ◽  
pp. 336-342
Author(s):  
Paula B Gordon ◽  
Emma Branch
Keyword(s):  
Family History ◽  
High Risk ◽  
Surgical Excision ◽  
Excisional Biopsy ◽  
Flat Epithelial Atypia ◽  
High Risk Lesion ◽  
History Of ◽  
Epithelial Atypia

Abstract Objective Whether the optimal management of pure flat epithelial atypia (FEA) found on core needle biopsy (CNB) specimens is surgical excision or imaging follow-up remains controversial. This study aimed to determine the upgrade rate to ductal carcinoma in situ (DCIS), invasive carcinoma or a high-risk lesion (atypical ductal hyperplasia, atypical lobular hyperplasia, or lobular carcinoma in situ), and it explored the relationship between a family history of breast cancer and the risk of upgrade. Methods Cases with pure FEA found on stereotactic CNB of microcalcifications between March 2011 to December 2017 were followed by excisional biopsy or periodic imaging. The proportion of cases upgraded to a high-risk lesion and the odds of upgrade as related to a family history of breast cancer were determined with 95% confidence intervals (CIs). Results We identified 622 cases of pure FEA; 101 (16.2%) underwent surgical excision and 269 (43.2%) had imaging follow-up of ≥ 24 months. There were no upgrades to DCIS or invasive cancer in any of these 370 individuals (0%), and 4.6% (17/370; 95% CI: 2.9%–7.2%) were upgraded to a high-risk lesion. There was a nonstatistically significant trend between family history and upgrade to high-risk lesion (odds ratio 1.72 [95% CI: 0.65%–4.57%]). Conclusion In our study, the upgrade rate of pure FEA to malignancy was 0%. We suggest that regular imaging follow-up is an appropriate alternative to surgery. Because of potential differences in biopsy techniques and pathologist interpretation of the primary biopsy, individual institutions should audit their own results prior to altering their management of FEA.

Pazopanib-associated secondary adrenal insufficiency in a patient with malignant solitary fibrous tumor

2021 ◽  
pp. 107815522110160
Author(s):  
Muhammed Muhiddin Er ◽  
Murat Araz ◽  
Meryem Karabacak ◽  
Muzaffer Uğraklı ◽  
Melek Karakurt Eryılmaz ◽  
...  
Keyword(s):  
Adrenal Insufficiency ◽  
Solitary Fibrous Tumor ◽  
Single Case ◽  
Soft Tissue Sarcomas ◽  
Pituitary Hormones ◽  
Secondary Adrenal Insufficiency ◽  
Primary Adrenal Insufficiency ◽  
Hypoglycemic Attack ◽  
Fibrous Tumor

Introduction Pazopanib is an agent that is being successfully used in soft tissue sarcomas. Some endocrine side effects may develop during pazopanib treatment. Here, we presented a case diagnosed with secondary adrenal insufficiency while being investigated for etiology of hypoglycemia which developed after pazopanib. Case report A 69-year-old male patient was operated in June 2019 due to a lung mass 26 × 18 × 10 cm in size. Pathological diagnosis revealed a solitary fibrous tumor with malignant behavior. The patient received three lines of chemotherapy. After pazopanib treatment, a hypoglycemic attack was reported. Management and outcome: Blood cortisol and ACTH (Adrenocorticotropic hormone) levels were not increased at the time of the hypoglycemic attack, and levels of other pituitary hormones were found to be normal. Electrolyte levels were in normal range. Since the counteracting hormone did not reach a sufficient level, it was considered secondary adrenal insufficiency. Hypoglycemic attacks did not occur during follow-up while taking steroid therapy and pazopanib. Discussion A single case of primary adrenal insufficiency has been reported in the literature. We here present a case who developed hypoglycemia after pazopanib and was diagnosed with drug-associated secondary adrenal insufficiency. When hypoglycemia develops during pazopanib treatment, we must be aware of adrenal insufficiency.

Extramedullary Plasmacytoma of The Frontal Sinus: A Case Report

FACE ◽  
2021 ◽  
pp. 273250162110536
Author(s):  
Joshua Harrison ◽  
Samantha Marley ◽  
Shawhin Shahriari ◽  
Christian Bowers ◽  
Anil Shetty
Keyword(s):  
Frontal Sinus ◽  
Surgical Excision ◽  
Extramedullary Plasmacytoma ◽  
High Rate ◽  
Solitary Plasmacytoma ◽  
Case Presentation ◽  
Long Term Follow Up ◽  
History Of

We report a rare case of an extramedullary plasmacytoma (EMP) in the frontal sinus with an indolent clinical presentation. Although a history of trauma was absent, the initial diagnosis was a mucocele, based on the radiological findings. Upon surgical excision, the patient was found to have an EMP. EMP, a form of solitary plasmacytoma, has a significantly high rate of conversion to multiple myeloma. This mandates long-term follow-up, even after successful radiotherapy and/or resection. While radiation therapy is generally considered a first line treatment for EMP, surgical intervention may provide optimal treatment in complicated cases. This case presentation highlights the prognosis of patients diagnosed with EMP.

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