Cathepsins B, H and L activities in gingival crevicular fluid from chronic adult periodontitis patients and experimental gingivitis subjects

1990 ◽  
Vol 25 (2) ◽  
pp. 69-73 ◽  
Author(s):  
Kazushi Kunimatsu ◽  
Kenji Yamamoto ◽  
Eiji Ichimaru ◽  
Yuzo Kato ◽  
Ihachi Kato
Keyword(s):  
Gingival Crevicular Fluid ◽  
Experimental Gingivitis ◽  
Crevicular Fluid

scholarly journals Resistance and resilience to experimental gingivitis: a systematic scoping review

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Charifa Zemouri ◽  
Nicholas S. Jakubovics ◽  
Wim Crielaard ◽  
Egija Zaura ◽  
Michael Dodds ◽  
...  
Keyword(s):  
Scoping Review ◽  
Gingival Crevicular Fluid ◽  
Oral Microbiome ◽  
Induction Phase ◽  
Experimental Gingivitis ◽  
Normal Composition ◽  
Baseline Values ◽  
Cystatin Sn ◽  
Crevicular Fluid ◽  
Reporting Data

Abstract Background This systematic scoping review aimed to identify changes in biomarkers of microbiological, immunological and biochemical origin during experimental gingivitis (EG) studies that might indicate resistance and resilience. Methods The term ‘experimental gingivitis’ was run in PubMed from inception to April 11th, 2018. From the 411 studies retrieved, 22 studies were included for this review. Results Studies reporting data on biomarker changes during and after full mouth EG trial were included. Two studies reported findings on changes in biomarkers of microbiological, 12 on immunological and eight on biochemical origin. Changes were reported in the induction phase, and occasionally in the resolution phase. The microbiological composition of both supragingival and subgingival dental plaque changed over the course of EG to a more pathogenic direction, but showed a shift back to a more normal composition. This indicates resilience of the oral microbiome. For immunological biomarkers, it was challenging to retrieve a robust pattern of changes across multiple studies. IL-1β and IL-6 in saliva and in gingival crevicular fluid increased during induction phase and returned in the resolution phase below baseline values. The biochemical parameters cystatin-SN, cystatin-S and lactoferrin in saliva were increased at the end of induction phase, however also here no clear pattern emerged based on all available studies. Conclusions More research is needed to investigate which microbiological, immunological, and biochemical biomarkers can be useful for future investigations into the resistance and resilience of the oral cavity to experimental gingivitis.

Bioassay of interleukin 1 (IL-1) in human gingival crevicular fluid during experimental gingivitis

1992 ◽  
Vol 37 (2) ◽  
pp. 153-156 ◽  
Author(s):  
D.F. Kinane ◽  
F.P. Winstanley ◽  
E. Adonogianaki ◽  
N.A. Moughal
Keyword(s):  
Gingival Crevicular Fluid ◽  
Interleukin 1 ◽  
Experimental Gingivitis ◽  
Crevicular Fluid

Granulocyte medullasin levels in gingival crevicular fluid from chronic adult periodontitis patients and experimental gingivitis subjects

1990 ◽  
Vol 25 (6) ◽  
pp. 352-357 ◽  
Author(s):  
Kazushi Kunimatsu ◽  
Eiji Ichimaru ◽  
lhachi Kato ◽  
Yuzo Kato ◽  
Yasutaka Sonoda ◽  
...  
Keyword(s):  
Gingival Crevicular Fluid ◽  
Experimental Gingivitis ◽  
Crevicular Fluid

Effect of Age on Gingival Crevicular Fluid Concentrations of MIF and PGE2

2009 ◽  
Vol 88 (7) ◽  
pp. 639-643 ◽  
Author(s):  
C. Nonnenmacher ◽  
K. Helms ◽  
M. Bacher ◽  
R.M. Nüsing ◽  
C. Susin ◽  
...  
Keyword(s):  
Gingival Crevicular Fluid ◽  
Age Groups ◽  
Prostaglandin E ◽  
Older Individuals ◽  
Experimental Gingivitis ◽  
Parvimonas Micra ◽  
Bacterial Accumulation ◽  
High Concentrations ◽  
Crevicular Fluid ◽  
Effect Of Age

We used an experimental gingivitis study design to compare crevicular fluid concentrations of Migration Inhibitory Factor (MIF) and Prostaglandin E2 (PGE2) in younger (18 to 30 yrs) and older (46 to 77 yrs) healthy adults. PGE2 increased after 1 wk in younger participants, whereas it decreased in older individuals after 1 wk of plaque accumulation. A significant interaction between age and time was observed for PGE2 (p = 0.04). High concentrations of MIF were identified in both age groups at baseline. MIF increased in the younger participants, whereas in the older individuals a decrease over time was observed. MIF concentration was positively correlated with plaque index and gingival index in the older age group. Total counts of bacteria, Parvimonas micra and Prevotella intermedia, were significantly correlated with MIF concentration in older participants. In conclusion, MIF and PGE2 production in response to bacterial accumulation seems to be modified by age.

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