Association between genetic variants of the metabotropic glutamate receptor 3 (GRM3) and cognitive set shifting in healthy individuals

2010 ◽  
Author(s):  
B. T. Baune ◽  
T. Suslow ◽  
C. Beśte ◽  
E. Birosova ◽  
K. Domschke ◽  
...  
Keyword(s):  
Glutamate Receptor ◽  
Genetic Variants ◽  
Metabotropic Glutamate Receptor ◽  
Cognitive Set ◽  
Set Shifting ◽  
Healthy Individuals ◽  
Metabotropic Glutamate ◽  
Metabotropic Glutamate Receptor 3

scholarly journals Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAM

2012 ◽  
Vol 22 (12) ◽  
pp. 3921-3925 ◽  
Author(s):  
Douglas J. Sheffler ◽  
Cody J. Wenthur ◽  
Joshua A. Bruner ◽  
Sheridan J.S. Carrington ◽  
Paige N. Vinson ◽  
...  
Keyword(s):  
Glutamate Receptor ◽  
Metabotropic Glutamate Receptor ◽  
Metabotropic Glutamate ◽  
Metabotropic Glutamate Receptor 3

DNA sequence variants in the metabotropic glutamate receptor 3 and risk to schizophrenia: an association study

2008 ◽  
Vol 18 (1) ◽  
pp. 25-30 ◽  
Author(s):  
Sibylle G. Schwab ◽  
Christie Plummer ◽  
Margot Albus ◽  
Margitta Borrmann-Hassenbach ◽  
Bernard Lerer ◽  
...  
Keyword(s):  
Association Study ◽  
Dna Sequence ◽  
Glutamate Receptor ◽  
Metabotropic Glutamate Receptor ◽  
Sequence Variants ◽  
Metabotropic Glutamate ◽  
Metabotropic Glutamate Receptor 3 ◽  
Dna Sequence Variants

scholarly journals Metabotropic glutamate receptor 3 activation is required for long-term depression in medial prefrontal cortex and fear extinction

2015 ◽  
Vol 112 (4) ◽  
pp. 1196-1201 ◽  
Author(s):  
Adam G. Walker ◽  
Cody J. Wenthur ◽  
Zixiu Xiang ◽  
Jerri M. Rook ◽  
Kyle A. Emmitte ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Glutamate Receptor ◽  
Metabotropic Glutamate Receptor ◽  
Fear Extinction ◽  
Long Term Depression ◽  
Metabotropic Glutamate ◽  
Metabotropic Glutamate Receptor 3

Clinical studies have revealed that genetic variations in metabotropic glutamate receptor 3 (mGlu3) affect performance on cognitive tasks dependent upon the prefrontal cortex (PFC) and may be linked to psychiatric conditions such as schizophrenia, bipolar disorder, and addiction. We have performed a series of studies aimed at understanding how mGlu3 influences PFC function and cognitive behaviors. In the present study, we found that activation of mGlu3 can induce long-term depression in the mouse medial PFC (mPFC) in vitro. Furthermore, in vivo administration of a selective mGlu3 negative allosteric modulator impaired learning in the mPFC-dependent fear extinction task. The results of these studies implicate mGlu3 as a major regulator of PFC function and cognition. Additionally, potentiators of mGlu3 may be useful in alleviating prefrontal impairments associated with several CNS disorders.

Sign in / Sign up

Export Citation Format

Share Document