Coeliac Disease. V Some Experiments on the Cause of the Harmful Effect of Wheat Gliadin (Preliminary communication)

1955 ◽  
Vol 44 (5) ◽  
pp. 465-469 ◽  
Author(s):  
J. H. VAN DE KAMER ◽  
H. A. WEIJERS
The Lancet ◽  
1973 ◽  
Vol 301 (7816) ◽  
pp. 1363-1364 ◽  
Author(s):  
R.R.W. Townley ◽  
H.J. Cornell ◽  
P.S. Bhathal ◽  
J.D. Mitchell

BMJ ◽  
1984 ◽  
Vol 289 (6437) ◽  
pp. 83-83 ◽  
Author(s):  
P J Ciclitira ◽  
H J Ellis ◽  
N L Fagg

PEDIATRICS ◽  
1956 ◽  
Vol 17 (5) ◽  
pp. 699-699

Skin tests have not proven reliable as a means of determining gastrointestinal sensitivity to wheat. In view of the implication of wheat gliadin in the pathogenesis of celiac disease it becomes desirable to have a convenient, objective criterion of gastrointestinal sensitivity to gliadin. The authors propose a gliadin tolerance test. The patient is given a test dosage of gliadin and the level of glutamine is determined in the blood afterwards at 1, 2, 3, 4, and 5-hour intervals. Normal patients do not show an increase of the glutamine in the blood of more than 50 per cent while children with coeliac disease who do not tolerate gliadin show increases greater than 50 per cent and up to fourfold increases.


1986 ◽  
Vol 79 (4) ◽  
pp. 204-205 ◽  
Author(s):  
J F Mayberry ◽  
H L Smart ◽  
P J Toghill

One hundred and twenty patients who were members of the Nottinghamshire Coeliac Group completed a questionnaire about the occurrence of coeliac disease, ulcerative colitis and Crohn's disease amongst first-degree relatives. Siblings were at a 20-fold risk of developing coeliac disease and a 15-fold risk of developing ulcerative colitis, and significantly increased risks for these two conditions were also seen in other family members. The relatives of patients with coeliac disease are at increased risk not only of developing coeliac disease but also ulcerative colitis. This provides further support for a possible role of a dietary allergen in the development of ulcerative colitis.


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