Heart risk associated with weight loss in anorexia nervosa and eating disorders: risk factors for QTc interval prolongation and dispersion

AbstractThis paper aimed to collect and unite facts known about the effect of methadone treatment on QTc interval prolongation that could determine precipitating factors in the development of heart arrhythmias and their consequences (Torsade de Pointes and sudden cardiac death), and to raise the methadone treatment safety level.Studies conducted up to now clearly demonstrate that methadone therapy evokes changes in the heart’s electrical conduction, but those studies also show that QTc interval prolongation could be precipitated by other factors. The most often present risk factors in our research were dose of methadone, co-medication, and co-morbidity, but other relevant risk factors were gender, age, misuse of illicit drugs, therapy length and tobacco use.Active participation in modern treatment processes and implementation of knowledge acquired recently into daily practice, such as setting up reutilized questionnaires and diagnostic methods to expose higher risk for complications and providing broader therapeutic range for cases of drug replacement necessity, will enhance therapy safety level and bring us to the next step of resocialization of these patients, which needs to remain the final goal of treatment.

Download Full-text

Is QTc-Interval Prolongation an Inherent Feature of Eating Disorders? A Cohort Study

The American Journal of Medicine ◽

10.1016/j.amjmed.2020.02.015 ◽

2020 ◽

Vol 133 (9) ◽

pp. 1088-1094.e1 ◽

Cited By ~ 4

Author(s):

Mori J. Krantz ◽

Dan V. Blalock ◽

Kundai Tanganyika ◽

Morteza Farasat ◽

Jennifer McBride ◽

...

Keyword(s):

Eating Disorders ◽

Cohort Study ◽

Qtc Interval ◽

Interval Prolongation ◽

Inherent Feature ◽

Qtc Interval Prolongation

Download Full-text

QTc interval prolongation in critically ill patients: Prevalence, risk factors and associated medications

PLoS ONE ◽

10.1371/journal.pone.0199028 ◽

2018 ◽

Vol 13 (6) ◽

pp. e0199028 ◽

Cited By ~ 14

Author(s):

Flávia Medeiros Fernandes ◽

Eliane Pereira Silva ◽

Rand Randall Martins ◽

Antonio Gouveia Oliveira

Keyword(s):

Risk Factors ◽

Critically Ill ◽

Critically Ill Patients ◽

Qtc Interval ◽

Interval Prolongation ◽

Qtc Interval Prolongation

Download Full-text

Prevalence, Risk Factors and In-hospital Outcomes of QTc Interval Prolongation in Liver Cirrhosis

The American Journal of the Medical Sciences ◽

10.1016/j.amjms.2016.06.012 ◽

2016 ◽

Vol 352 (3) ◽

pp. 285-295 ◽

Cited By ~ 10

Author(s):

Jiancheng Zhao ◽

Xingshun Qi ◽

Feifei Hou ◽

Zheng Ning ◽

Xintong Zhang ◽

...

Keyword(s):

Risk Factors ◽

Liver Cirrhosis ◽

Qtc Interval ◽

Interval Prolongation ◽

Hospital Outcomes ◽

Qtc Interval Prolongation

Download Full-text

Evaluation of QTc Interval Effects of Antipsychotic Medications for Intensive Care Unit Delirium in Pediatric Patients

The Journal of Pediatric Pharmacology and Therapeutics ◽

10.5863/1551-6776-26.1.87 ◽

2021 ◽

Vol 26 (1) ◽

pp. 87-91

Author(s):

Lisa M. Hutchins ◽

Andrakeia Shipman ◽

Kanecia O. Zimmerman ◽

Travis S. Heath

Keyword(s):

Risk Factors ◽

Intensive Care Unit ◽

Intensive Care ◽

Pediatric Patients ◽

Qtc Interval ◽

Interval Prolongation ◽

Antipsychotic Medications ◽

Qtc Interval Prolongation ◽

Intensive Care Unit Delirium ◽

Icu Delirium

OBJECTIVE Intensive care unit delirium is an increasingly recognized problem in pediatric patients. Controversy exists regarding the safety and efficacy of antipsychotic medications for this indication. The objective of this study was to determine the incidence of and risk factors for QTc interval prolongation in pediatric patients treated with antipsychotics for ICU delirium. METHODS Retrospective chart review of pediatric patients admitted to the pediatric ICU or pediatric cardiac ICU and diagnosed with ICU delirium between October 1, 2014, and October 31, 2015. Patients were included if they received at least 1 dose of an antipsychotic for the treatment of delirium after a positive screen using the Cornell Assessment of Pediatric Delirium scoring tool. RESULTS For the 26 patients included, the median change in QTc interval on treatment was −4 msecs. Two patients (8%) had QTc interval prolongation while on antipsychotic therapy. No risk factors were identified in these 2 patients that put them at increased risk for QTc interval prolongation. CONCLUSIONS The incidence of QTc interval prolongation in pediatric patients who were treated with antipsychotics for ICU delirium was low. There is need for future research to determine which pediatric patients are at risk for QTc interval prolongation when antipsychotic medications are used for the treatment of ICU delirium.

Download Full-text