An open, non-comparative, multicentre study on the impact of alfuzosin on sexual function using the Male Sexual Health Questionnaire in patients with benign prostate hyperplasia

Abstract Benign prostate hyperplasia is a dysfunctional disease with an elevated prevalence. Despite the accepted impact of aging and testosterone (TES) in its pathophysiology, its aetiology remains unknown. Recent studies described that serotonin (5-HT) inhibits benign prostate growth through the modulation of the androgen receptor, in the presence of TES. Accordingly, this work aimed to determine the impact of castration and TES replacement in plasmatic and prostatic 5-HT regulation. C57BL/6 mice were submitted to surgical castration and divided into three groups, continually exposed to either vehicle or different TES doses for 14 days. Plasmatic 5-HT concentration was measured before and after castration, and after TES reintroduction. Finally, total prostatic weight and intra-prostatic 5-HT were determined in the different groups. Our results demonstrate that mice prostate exhibits high 5-HT tissue levels and that intra-prostatic total 5-HT was independent of castration or TES reintroduction, in all studied groups. Also, 5-HT plasmatic concentration significantly increased after castration and then normalized after TES administration. Our findings revealed that mice prostate has a high 5-HT content and that total prostatic 5-HT levels do not depend on androgens’ action. On the other hand, castration induced a significant increase in plasmatic 5-HT concentration, raising the hypothesis that androgens might be regulating the production of extra-prostatic 5-HT.

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The impact of tamsulosin on cognition in Alzheimer disease with benign prostate hyperplasia

Medicine ◽

10.1097/md.0000000000020240 ◽

2020 ◽

Vol 99 (22) ◽

pp. e20240

Author(s):

Jong-Hee Sohn ◽

Sang-Hwa Lee ◽

Young-Suk Kwon ◽

Jong-Ho Kim ◽

Youngmi Kim ◽

...

Keyword(s):

Alzheimer Disease ◽

Benign Prostate Hyperplasia ◽

Prostate Hyperplasia ◽

The Impact ◽

Benign Prostate

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A Pilot Study on the Comparative Patient Satisfaction with Tamsulosin and Silodosin Therapy in Benign Prostate Hyperplasia and to Evaluate the Impact of Patient Counselling

Journal of Medical Science And clinical Research ◽

10.18535/jmscr/v7i4.161 ◽

2019 ◽

Vol 7 (4) ◽

Author(s):

Ashlin Treesa Johnson ◽

Keyword(s):

Patient Satisfaction ◽

Pilot Study ◽

Benign Prostate Hyperplasia ◽

Patient Counselling ◽

Prostate Hyperplasia ◽

The Impact ◽

Benign Prostate

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HUBUNGAN USIA, OBESITAS DAN RIWAYAT PENYAKIT DIABETES MELLITUS DENGAN KEJADIAN BENIGN PROSTATE HYPERPLASIA (BPH) DERAJAT IV DI RSUD DR. M. HAULUSSY AMBON PERIODE 2012-2014

MOLUCCA MEDICA ◽

10.30598/molmed.2017.10.2.141 ◽

2017 ◽

pp. 141-151

Author(s):

Andrew Ruspanah

Keyword(s):

Diabetes Mellitus ◽

Benign Prostate Hyperplasia ◽

Chi Square ◽

Cross Sectional ◽

Prostate Hyperplasia ◽

Benign Prostate

Pendahuluan. Benign Postate Hiperplasia (BPH) adalah penyakit yang umumnya terjadi pada pria lansia yang disebabkan oleh penuaan. Hiperplasia prostat adalah pertumbuhan jaringan nodul fibroadenomatosa pada prostat. Pembesaran prostat jinak merupakan penyakit yang tersering kedua setelah batu saluran kemih didapatkan secara klinis di Indonesia. Tujuan. Penelitian ini bertujuan untuk mengetahui hubungan antara usia, obesitas dan riwayat diabetes mellitus dengan kejadian Benign Prostate Hyperplasia (BPH) grade IV di Rumah Sakit Dr. M. Haulussy Ambon periode 2012-2014. Metode. Jenis penelitian ini adalah penelitian analitik desain Cross-Sectional, dengan menggunakan catatan medis data di ruang operasi di Rumah Sakit Dr. M. Haulussy Ambon Tahun 2012-2014 dan memperoleh jumlah sampel yang memenuhi kriteria inklusi sebanyak 239, yang diambil dengan teknik total sampling. Analisis dilakukan dengan analisis univariat dan bivariat menggunakan uji Chi Square. Hasil yang di temukan dalam penelitian ini bahwa kejadian BPH lebih besar pada mereka yang berusia> 65 tahun dan 56-65 tahun dibandingkan dengan usia 46-55 dan <46 tahun dengan hasil tes menunjukkan adanya hubungan antara usia dengan BPH dengan nilai (p= 0,000), ada hubungan antara obesitas dengan nilai BPH (p=0,019) dan riwayat diabetes mellitus setelah menggunakan uji Chi-Square, hubungan antara riwayat diabetes mellitus dengan BPH dengan nilai (p = 0,000). Kesimpulan. Ada hubungan antara umur, obesitas dan riwayat diabetes mellitus dengan kejadian BPH.

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